Herbal Products in Postsurgical Wound Healing – Incision, Excision and Dead Space Wound Models

Herman, Anna; Herman, Andrzej Przemysław

doi:10.1055/a-1162-9988

Cited by 10 publications

(9 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the included studies reported on and discussed the potential ability of M. oleifera in accumulating collagen, the most important protein for wound recovery [ 9 , 34 , 46 ]. Collagen formation is an important step in wound healing, as synthesized collagen will enhance epithelialization, a key factor in excision wound recovery.…”

Section: Discussionmentioning

confidence: 99%

“…In order to reduce the wound burden towards healthcare and the economy, new therapeutic approaches and technologies are continually being developed [ 8 ]. At the same time, studies to evaluate the efficacy of documented traditional approaches for wound healing, such as herbs [ 9 , 10 , 11 , 12 , 13 ], or other alternative methods, such as leech therapy [ 14 , 15 ], are also conducted. An ideal wound dressing should be non-toxic and cost effective.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Scoping Review: Evaluation of Moringa oleifera (Lam.) for Potential Wound Healing in In Vivo Studies

et al. 2022

View full text Add to dashboard Cite

Wound healing is a natural process to restore damaged tissues due to loss of tissue integrity. Moringa oleifera (locally known as merunggai in Malaysia) has been traditionally used in various ailments, including for wound management. To evaluate the wound healing properties in M. oleifera, publications were searched and selected following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement with predetermined inclusion criteria. The databases searched for primary studies include PubMed, Google Scholar, Science Direct, LILACS, ClinicalTrials.gov, and CENTRAL. In total, 18 in vivo studies were included, which involved the leaves, while the remaining 5 studies involved other plant parts tested on excision, incision, dead space, abrasion, and burn-induced wound models. All studies reported significant wound healing abilities. Most studies used different topical formulations of aqueous leaves extract. The accumulation of collagen content and underlying wound healing mechanism through antimicrobial, antioxidant, and anti-inflammatory activities may be contributed by its bioactive phytochemical content, which has the potential to accelerate the wound contraction, increase the rate of epithelialization, and protect tissues against oxidative damage. In conclusion, M. oleifera showed wound healing potential but further studies are warranted to determine the main bioactive phytocompounds and safety.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Scoping Review: Evaluation of Moringa oleifera (Lam.) for Potential Wound Healing in In Vivo Studies

et al. 2022

View full text Add to dashboard Cite

show abstract

“…It is then on a suitable model of the wound healing process that ADHE properties have been tested in this study. Evaluation of the wounds surfaces and the rate of contraction of these wounds, a parameter that characterizes the closure of the wound (Darré et al, 2014), indicated that ADHE incorporated in Carbopol gel and administrated topically accelerated the wound Considering that the cicatrization of an injured skin is a complex process involving multiple mechanisms such as collagen production, inflammatory cells signaling and free radicals management (Herman and Herman, 2020), we investigated in vivo the hydroxyproline production and in vitro the anti-inflammatory and antioxidant activities of ADHE. The measurement of hydroxyproline is frequently used as a reliable index to quantify collagen in tissues.…”

Section: Discussionmentioning

confidence: 99%

Hydroalcoholic extract of Adansonia digitatas trunk bark, in topical application, possess in vivo wound healing and in vitro anti-inflammatory and antioxidant activities

Abdou-Rachidou¹,

Yendubé²,

Komi³

et al. 2022

J. Pharmacognosy Phytother.

View full text Add to dashboard Cite

Adansonia digitata is a tree plant used in west African local pharmacopoeia. This work aimed to evaluate the wound healing properties of its trunk bark's hydroethanolic extract in wistar rats. The model of excision wound was used. Wistar rats were treated post-excision topically with neutral carbopol gel (Control), carbopol gels containing 2.5 and 5% of A. digitata hydroethanolic trunk bark extract (ADHE) and L-Mesitran. Pictures were taken post excision for analysis. Biopsies were realized for histological examination of the skin excised and for hydroxyproline determination. In vitro membrane stabilization anti-inflammatory test, DPPH and FRAP antioxidant tests, and phytochemical tests were performed. The results show a better rate of contraction in ADHE 2.5 and 5% animals (+56 ± 0.52% and +68 ± 0.24% respectively) as earlier as on day three post-excision. The hydroxyproline assay confirmed a better collagen production in ADHE 2.5% and 5% animals (+102.5 ± 2.9%, and +107 ± 3.0% respectively). Histological analysis showed a rapid re-epithelialization in ADHE animals. The antiinflammatory test indicated an IC50 of 16.521 ± 0.525 µg/mL, very close to Aspirin (16.826 ± 0.341 µg/mL), showing a possible anti-inflammatory activity of ADHE. The extract reduced DPPH radical (IC50 of 344.985 ± 17.139 µg/mL) and ferric ions (EC50 = 178.689 ± 0.250 µg/mL). Phytochemical investigations revealed the presence of alkaloids, terpenoids, and polyphenolic compounds. Flavonoids in particular, with an amount of 51.694 ± 0.174 mgER/g, should explain the wound healing activity observed, making the hydroethanolic extract of A. digitata a potential remedy for excision wounds.

show abstract

“…Wounds have happened due to the loss of histological composition of the skin tissue due to internal or external factors or sequential loss of function in any layer of the skin, which leads to tissue disturbance (Herman and Bordoni 2020). The existence of wounds permits the entrance of different microbial agents as bacteria and viruses or any foreign elements, into the body.…”

Section: Introductionmentioning

confidence: 99%

The wound healing effect of botanicals and pure natural substances used in in vivo models

El-Sherbeni

Negm

2023

Inflammopharmacol

View full text Add to dashboard Cite

Repairing the wound is a multistep process that includes the spatial and temporal synchronization of a different range of cell types to increase the speed of wound contraction, the proliferation of epithelial cells, and collagen formation. The need for proper management of acute wounds to be cured and not turned into chronic wounds is a significant clinical challenge. The traditional practice of medicinal plants in many regions of the world has been used in wound healing since ancient times. Recent scientific research introduced evidence of the efficacy of medicinal plants, their phyto-components, and the mechanisms underlying their wound-repairing activity. This review aims to briefly highlight the wound-curing effect of different plant extracts and purely natural substances in excision, incision, and burn experimental animal models with or without infection of mice, rats (diabetic and nondiabetic), and rabbits in the last 5 years. The in vivo studies represented reliable evidence of how powerful natural products are in healing wounds properly. They have good scavenging activity against Reactive oxygen species (ROS) and anti-inflammatory and antimicrobial effects that help in the process of wound healing. It is evident that incorporating bioactive natural products into wound dressings of bio- or synthetic polymers in nanofiber, hydrogel, film, scaffold, and sponge forms showed promising results in different phases of the wound-curing process of haemostasis, inflammation, growth, re-epithelialization, and remodelling.

show abstract

Herbal Products in Postsurgical Wound Healing – Incision, Excision and Dead Space Wound Models

Cited by 10 publications

References 68 publications

Scoping Review: Evaluation of Moringa oleifera (Lam.) for Potential Wound Healing in In Vivo Studies

Scoping Review: Evaluation of Moringa oleifera (Lam.) for Potential Wound Healing in In Vivo Studies

Hydroalcoholic extract of Adansonia digitatas trunk bark, in topical application, possess in vivo wound healing and in vitro anti-inflammatory and antioxidant activities

The wound healing effect of botanicals and pure natural substances used in in vivo models

Contact Info

Product

Resources

About