Scoping Review: Evaluation of Moringa oleifera (Lam.) for Potential Wound Healing in In Vivo Studies

Abstract

Wound healing is a natural process to restore damaged tissues due to loss of tissue integrity. Moringa oleifera (locally known as merunggai in Malaysia) has been traditionally used in various ailments, including for wound management. To evaluate the wound healing properties in M. oleifera, publications were searched and selected following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement with predetermined inclusion criteria. The databases searched for primary studies include PubMed, Google Scholar, Science Direct, LILACS, ClinicalTrials.gov, and CENTRAL. In total, 18 in vivo studies were included, which involved the leaves, while the remaining 5 studies involved other plant parts tested on excision, incision, dead space, abrasion, and burn-induced wound models. All studies reported significant wound healing abilities. Most studies used different topical formulations of aqueous leaves extract. The accumulation of collagen content and underlying wound healing mechanism through antimicrobial, antioxidant, and anti-inflammatory activities may be contributed by its bioactive phytochemical content, which has the potential to accelerate the wound contraction, increase the rate of epithelialization, and protect tissues against oxidative damage. In conclusion, M. oleifera showed wound healing potential but further studies are warranted to determine the main bioactive phytocompounds and safety.

Moringa - The Miracle Tree: An Overview of its Nutritional and Medicinal Properties

“…Moringa contains bioactive compounds that promote wound healing, including antiinflammatory and antimicrobial properties. It may help accelerate the healing process, reduce inflammation, and prevent infection [55]. Additionally, Moringa oil is rich in nutrients and antioxidants, making it a potential ingredient for skincare products to nourish and protect the skin [56].…”

Ekstrak Moringa Oleifera Mempercepat Proses Penyembuhan Luka: Systematic Review

“…Oleh karena itu, proliferasi fibroblas dan kolagen produksi adalah cara untuk mempelajari aktivitas obat pada penyembuhan. (Mohammad Shafie et al, 2022) Luka menyebabkan peradangan yang menyebabkan produksi radikal bebas oleh sel fagosit.Peningkatan produksi radikal bebas ini menunda proses penyembuhan luka; dengan demikian, dibutuhkan strategi yang dapat menghambat produksi radikal bebas ini agar terapi dapat bermanfaat dalam tindakan penyembuhan luka. Shoedoeva dkk, telah melaporkan banyak tanaman yang mempercepat penyembuhan luka yang dibantu dengan oleh mekanisme pengikatan radikal bebas.…”

Innovative Materials with Possible Applications in the Wound Dressings Field: Alginate-Based Films with Moringa oleifera Extract

“…Further determinations include in vivo application and cytotoxicity evaluation, wound models, and safety assessments. According to other results presented in the literature, this plant is one of the best options regarding natural materials with regenerative properties, being the most used compound for wound healing compared to the topical usage of other extracts [42].…”