Herbal Reference Standards

Schwarz, Michael; Klier, B; Sievers, Hartwig

doi:10.1055/s-0029-1185705

Cited by 11 publications

(3 citation statements)

References 5 publications

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“…These standards are expensive and purchased from specially certified drug laboratories, United States Pharmacopeia companies, European Pharmacopoeia, Japanese Pharmacopoeia, Swiss Pharmacopoeia, French Pharmacopoeia, Mexican Pharmacopoeia, National Institute for Standards and Testing (NIST), etc. [3,4]. Working standards can be used instead of the official reference pharmacopoeia standards for routine analyses and are an integral part of any pharmaceutical laboratory [5].…”

Section: Introductionmentioning

confidence: 99%

Effective Isolation of Picrocrocin and Crocins from Saffron: From HPTLC to Working Standard Obtaining

et al. 2022

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Saffron is widely cultivated and used as a spice. Recently published data on the chemical composition and pharmacological potential of saffron determine its use in pharmacy and medicine. The proposed high-performance thin-layer chromatography (HPTLC) method allows good separation of 11 analytes. The saffron quality (Iran, Ukraine, Spain, Morocco samples) assessment was based on the European Pharmacopoeia monograph and ISO 3632. The HPTLC method for the safranal, crocin, and picrocrocin quantification was proposed and validated. The crocins content in Ukrainian saffron was from 17.80% to 33.25%. Based on qualitative and quantitative assessment results, the saffron sample from Zaporizhzhia (Ukraine) had the highest compounds content and was chosen to obtain the working standards of picrocrocin and crocins (trans-4GG, trans-2G, trans-3Gg) by preparative chromatography. The compounds were isolated from lyophilized extract of saffron using a Symmetry Prep C18 column (300 × 19 mm × 7 µm), and identified by spectroscopic techniques (HPLC-DAD, UPLC-ESI-MS/MS). The purity of crocins and picrocrocin was more than 97%. A novel method proposed to obtain working standards is simple and reproducible for the routine analysis of saffron quality control.

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Section: Introductionmentioning

confidence: 99%

Effective Isolation of Picrocrocin and Crocins from Saffron: From HPTLC to Working Standard Obtaining

et al. 2022

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“…This situation is obviously completely different than those that inolve pure chemical pharmaceuticals. In other words, it makes no sense to treat the herbal drug exactly the same as a chemical medicine [16]. This brings us to a fundamental question: what is the real important of determining accurately and precisely such a minute amount of one or few chemical marker(s) in a herbal medicine (except for toxic ingredients)?…”

Section: Quantification Issue Of Ersmentioning

confidence: 99%

The Prospect of Application of Extractive Reference Substance of Chinese Herbal Medicines

Xie¹,

Ma²,

Tu³

et al. 2013

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The emerging development of Extractive Reference Substance (ERS) is a methodology that meets the needs for quality control for Chinese Herbal Medicines (CHM) and respects the holistic viewpoint of Traditional Chinese Medicine (TCM) and its clinical use of multiple ingredients with synergistic effects. The convention of using just a selected few Chemical Reference Substances (CRS) cannot adequately assess the quality of intact CHM. A validated chemical spectrum of an ERS provides the global characteristics in order to more specifically identify and assess targeted CHM. This paper describes the fundamental concepts, potential significance, and basic criteria of ERS, along with methods of preparation and calibration. Given the diversity of CHM, the various problems that will occur in establishing the proper process of ERS will need to be solved in a step by step manner. The ERSs of Ziziphi spinosae semen and ERS of Fritillaria thunbergii bulbus are given as examples of the development of ERS and demonstrate why we are optimistic about the utility of this approach.

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“…Initiate such an engineer needs deliberate design and pain taking practice. A standard operation procedure and peer-to-peer methodology validation through coordination of QC laboratories will be necessary [18].…”

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confidence: 99%

Chromatographic Fingerprinting and Metabolomics for Quality Control of TCM

Liang¹,

Xie²,

Chan³

2010

CCHTS

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Chromatographic fingerprinting technique of traditional Chinese medicine (TCM) has proved to be a comprehensive strategy for assessing the intact quality of herbal medicine. In general, one could use the chromatographic techniques to obtain a relatively complete picture of herbal medicines, which are in common called chromatographic fingerprints of herbal medicines to represent the so-called phytoequivalence. Based on this, the features of chromatographic fingerprints of herbal medicines have been discussed in some detail. The technique based on chromatographic fingerprinting is essentially a kind of high-throughput and integral tools to explore the complexity of herbal medicines. In order to further control the comprehensive quality of TCMs, some new strategies are proposed to trace the chemical changes of chromatographic fingerprints both in product processing and/or after their administration by modern chromatographic techniques and chemometrics. Combined with metabolomics, it seems possible for one to reveal the working mechanism of TCMs and to further control their intrinsic quality. Finally, the intensive study of chromatographic fingerprinting coupled with multivariate analysis tools developed in bioinformatics and chemometrics are emphasized in order to achieve the aim to reveal the working mechanisms of TCMs and to further control and strengthen TCMs' intrinsic quality in a comprehensive manner.

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Herbal Reference Standards

Cited by 11 publications

References 5 publications

Effective Isolation of Picrocrocin and Crocins from Saffron: From HPTLC to Working Standard Obtaining

Effective Isolation of Picrocrocin and Crocins from Saffron: From HPTLC to Working Standard Obtaining

The Prospect of Application of Extractive Reference Substance of Chinese Herbal Medicines

Chromatographic Fingerprinting and Metabolomics for Quality Control of TCM

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