Herbal remedies improve the strength of repairing ligament in a rat model

The essential oil of Croton zehntneri and trans-anethole improves cutaneous wound healing

“…3D and E) was observed between EOCz-and AT-treated groups, suggesting that AT is fundamental for EOCz wound healing activity, primarily in the underlying molecular mechanism of extracellular matrix remodelling promoted by EOCz treatment. In accordance with our data, previous studies have shown that herbal extracts might enhance the wound repair process by stimulation of fibroblast motility from the wound edges to the wound sites, cellular proliferation and the consequent production of collagen (Fung and Ng, 2005). Atiba et al (2011) showed that Aloe vera accelerated wound contraction in diabetic rats by increasing the migration of fibroblasts and endothelial cells stimulated by transforming growth factor (TGFb1) and vascular endothelial grown factor (VEGF).…”

Effects of Herbal Application on the Ultrastructural Morphology of Repairing Medial Collateral Ligament in a Rat Model

“…These herbal-treated ligaments had better strength than those treated with laser therapy [17,18]. We have found that a therapeutic laser facilitated restoration of collagen fibril size and improved biomechanical properties [18,19].…”

“…In a recent study, we found that an externally applied herbal remedy improved the biomechanical strength of healing ligaments in vivo at both 3 weeks and 6 weeks postinjury [17]. These herbal-treated ligaments had better strength than those treated with laser therapy [17,18].…”

“…Following an established protocol [17][18][19], all surgical procedures were carried out under general anesthesia with intraperitoneal injection of a mixture of ketamine (100 mg/ml) (Alfasan International, Woerden, The Netherlands) and xylazine (20 mg/ml) (Alfasan International). The dosages of the drugs applied were calculated with the ratio of 8 mg ketamine per 100 g and 0.8 mg xylazine per 100 g of the animal's weight.…”

“…Each phase has its unique function and characteristics in preparation for the next phase. We are interested in the repair (3 weeks postinjury) and early remodeling phases (6 weeks postinjury), because we have found significant biomechanical improvements of healing ligaments after herbal treatment at these time intervals [17].…”