Conservation tillage adoption continues to be threatened by glyphosate and acetolactate synthase-resistant Palmer amaranth and other troublesome weeds. Field experiments were conducted from autumn 2010 through crop harvest in 2013 at two locations in Alabama to evaluate the effect of integrated management practices on weed control and seed cotton yield in glyphosate-resistant cotton. The effects of a cereal rye cover crop using high or low biomass residue, followed by wide or narrow within-row strip-tillage, and three PRE herbicide regimes were evaluated. The three PRE regimes were: 1) pendimethalin at 0.84 kg ae ha-1 plus fomesafen at 0.28 kg ai ha-1 applied broadcast, 2) pendimethalin plus fomesafen applied banded on the row, or 3) no PRE. Each PRE treatment was followed by (fb) glyphosate (1.12 kg ae ha-1) applied POST fb a LAYBY applications of diuron (1.12 kg ai ha-1) plus MSMA (2.24 kg ai ha-1). Low residue plots ranged in biomass from 85 to 464 kg ha-1, while high biomass plots ranged from 3119 to 6929 kg ha-1. In most comparisons, surface disturbance width, residue amount, and soil applied herbicide placement did not influence within-row weed control; however, broadcast PRE resulted in increased carpetweed, large crabgrass, Palmer amaranth, tall morningglory, and yellow nutsedge weed control in row middles compared to plots receiving banded PRE. In addition, high residue increased carpetweed, common purslane, large crabgrass, Palmer amaranth, sicklepod, and tall morningglory weed control between rows. Use of banded PRE herbicides resulted in equivalent yield and revenue in four of six comparisons compared to those with broadcast PRE herbicide application; however, this would likely result in many between row weed escapes. Thus, conservation tillage cotton would benefit from broadcast soil-applied herbicide applications regardless of residue amount and tillage width when infested with Palmer amaranth and other troublesome weed species.