In the wheat crop,pre-harvest desiccation with herbicides caninfluencethe productivity and physiological seed quality.The study aimed to quantify the yield, physiological seed quality,andresidue in wheat seeds.The experimental design was a randomized block designina 2x2x6 factorial, being thefactor A constituting of wheat cultivars (BRS 177 e BRS Umbu),the factor B application stages (before and after physiological maturation) and, factor C desiccation with different herbicides (2,4-D, paraquat, glyphosate, ammonium glufosinate, metsulfuron-methyl, and control) with four replications.The variables analyzed were thethousand seedsweight, hectoliter weight, number of antheciumper spike, seed yield, physiological seed quality by the vigortestsand standard germination, and residue in wheat seeds after the application of herbicides in pre-harvest.The desiccation in pre-harvest herbicide held at a later stage after physiological maturity, in general, does not affect the physiological quality and seed yield of BRS Umbu and BRS 177 cultivars. The application of methyl-metsulfuronand paraquat does not show residual effects on the seed independent of the application stage, while the application of ammonium glufosinate, glyphosate, and 2,4-D,when applied before the physiological maturity result residue levels in wheat seed.