Herbometallic nano-drug inducing metastatic growth inhibition in breast cancer through intracellular energy depletion

Ruidas, Bhuban; Sur, Tapas Kumar; Pal, Kunal; Chaudhury, Sutapa Som; Prasad, Parash; Sinha, Koel; Sarkar, Prasanta Kumar; Das, Pritha; Mukhopadhyay, Chitrangada Das

doi:10.1007/s11033-020-05467-7

Cited by 17 publications

(9 citation statements)

References 60 publications

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“…1a). In our previous report, we have shown that Palmitate-BSA alone can elevate the intracellular OCR and ECAR rate in breast cancer cells [34]. In this current experiment, intracellular basal and maximal respiration rate were decreased about 23.78% and 68.69% respectively in presence of QT-30 compared to control.…”

Section: Mitochondrial Respiration and Total Glycolysissupporting

confidence: 50%

“…Seahorse XFe24 Extracellular Flux Analyzer (Seahorse Bioscience, North Billerica, MA, USA) checked the intracellular Mito and Glyco-stress in 24 XF well plates via. The investigation of overall oxygen consumption rate (OCR) and extracellular acidi cation rate (ECAR) in MDA-MB-231 cells respectively [34].…”

Section: Intracellular Mito and Glyco-stress Analysismentioning

confidence: 99%

“…Kar Medical College, Kolkata, India. A detailed animal care and use were reported earlier [34]. Moreover, a successive in-vivo anticancer assessment including toxicity pro ling and therapeutic dosage con rmation were achieved following standard protocols (Supporting information).…”

Section: Animalsmentioning

confidence: 99%

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Quercetin: Silent Retarder of Fatty Acid Oxidation in Breast Cancer Metastasis Through Steering of Mitochondrial CPT1

Ruidas

Sur

Mukhopadhyay

et al. 2021

Preprint

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Recent evidence concreted that maximum energy in metastatic breast cancer progression is supplied by fatty acid oxidation (FAO) governed by a rate-limiting enzyme, carnitine palmitoyltransferase 1 (CPT1). Therefore, active limitation of FAO could be an emerging aspect to inhibit breast cancer progression. Herein, for the first time we have introduced Quercetin (QT) from a non-dietary source (Mikania micrantha Kunth) to seize the FAO in triple-negative breast cancer cells (TNBC) through an active targeting of CPT1. Apart from successive molecular quantification, QT has resulted a significant reduction in the intracellular mitochondrial respiration and glycolytic function limiting extensive ATP production. In turn, QT has elevated the reactive oxygen species (ROS) and depleted antioxidant level to induce anti-metastatic and cell apoptosis activities. Real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) investigated the FAO associated gene expression resulting significant depletion in FAO which were further confirmed through the successful in-silico molecular docking prediction for active binding potentiality of QT to CPT1. Subsequently, QT has shown an excellent in-vivo antitumor activities through the altered lipid profile and oxidative stress healing capabilities in female breast cancer BALB/c mice model. Therefore, all the obtained data significantly grounded the fact that QT could be a promising metabolism-targeted breast cancer therapeutics.

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Section: Mitochondrial Respiration and Total Glycolysissupporting

confidence: 50%

Section: Intracellular Mito and Glyco-stress Analysismentioning

confidence: 99%

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Quercetin: Silent Retarder of Fatty Acid Oxidation in Breast Cancer Metastasis Through Steering of Mitochondrial CPT1

Ruidas

Sur

Mukhopadhyay

et al. 2021

Preprint

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“…A branch of Ayurveda called “Rasashastra” deals with the preparation and therapeutic applications of metallic and mineral compounds, together with various organic materials. They are processed after repeated heating where material is reduced into metal or mineral ashes ( Bhasmas ), which then turn into nanoparticles ( Ruidas et al (2020) ). Several Ayurvedic Bhasma preparations are effective through sublingual and oral routes due to better bioavailability and absorption.…”

Section: Ayurvedic Bhasmas Against Sars-cov-2mentioning

confidence: 99%

Mechanistic insights from the review and evaluation of ayurvedic herbal medicines for the prevention and management of COVID-19 patients

Sarkar¹,

Mukhopadhyay

2022

Journal of Herbal Medicine

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“…Various treatment strategies, such as conventional drug treatment, plasma therapy, and vaccine development, have been proposed for COVID-19 treatment [ 13 , 14 ]. In this context, complementary and alternative medicine, such as Ayurveda, have also gained immense interest despite adequate clinical evidence [ 15 ] of their beneficial actions such as generation of herd immunity, and anticancer and antimicrobial activities [ 16 , 17 ]. Recent reports have suggested that Ayurvedic treatment, involving an in-depth therapeutic strategy, can efficiently treat COVID-19 [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 rhapsody: Rage towards advanced diagnostics and therapeutic strategy

Sinha

Chaudhury

Sharma

et al. 2021

Journal of Pharmaceutical Analysis

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The deadly global outbreak of COVID-19 has forged an unrivaled threat to human civilization. Contemplating its profuse impact, initial risk management and therapies are needed, as well as rapid detection strategies alongside treatments with existing drugs or traditional treatments to provide better clinical support for critical patients. Conventional detection techniques have been considered but do not sufficiently meet the current challenges of effective COVID-19 diagnosis. Therefore, several modern techniques including point-of-care diagnosis with a biosensor, clustered regularly interspaced short palindromic repeats (CRISPR)-affiliated proteins that function as nuclease enzyme (Cas) technology, next-generation sequencing, and serological, digital, and imaging approaches have delivered improved and noteworthy success compared to that using traditional strategies. Conventional drug treatment, plasma therapy, and vaccine development are also ongoing. However, alternative medicines including Ayurveda, herbal drugs, homeopathy, and Unani have also been enlisted as prominent treatment strategies for developing herd immunity and physical defenses against COVID-19. All considered, this review can help develop rapid and simplified diagnostic strategies, as well as advanced evidence-based modern therapeutic approaches that will aid in combating the global pandemic.

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Herbometallic nano-drug inducing metastatic growth inhibition in breast cancer through intracellular energy depletion

Cited by 17 publications

References 60 publications

Quercetin: Silent Retarder of Fatty Acid Oxidation in Breast Cancer Metastasis Through Steering of Mitochondrial CPT1

Quercetin: Silent Retarder of Fatty Acid Oxidation in Breast Cancer Metastasis Through Steering of Mitochondrial CPT1

Mechanistic insights from the review and evaluation of ayurvedic herbal medicines for the prevention and management of COVID-19 patients

COVID-19 rhapsody: Rage towards advanced diagnostics and therapeutic strategy

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