Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery

Zhou, Zilan; Badkas, Apurva; Stevenson, Max; Lee, Joo-Youp; Leung, Yuet-Kin

doi:10.1016/j.ijpharm.2015.03.081

Cited by 97 publications

(58 citation statements)

References 39 publications

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“…Breast cancer [178] So far, PLGA scaffolds have been mainly tested in the regeneration of cartilage and bone using different types of cells and molecules. Chang et al investigated a cell-based approach by seeding autologous endothelial progenitor cells (EPCs) into the PLGA scaffold to repair a full-thickness osteochondral defect in rabbits.…”

Section: Docetaxelmentioning

confidence: 99%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

214

133

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Poly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix. Moreover, its chemical modification with other polymers or bioconjugation with molecules may render PLGA with functional properties that make it the Holy Grail among the synthetic polymers to be applied in the biomedical field. In this review, the physical–chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields. A particular focus is given to successful examples of products already on the market or at the late stages of trials, reinforcing the potential of this polymer in the biomedical field.

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Section: Docetaxelmentioning

confidence: 99%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

214

133

View full text Add to dashboard Cite

show abstract

“…Smart materials are designed to respond favorably to various external stimuli such as pH, temperature and light by changing their properties [7,9,10]. The pH-sensitive polymers, in particular, have been given attention in recent years for various pharmaceutical applications [11][12][13]. Literature sources is abundant with examples of number of pH-responsive polymeric materials that have been prepared from synthetic as well as natural sources and used in controlled release of drugs [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…The pH-sensitive polymers, in particular, have been given attention in recent years for various pharmaceutical applications [11][12][13]. Literature sources is abundant with examples of number of pH-responsive polymeric materials that have been prepared from synthetic as well as natural sources and used in controlled release of drugs [11][12][13][14][15][16]. However, it is to be noted that appropriate designing of a new pH-responsive matrix always requires maintaining the correlation between material cross-linking properties and swelling characteristics [5].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

Barik

Patnaik²,

Parhi

et al. 2017

Polym. Bull.

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A new pH-responsive carrier matrix was designed from combination of shellac (Sh), hydroxpropylmethylcellulose (HPMC) and acrylic acid (AA). Characterization of materials was done using various advanced instrumentation techniques. The kinetics of thermal decomposition of materials were studied and compared using Coats-Redfern (CR) and Kissinger-Akahira-Sunose (KAS) mathematical models. The Arrhenius equations for thermal decomposition of shellac and chemically modified shellac (Sh-HPMC-AA) were computed to be k = (3.4 9 10 21 ) e -159.9/RT and k = (141.8) e -19.6/RT s -1 , respectively. The pHresponsive characteristics of Sh-HPMC-AA shows 288% swelling ratio. Further, the controlled release of 5-amino salicylic acid (5-ASA) was studied in buffer medium and Fick's diffusion equation was applied for calculation of transport phenomenon. The enzymatic degradation study of Sh-HPMC-AA is also reported.

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“…Hence, micelles might eventually be digested by enzymes or transported out of the cells via exocytosis, if they cannot escape from these acidic compartments. 19 Therefore, it is urgent to find a new micelle-delivery system for intracellular targeting based on triggered release mechanism to achieve maximal therapeutic efficacy. 20,21 It has been reported that the extracellular pH of most of the tumor tissues (pH 6.5-7.2) is lower than that of normal tissues and blood stream (pH 7.4).…”

mentioning

confidence: 99%

pH-sensitive and folic acid-targeted MPEG-PHIS/FA-PEG-VE mixed micelles for the delivery of PTX-VE and their antitumor activity

Yan¹,

Li²,

Zhu³

et al. 2017

IJN

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The aim of this study was to simultaneously introduce pH sensitivity and folic acid (FA) targeting into a micelle system to achieve quick drug release and to enhance its accumulation in tumor cells. Paclitaxel-(+)-α-tocopherol (PTX-VE)-loaded mixed micelles (PHIS/FA/PM) fabricated by poly(ethylene glycol) methyl ether-poly(histidine) (MPEG-PHIS) and folic acid-poly(ethylene glycol)-(+)-α-tocopherol (FA-PEG-VE) were characterized by dynamic light scattering and transmission electron microscopy (TEM). The mixed micelles had a spherical morphology with an average diameter of 137.0±6.70 nm and a zeta potential of −48.7±4.25 mV. The drug encapsulation and loading efficiencies were 91.06%±2.45% and 5.28%±0.30%, respectively. The pH sensitivity was confirmed by changes in particle size, critical micelle concentration, and transmittance as a function of pH. MTT assay showed that PHIS/FA/PM had higher cytotoxicity at pH 6.0 than at pH 7.4, and lower cytotoxicity in the presence of free FA. Confocal laser scanning microscope images demonstrated a time-dependent and FA-inhibited cellular uptake. In vivo imaging confirmed that the mixed micelles targeted accumulation at tumor sites and the tumor inhibition rate was 85.97%. The results proved that the mixed micelle system fabricated by MPEG-PHIS and FA-PEG-VE is a promising approach to improve antitumor efficacy.

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Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery

Cited by 97 publications

References 39 publications

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

pH-sensitive and folic acid-targeted MPEG-PHIS/FA-PEG-VE mixed micelles for the delivery of PTX-VE and their antitumor activity

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