Hereditary afibrinogenemia: A literature review and clinical observations

Yakovleva, E. V.; Surin, V. L.; Selivanova, D. S.; Sergeeva, A. M.; Gonсharova, M V; Demidova, Ekaterina; Soboleva, N P; Makhinya, S A; Dezhenkova, A V; Лихачева, Е. А.; Zozulya, Nadezhda

doi:10.17116/terarkh20168812120-125

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…In the nematode Caenorhabditis elegans, the intestinal lipid metabolic sensors SBP-1 and MDT-15 respond to simulated microgravity, with RNAi knockdown of sbp-1 and mdt-15 reducing lipid toxicity 12 . Spaceflight metabolic studies from the Bion space program (Kosmos 605, 690, 782, 936 and 1887 (1973-87)) [13][14][15] characterised rats as hyperlipidemic, with spaceflight inducing elevated serum or hepatic fatty acids, and substantial increases in cholesterol (67%). Similar lipid dysregulation, suggestive of non-alcoholic fatty liver disease (NFALD), has been a consistently observed mammalian response to spaceflight alongside aligned disruption of insulin metabolism and glucose homeostasis [16][17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Spaceflight alters host-gut microbiota interactions

Brereton,

Gonzalez,

Lee

et al. 2024

Preprint

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The rodent habitat on the International Space Station has provided crucial insights into the impact of spaceflight on mammals, inducing symptoms characteristic of liver disease, insulin resistance, osteopenia, and myopathy. Although these physiological responses can involve the microbiome when observed on Earth, changes in host-microbiota interactions during spaceflight are still being elucidated. Here, we explore murine gut microbiota and host gene expression in the colon and liver after 29 and 56-days of spaceflight using multiomic analyses of the Rodent Research 6 mission. Hybrid amplicon and whole metagenome sequencing revealed significant spaceflight-associated changes in 43 microbiome species, including relative reductions in bile acid and butyrate metabolising bacteria like Extibacter muris and Dysosmobacter welbionis. Functional prediction indicate over-representation of fatty acid and bile acid metabolism, extracellular matrix interactions, and antibiotic resistance genes within the gut microbiome, while host intestinal and hepatic gene expression described corresponding changes to host bile acid and energy metabolism, and immune suppression from spaceflight. Taken together, these changes imply that interactions at the host-gut microbiome interface contribute to spaceflight pathology and highlight how these interactions might critically influence human health and the feasibility of long-duration spaceflight.

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Section: Introductionmentioning

confidence: 99%

Spaceflight alters host-gut microbiota interactions

Brereton,

Gonzalez,

Lee

et al. 2024

Preprint

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Spaceflight alters host-gut microbiota interactions

Gonzalez,

Lee,

Tierney

et al. 2024

Preprint

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The rodent habitat on the International Space Station has provided crucial insights into the impact of spaceflight on mammals, including observation of symptoms characteristic of liver disease, insulin resistance, osteopenia and myopathy. Although these physiological responses can involve the microbiome when observed on Earth, changes in host-microbiota interactions during spaceflight are still being elucidated. Here, NASA GeneLab multiomic data from the Rodent Research 6 mission are used to determine changes to gut microbiota and murine host colon and liver gene expression after 29 and 56-days of spaceflight. Using hybrid amplicon and whole metagenome sequencing analysis, significant spaceflight-associated alterations to 42 microbiome species were identified. These included relative reductions of bacteria associated with bile acid and butyrate metabolism, such as Extibacter muris and Dysosmobacter welbionis. Functional prediction suggested over-representation of fatty acid and bile acid metabolism, extracellular matrix interactions, and antibiotic resistance genes within the gut microbiome, while host intestinal and hepatic gene expression described corresponding changes to host bile acid and energy metabolism, and immune suppression from spaceflight. Taken together, these changes imply that interactions at the host-gut microbiome interface contribute to spaceflight pathology and highlight how these interactions might critically influence human health and the feasibility of long-duration spaceflight.

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Reference values of activated partial thromboplastin time, Quick`s value, INR, thrombin time, fibrinogen, antithrombin and II, V, VII, VIII, IX, X, XI and XII coagulation factors determined with automated Sysmex CS-2000i analyzer

Горгидзе¹,

Mamleeva²,

Pimenov

et al. 2023

Medicinskij alfavit

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The article defines reference values for activated partial thromboplastin time, Quick’s value, INR, thrombin time, fibrinogen, antithrombin and II, V, VII, VIII, IX, X, XI and XII coagulation factors, according to existing standards on the automated Sysmex CS‑2000i analyzer.The aim of the study. To determine reference values for routine and specific parameters of the hemostasis, which may vary depending on the type of analyzer and utilized reagents.Materials and methods. After receiving informed consent from donors for medical survey and blood donation, blood samples were obtained from 100 healthy donors: 64 (64%) males и 36 (36%) females. We established reference values with the Sysmex CS‑2000i (Sysmex, Japan) hemostasis analyzer and reagents from Siemens (Siemens Healthcare, Germany).Results. The data obtained were compared with the literature data and the data presented in the instructions for the reagents used. The results obtained for activated partial thromboplastin time (23.59–35.69 sec), fibrinogen (1.67–3.59 g/l) and antithrombin (67.65–114.89%) are comparable to the available data. There are no data on other studied parameters of hemostasis for the Sysmex CS‑2000i analyzer and the reagents used in the work. The obtained reference intervals are consistent with the recommendations of the manufacturer.Conclusions. Reference values vary significantly depending on the analytical systems and reagent kits used, which confirms the need for local derivation or validation of reference intervals for each specific analytical system and in each laboratory.

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Hereditary afibrinogenemia: A literature review and clinical observations

Cited by 4 publications

References 20 publications

Spaceflight alters host-gut microbiota interactions

Spaceflight alters host-gut microbiota interactions

Spaceflight alters host-gut microbiota interactions

Reference values of activated partial thromboplastin time, Quick`s value, INR, thrombin time, fibrinogen, antithrombin and II, V, VII, VIII, IX, X, XI and XII coagulation factors determined with automated Sysmex CS-2000i analyzer

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