Hereditary melanoma and predictive genetic testing: why not?

Riedijk, Sam; Snoo, Femke A. de; Dijk, S. van; Bergman, Wilma; Haeringen, Arie van; Silberg, Stanley L.; Elderen, T.M.T. van; Tibben, Aad

doi:10.1002/pon.901

Cited by 27 publications

(22 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Test decliners were more worried of the test result, of facing difficult decisions after testing and did not expect the test result would relieve their worries over melanoma. This is in line with our earlier study in which we found older age, parenthood and lower anxiety levels to differentiate counselees from non-visitors [21].…”

Section: Discussionsupporting

confidence: 93%

“…The p16-Leiden families reside in a relatively secluded religious area of the Netherlands. Although we did not have information about the motivation of those who did not participate in the psychological part of our study we have previously reported on individuals at risk who did not opt for counseling at all and found that these individuals also had distress levels below population level and did not opt for counseling out of rational and emotional motives [21]. However, the findings may be different for other melanoma families, for which the causative gene and its risk estimates may not be as well established.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Genetic testing in familial melanoma: uptake and implications

et al. 2008

View full text Add to dashboard Cite

Objective: We report on the uptake and psychological impact of p16-Leiden genetic testing to contribute to a greater understanding of counseling melanoma families.Methods: Within a defined research setting, genetic counseling and testing were offered to members of p16-Leiden-positive melanoma pedigrees, at risk of carrying a gene defect associated with an increased risk of melanoma and pancreatic cancer.Results: One hundred and eighty-four individuals sought counseling, of which 141 (77%) opted for genetic testing. Uptake of genetic counseling and testing, and psychological motivation was evaluated in 94 (57%) individuals. Higher pre-test risk of carrying the mutation and older age proved significantly predictive for counseling uptake. Age was predictive for test acceptance, whereas fearful test expectancies predicted test decline. Counselees had lower distress levels than those reported in other oncogenetic testing settings.Conclusion: We are the first to report on genetic testing for familial melanoma. Following the first counseling session, we found a relatively high uptake rate for p16-Leiden testing and no clinically worrisome levels of distress.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Genetic testing in familial melanoma: uptake and implications

et al. 2008

View full text Add to dashboard Cite

show abstract

“…We found that respondents experienced annual EUS and MRI investigations as ‘not’ uncomfortable or only ‘slightly’ uncomfortable and dread their next EUS investigations less as surveillance progressed while having decreasing worries about cancer and having normal and stable levels of anxiety and depression. These results are in line with the psychological burden of surveillance for other inherited forms of cancer .…”

Section: Discussionsupporting

confidence: 82%

Repeated participation in pancreatic cancer surveillance by high‐risk individuals imposes low psychological burden

et al. 2015

View full text Add to dashboard Cite

show abstract

“…This was assessed using 20 items generated from the published literature, 62 an expert panel, and our previous findings. 35,36 Participants were asked to indicate the extent to which each possible reason for not attending genetic counseling reflected their experience, using a 4-point Likert scale from 0 ("No agreement") to 3 ("Completely agree").…”

Section: Reasons For Not Attending Genetic Counselingmentioning

confidence: 99%

Genetic testing for melanoma risk: a prospective cohort study of uptake and outcomes among Australian families

Kasparian

Meiser

Butow

et al. 2009

Genetics in Medicine

119

View full text Add to dashboard Cite

Purpose: The aim of this prospective cohort study was to examine uptake and psychological, behavioral, and cognitive outcomes of genetic testing for melanoma risk among individuals with a known familyspecific CDKN2A mutation. Methods: A total of 119 individuals were ascertained via a genetic epidemiological study and completed a series of mailed, self-administered questionnaires at multiple time points, including notification of genetic test availability, and 2 weeks and 12 months after receipt of genetic test results (for "test participants"), or 12 months after notification (for "decliners"). Results: Since January 2005, 21% of participants (n ϭ 25) have undergone genetic testing, with 75% of those who have received results identified as mutation carriers (n ϭ 15). Factors associated with uptake of genetic counseling included perceived susceptibility to melanoma (odds ratio ϭ 3.60, P ϭ 0.0008), and fatalistic beliefs about melanoma (odds ratio ϭ 0.57, P ϭ 0.005). Compared with baseline, carriers reported significantly reduced anxiety scores at 2 weeks, and reduced depression scores at 2 weeks and 12 months, after receipt of genetic test results. Carriers also reported a significantly greater frequency of clinical skin examination at 12-month follow-up compared with decliners ( 2 ϭ 5.70, P ϭ 0.02). No hypothesis testing was carried out for noncarriers because of their limited number. Conclusion: These data provide preliminary evidence for healthy psychological, behavioral, and cognitive adjustment after participation in genetic testing for melanoma risk. Genet Med 2009:11(4): 265-278.

show abstract

Hereditary melanoma and predictive genetic testing: why not?

Cited by 27 publications

References 27 publications

Genetic testing in familial melanoma: uptake and implications

Genetic testing in familial melanoma: uptake and implications

Repeated participation in pancreatic cancer surveillance by high‐risk individuals imposes low psychological burden

Genetic testing for melanoma risk: a prospective cohort study of uptake and outcomes among Australian families

Contact Info

Product

Resources

About