Hereditary nonpolyposis colorectal cancer in a Navajo Indian family

Lynch, Henry T.; Drouhard, T.; Schuelke, Guy S.; Biscone, Karen A.; Lynch, Jane F.; Danes, B. Shannon

doi:10.1016/0165-4608(85)90164-5

Cited by 36 publications

(17 citation statements)

References 2 publications

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“…For major adult cancers, such as breast and colorectal cancers, this percentage may be 1–2% or less [11, 12]due to the low population frequency of known inherited susceptibility mutations [13, 14]. Although overall population prevalence is low [15], numerous studies indicate that cancer susceptibility mutations occur in diverse populations and demographic subgroups [16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39]. Thus risk assessment, genetic counseling, and testing [40]may benefit individuals across a range of age, gender, and race/ethnic subgroups.…”

Section: Introductionmentioning

confidence: 99%

Awareness of Genetic Testing for Increased Cancer Risk in the Year 2000 National Health Interview Survey

Wideroff¹,

Vadaparampil²,

Breen³

et al. 2003

Public Health Genomics

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Objectives: This study explores factors associated with differential awareness of genetic tests for increased cancer risk in the US. Methods: 27,405 respondents from the 2000 National Health Interview Survey, ages 25+, were asked if they had heard of these tests. Results: 44.4% said ‘yes’, including 49.9% of whites, 32.9% of African-Americans, 32.3% of American Indians/Alaskan Natives, 28.0% of Asian/Pacific Islanders, and 20.6% of Hispanics. In multivariate analysis, test awareness was significantly associated with higher education, white race, age <60 years, female gender, private health insurance, personal or parent’s history of certain cancers, physical activity, and vitamin/supplement use, among other factors. Conclusions: The survey showed which population subgroups may lack access to cancer genetics information and may therefore benefit from targeted strategies to ensure risk-appropriate utilization of genetic counseling and testing.

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Section: Introductionmentioning

confidence: 99%

Awareness of Genetic Testing for Increased Cancer Risk in the Year 2000 National Health Interview Survey

Wideroff¹,

Vadaparampil²,

Breen³

et al. 2003

Public Health Genomics

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“…HNPCC has been reported all over the world, affecting all human ethnic groups. Reports from different parts of the world indicate that the clinical expression of the disease may vary between countries (Lynch et al, 1985;Sarroca et al, 1978). For example, it is well-known that HNPCC families identified in Asia include stomach cancer more frequently than families identified in Western countries (Baba, 1997).…”

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confidence: 99%

Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing

Park¹,

Park²,

Wijnen

et al. 1999

Int. J. Cancer

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“…The proportion of hereditary nonpolyposis colorectal cancer (HNPCC) or familial colorectal cancer among all colorectal cancers varies by country, with rates ranging from 1% to 10% among all colorectal cancer patients, (median, 2-5%) (Mecklin and Ponz de Leon, 1994). Although HNPCC has been reported in many populations, including Europeans, White and Indian Americans, Asians, Australasians and South Americans (Bamezei et al, 1984;Jass and Stewart 1992;Lynch et al, 1985;Mecklin, 1987;Mecklin and Jarvinen, 1991;Sarroca et al, 1978;Ushio, 1985;Vasen et al, 1990), no studies have been published on HNPCC or familial colorectal cancer among Egyptians. Previous studies have shown that colorectal cancer patients under age 30 represent more than 20% of the total colorectal cancer patients in Egypt (Abou-El-Eneine et al, 1986;El-Ghoneimy et al, 1989;Shawky et al, 1992).…”

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confidence: 99%

Familial aggregation of colorectal cancer in Egypt

et al. 1998

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We have investigated the familial aggregation of colorectal cancer and hereditary nonpolyposis colorectal cancer (HNPCC) in Egypt because of the high incidence of colorectal cancer in Egyptian children and young adults and the prevalence of consanguinity there. In a pilot study, we conducted detailed interviews with 111 Egyptian colorectal cancer patients and 111 healthy Egyptian controls about their family histories of colorectal cancer, and other cancers, consanguinity, age at diagnosis, symptoms and recurrence. Eight patients (7.2%) had one or more first‐ or second‐degree relatives under age 40 with colorectal cancer, suggestive of HNPCC by the Amsterdam criteria. One of these families had a typical history of HNPCC, with 4 relatives having colorectal cancer in 3 generations; 3 of these relatives were younger than age 45 at colon cancer diagnosis, and other relatives had extracolonic tumors. Another 14 patients (12.6%) had a first‐ or second‐degree relative with a family history of other neoplasms such as endometrial, urinary and hepatobiliary cancers that could also be related to HNPCC. Four patients with early‐onset colon cancer and a family history of other HNPCC‐related cancers reported that their parents were first‐degree cousins. Int. J. Cancer 77:811–816, 1998.© 1998 Wiley‐Liss, Inc.

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Hereditary nonpolyposis colorectal cancer in a Navajo Indian family

Cited by 36 publications

References 2 publications

Awareness of Genetic Testing for Increased Cancer Risk in the Year 2000 National Health Interview Survey

Awareness of Genetic Testing for Increased Cancer Risk in the Year 2000 National Health Interview Survey

Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing

Familial aggregation of colorectal cancer in Egypt

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