Hereditary Palmoplantar (Epidermolytic) Keratoderma: Illustration Through a Familial Report

Abstract

Hereditary palmoplantar keratoderma, a well-known clinical entity, is illustrated through a familial report of an unmarried young man who is the product of a consanguineous marriage (paternal and maternal grandmothers were sisters). The lesions were characterized by immense yellow waxy thickening of the skin surrounded by erythematous border (halo) and fissures/cracks associated with extensive scaling of the palms and soles. The lesions were bilateral and symmetrical. These features were supported by orthokeratotic hyperkeratosis hypergranulosis and acanthosis in hematoxylin-eosin stained tissue sections prepared from the soles. Mycelia/spores could not be identified on Periodic acid-Schiff (PAS) reaction. An autosomal dominant trait was revealed through family pedigree. An abridged update to recap the current status is highlighted.

The Spectrum of Skin Disease Among Indian Children

“…The physiologic dermatoses were mostly constituted by erythema toxicum neonatorum, a condition common in term infants (37). The rest were constituted by rare (38), and usually unrelated dermatoses, typical of a referral hospital setting (miscellaneous dermatoses) (Table 2).…”