Heritability of cardiac vagal control in 24‐h heart rate variability recordings: Influence of ceiling effects at low heart rates

Neijts, Melanie; Lien, René van; Kupper, Nina; Boomsma, Dorret I.; Willemsen, Gonneke; Geus, Eco J. C. de

doi:10.1111/psyp.12246

Cited by 25 publications

(28 citation statements)

References 114 publications

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“…However, the genetic factors influencing individual differences in resting versus stress‐response HR appear to be distinct [Ditto, ; Wu et al, ]. HRV is also moderately heritable, with estimates from four studies at around 50% [Riese et al, ; Wang et al, ; Su et al, ; Neijts et al, ], although heritability varied for different types of measures such as high versus low frequency spectral power. Unlike HR, 60–81% of the latent genetic influences were shared between resting and stress‐response HRV [Wang et al, ], possibly because variation in heart rate intrinsically reflects an organism's changing response to the immediate environment.…”

Section: Resultsmentioning

confidence: 99%

The genetics of anxiety‐related negative valence system traits

Savage

Sawyers

Roberson‐Nay

et al. 2016

American J of Med Genetics Pt B

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NIMH’s Research Domain Criteria (RDoC) domain of negative valence systems (NVS) captures constructs of negative affect such as fear and distress traditionally subsumed under the various internalizing disorders. Through its aims to capture dimensional measures that cut across diagnostic categories and are linked to underlying neurobiological systems, a large number of phenotypic constructs have been proposed as potential research targets. Since “genes” represent a central “unit of analysis” in the RDoC matrix, it is important for studies going forward to apply what is known about the genetics of these phenotypes as well as fill in the gaps of existing knowledge. This article reviews the extant genetic epidemiological data (twin studies, heritability) and molecular genetic association findings for a broad range of putative NVS phenotypic measures. We find that scant genetic epidemiological data is available for experimentally-derived measures such as attentional bias, peripheral physiology, or brain-based measures of threat response. The molecular genetic basis of NVS phenotypes is in its infancy, since most studies have focused on a small number of candidate genes selected for putative association to anxiety disorders (ADs). Thus, more research is required to provide a firm understanding of the genetic aspects of anxiety-related NVS constructs.

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Section: Resultsmentioning

confidence: 99%

The genetics of anxiety‐related negative valence system traits

Savage

Sawyers

Roberson‐Nay

et al. 2016

American J of Med Genetics Pt B

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“…Time domain measures of HRV showed heritability in a similar range (35–48%) (Kupper et al, 2004). Another twin study of time domain HRV measures based on 24-h ambulatory recordings yielded significant heritabilities of time domain variables ranging from46 to 57% and indicated a substantial overlap of genetic influences on two time domain HRV measures, standard deviation of the R-R intervals (SDNN) and the RMSSD (Neijts et al, 2014). A study using a nonlinear dynamical measure of HRV (approximate entropy) showed only a modest heritability of 40% (Snieder et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Genetic influences on heart rate variability

Golosheykin

Grant

Novak

et al. 2017

International Journal of Psychophysiology

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Heart rate variability (HRV) is the variation of cardiac inter-beat intervals over time resulting largely from the interplay between the sympathetic and parasympathetic branches of the autonomic nervous system. Individual differences in HRV are associated with emotion regulation, personality, psychopathology, cardiovascular health, and mortality. Previous studies have shown significant heritability of HRV measures. Here we extend genetic research on HRV by investigating sex differences in genetic underpinnings of HRV, the degree of genetic overlap among different measurement domains of HRV, and phenotypic and genetic relationships between HRV and the resting heart rate (HR). We performed electrocardiogram (ECG) recordings in a large population-representative sample of young adult twins (n = 1060 individuals) and computed HRV measures from three domains: time, frequency, and nonlinear dynamics. Genetic and environmental influences on HRV measures were estimated using linear structural equation modeling of twin data. The results showed that variability of HRV and HR measures can be accounted for by additive genetic and non-shared environmental influences (AE model), with no evidence for significant shared environmental effects. Heritability estimates ranged from 47 to 64%, with little difference across HRV measurement domains. Genetic influences did not differ between genders for most variables except the square root of the mean squared differences between successive R-R intervals (RMSSD, higher heritability in males) and the ratio of low to high frequency power (LF/HF, distinct genetic factors operating in males and females). The results indicate high phenotypic and especially genetic correlations between HRV measures from different domains, suggesting that >90% of genetic influences are shared across measures. Finally, about 40% of genetic variance in HRV was shared with HR. In conclusion, both HR and HRV measures are highly heritable traits in the general population of young adults, with high degree of genetic overlap across different measurement domains.

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“…Likewise resting RSA is substantially heritable with estimates ranging between 25 and 71 % (de Geus et al 2015; Neijts et al 2014). We replicate these findings in our sample (heart rate 68 %, RSA 58 %) with the heritability of resting heart rate very similar to a recent meta-analysis done by Wang et al (Wang et al 2015) and the heritability of resting RSA very similar to that found in a large non-overlapping study in adult Dutch twins (50 %) (Neijts et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Heritability of heart rate recovery and vagal rebound after exercise

et al. 2016

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PurposeThe prognostic power of heart rate recovery (HRR) after exercise has been well established but the exact origin of individual differences in HRR remains unclear. This study aims to estimate the heritability of HRR and vagal rebound after maximal exercise in adolescents. Furthermore, the role of voluntary regular exercise behavior (EB) in HRR and vagal rebound is tested.Methods491 healthy adolescent twins and their siblings were recruited for maximal exercise testing, followed by a standardized cooldown with measurement of the electrocardiogram and respiratory frequency. Immediate and long-term HRR (HRR60 and HRR180) and vagal rebound (heart rate variability in the respiratory frequency range) were assessed 1 and 3 min after exercise. Multivariate twin modeling was used to estimate heritability of all measured variables and to compute the genetic contribution to their covariance.ResultsHeritability of HRR60, HRR180 and immediate and long-term vagal rebound is 60 % (95 % CI: 48–67), 65 % (95 % CI: 54–73), 23 % (95 % CI: 11–35) and 3 % (95 % CI: 0–11), respectively. We find evidence for two separate genetic factors with one factor influencing overall cardiac vagal control, including resting heart rate and respiratory sinus arrhythmia, and a specific factor for cardiac vagal exercise recovery. EB was only modestly associated with resting heart rate (r = −0.27) and HRR (rHRR60 = 0.10; rHRR180 = 0.19) with very high genetic contribution to these associations (88–91 %).ConclusionsIndividual differences in HRR and immediate vagal rebound can to a large extent be explained by genetic factors. These innate cardiac vagal exercise recovery factors partly reflect the effects of heritable differences in EB.

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Heritability of cardiac vagal control in 24‐h heart rate variability recordings: Influence of ceiling effects at low heart rates

Cited by 25 publications

References 114 publications

The genetics of anxiety‐related negative valence system traits

The genetics of anxiety‐related negative valence system traits

Genetic influences on heart rate variability

Heritability of heart rate recovery and vagal rebound after exercise

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