Heritability of Plasma Cholesterol and Triglyceride Concentrations in Swine

Mersmann, Harry J.; Young, L. D.

doi:10.3181/00379727-182-42331

Cited by 28 publications

(20 citation statements)

References 15 publications

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“…The existence of a relevant amount of additive genetic variability for serum lipid traits in pigs has been demonstrated by Rothschild and Chapman [6] and Pond et al . [7], and subsequently corroborated in several divergent selection experiments [8,9]. …”

Section: Introductionmentioning

confidence: 64%

Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs

et al. 2011

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BackgroundSerum lipids are associated with many serious cardiovascular diseases and obesity problems. Many quantitative trait loci (QTL) have been reported in the pig mostly for performance traits but very few for the serum lipid traits. In contrast, remarkable numbers of QTL are mapped for serum lipids in humans and mice. Therefore, the objective of this research was to investigate the chromosomal regions influencing the serum level of the total cholesterol (CT), triglyceride (TG), high density protein cholesterol (HDL) and low density protein cholesterol (LDL) in pigs. For this purpose, a total of 330 animals from a Duroc × Pietrain F2 resource population were phenotyped for serum lipids using ELISA and were genotyped by using 122 microsatellite markers covering all porcine autosomes for QTL study in QTL Express. Blood sampling was performed at approximately 175 days before slaughter of the pig.ResultsMost of the traits were correlated with each other and were influenced by average daily gain, slaughter date and age. A total of 18 QTL including three QTL with imprinting effect were identified on 11 different porcine autosomes. Most of the QTL reached to 5% chromosome-wide (CW) level significance including a QTL at 5% experiment-wide (GW) and a QTL at 1% GW level significance. Of these QTL four were identified for both the CT and LDL and two QTL were identified for both the TG and LDL. Moreover, three chromosomal regions were detected for the HDL/LDL ratio in this study. One QTL for HDL on SSC2 and two QTL for TG on SSC11 and 17 were detected with imprinting effect. The highly significant QTL (1% GW) was detected for LDL at 82 cM on SSC1, whereas significant QTL (5% GW) was identified for HDL/LDL on SSC1 at 87 cM. Chromosomal regions with pleiotropic effects were detected for correlated traits on SSC1, 7 and 12. Most of the QTL identified for serum lipid traits correspond with the previously reported QTL for similar traits in other mammals. Two novel QTL on SSC16 for HDL and HDL/LDL ratio and an imprinted QTL on SSS17 for TG were detected in the pig for the first time.ConclusionThe newly identified QTL are potentially involved in lipid metabolism. The results of this work shed new light on the genetic background of serum lipid concentrations and these findings will be helpful to identify candidate genes in these QTL regions related to lipid metabolism and serum lipid concentrations in pigs.

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Section: Introductionmentioning

confidence: 64%

Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs

et al. 2011

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“…y Total protein = 7.6, 8.1, 8.0, and 8.0 g dL -1 in pigs fed 6.1 and 6.1, 6.1 and 8.9, 11.1 and 6.1, and 11.1 and 8.9 g lysine kg -1 diet combinations during the grower and finisher phases, respectively. (Pond et al 1986). The mechanisms are not clear, but the changes in lipoprotein composition and (or) transport that are taking place in lipid metabolism during the protein restriction may be responsible for the effect, as suggested by Pond et al (1986).…”

Section: Discussionmentioning

confidence: 99%

“…(Pond et al 1986). The mechanisms are not clear, but the changes in lipoprotein composition and (or) transport that are taking place in lipid metabolism during the protein restriction may be responsible for the effect, as suggested by Pond et al (1986).…”

Section: Discussionmentioning

confidence: 99%

Effect of early dietary amino acid restrictions on serum metabolites in pigs selected for lean growth efficiency

Mule¹,

Chiba²,

Fabian³

et al. 2006

Can. J. Anim. Sci.

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. Effect of early dietary amino acid restrictions on serum metabolites in pigs selected for lean growth efficiency. Can J. Anim. Sci. 86: 489-500. Thirty-two select line pigs for lean growth efficiency and 32 control line pigs (average 20 kg) were used in each of the two experiments to assess the effect of dietary amino acid restrictions during the grower phase on serum cholesterol, triglycerides, total protein, albumin, and glucose concentrations. In each experiment, 16 pens with two gilts and 16 pens with two castrated males per pen were assigned within the genetic line to grower (6.1 or 11.1 g lysine kg -1 ) and finisher diets (6.1 or 8.9 g lysine kg -1 ) in a 2 × 2 × 2 factorial arrangement in exp. 1, or grower diets (5.0, 7.0, 9.0, or 11.0 g lysine kg -1 ) in a 2 × 4 factorial arrangement of treatments in exp. 2. Pigs were offered common finisher diets in exp. 2. Serial blood samples were collected in both experiments. Serum cholesterol at the end of the grower phase was greater in the select line pigs in exp. 1 (P = 0.009) and pigs fed diets low in amino acids in exp. 2 (P = 0.005, 0.026, and 0.039 for linear, quadratic, and cubic, respectively). Serum cholesterol was correlated negatively with lysine intake (r = -0.38; P = 0.039) and serum urea nitrogen (r = -0.39; P = 0.032) in exp. 1 and positively with ultrasound backfat (r = 0.78; P = 0.001) in exp. 2. Serum cholesterol, however, may not reflect the cholesterol content of tissues or pork, except liver. At the end of the grower phase, pigs fed grower diets high in amino acids had greater serum total protein in exp. 2 (P = 0.040 and 0.093 for linear and quadratic, respectively) and albumin concentrations in exp. 1 (P = 0.001) and exp. 2 (linear, P = 0.001), and, at the end of the finisher phase, they had greater serum albumin in exp. 1 (P = 0.001) and seemed to have more total protein in exp. 2, even though there was a trend for the grower diet × genotype interaction (P = 0.095). The carryover effects of the grower diet during the realimentation phase seem to be contrary to the expected positive metabolite status of pigs exhibiting compensatory growth after a period of early dietary amino acid restrictions. On the other hand, higher serum total protein in exp. 2 (P = 0.041 and 0.001 at the end of the grower and finisher phases, respectively) and albumin concentrations at the end of the finisher phase in exp. 1 (P = 0.016) and exp. 2 (P = 0.059) in pigs selected for lean growth efficiency may be an indication that pigs utilized amino acids more efficiently for growth and protein accretion. Exploring fully the effect of dietary manipulations and genotypes on serum metabolites is obviously important, and the results of the present research may contribute to the development of the environmentally friendly, optimal feeding strategies for successful and sustainable pig production. Key words: Amino acid restrictions, genotypes, pigs, serum metabolitesMule, H. R., Chiba, L. I., Fabian, J., Kuhlers, D. L., Jungst, S. B., Frobish, L. T., Nadarajah, K., Bergen, W....

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“…The evidence points out that the pig is accepted as an appropriate animal model to access the relationship between plasma cholesterol concentration and coronary artery disease, because of its similarities to human (Pond et al, 1986;Stanton and Mersmann, 1986;Van et al, 1991). Due to the pressing research for human disease, the small-size pigs have been deemed to ideal subscriber.…”

Section: Discussionmentioning

confidence: 99%

Expression of HMGR and corresponding cholesterol content in tissues of two pig breeds

Liu

Fang

Lin

et al. 2009

Animal

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The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis. To study the expression of HMGR and corresponding cholesterol content in liver, adipose and muscle, six Chinese local breed (Huai pig) and Landrace pigs were selected. The results indicated that significant differences of cholesterol content in adipose ( P , 0.01), liver ( P , 0.05) and muscle ( P , 0.01) tissues were detected between pigs of differing genetic backgrounds. HMGR mRNA expression were noted for adipose, liver and muscle of the two vastly differing genetics. Moreover cholesterol content differed ( P , 0.01) among tissues across breed. Likewise, HMGR mRNA expression was different between adipose and liver tissues, muscle and liver tissues in both breeds; however, no difference was noted between adipose and muscle tissues. Results from this study indicate that cholesterol content and HMGR mRNA expression are higher in Huai pig tissues suggesting this gene is expressed in a breed-and tissue-dependent manner in pigs. Understanding the causes of variation in HMGR gene expression may provide crucial information about cholesterol biosynthesis.

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Heritability of Plasma Cholesterol and Triglyceride Concentrations in Swine

Cited by 28 publications

References 15 publications

Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs

Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs

Effect of early dietary amino acid restrictions on serum metabolites in pigs selected for lean growth efficiency

Expression of HMGR and corresponding cholesterol content in tissues of two pig breeds

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