Heritability of tic disorders: a twin-family study

Zilhão, Nuno R.; Olthof, M C; Smit, Dirk J.A.; Cath, Daniëlle C.; Ligthart, Lannie; Mathews, Carol A.; Delucchi, Kevin; Boomsma, Dorret I.; Dolan, Conor V.

doi:10.1017/s0033291716002981

Cited by 34 publications

(26 citation statements)

References 66 publications

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“…There were fewer studies on the prevalence of TS in adults. The prevalence of TS in adults was estimated between 0.05% and 0.1% [ 19 , 20 ]. In general, tic disorders are less common in adults than children, which is consistent with partial or complete remission of tic symptoms during and after adolescence.…”

Section: Introduction and Genetic Epidemiology Of Tourette’s Syndrmentioning

confidence: 99%

Progress in Genetic Studies of Tourette’s Syndrome

Zheng

et al. 2017

Brain Sciences

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Tourette’s Syndrome (TS) is a complex disorder characterized by repetitive, sudden, and involuntary movements or vocalizations, called tics. Tics usually appear in childhood, and their severity varies over time. In addition to frequent tics, people with TS are at risk for associated problems including attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety, depression, and problems with sleep. TS occurs in most populations and ethnic groups worldwide, and it is more common in males than in females. Previous family and twin studies have shown that the majority of cases of TS are inherited. TS was previously thought to have an autosomal dominant pattern of inheritance. However, several decades of research have shown that this is unlikely the case. Instead TS most likely results from a variety of genetic and environmental factors, not changes in a single gene. In the past decade, there has been a rapid development of innovative genetic technologies and methodologies, as well as significant progresses in genetic studies of psychiatric disorders. In this review, we will briefly summarize previous genetic epidemiological studies of TS and related disorders. We will also review previous genetic studies based on genome-wide linkage analyses and candidate gene association studies to comment on problems of previous methodological and strategic issues. Our main purpose for this review will be to summarize the new genetic discoveries of TS based on novel genetic methods and strategies, such as genome-wide association studies (GWASs), whole exome sequencing (WES) and whole genome sequencing (WGS). We will also compare the new genetic discoveries of TS with other major psychiatric disorders in order to understand the current status of TS genetics and its relationship with other psychiatric disorders.

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Section: Introduction and Genetic Epidemiology Of Tourette’s Syndrmentioning

confidence: 99%

Progress in Genetic Studies of Tourette’s Syndrome

Zheng

et al. 2017

Brain Sciences

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“…From these categories, we derived a dichotomous variable on absence or presence of a probable tic disorder diagnosischronic tic disorder, transient tic disorder or TS, as referenced by the Tourette Syndrome Classification Study Group (1993). An extensive genetic analysis on the heritability of tic disorders has been performed (Zilhão et al, 2015). Since smoking is known to have an effect on DNA methylation (Lee & Pausova, 2013), we controlled for smoking status in Have you ever suffered from these tics for more than a year at a time?…”

Section: Phenotypementioning

confidence: 99%

Epigenome-Wide Association Study of Tic Disorders

Zilhão

Padmanabhuni

Pagliaroli³

et al. 2015

Twin Res Hum Genet

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Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-report version of the Yale Global Tic Severity Scale Abbreviated version (YGTSS-ABBR), included in the 8th wave NTR data collection (2008). DNA methylation data consisted of 411,169 autosomal methylation sites assessed by the Illumina Infinium HumanMethylation450 BeadChip Kit (HM450k array). Phenotype and DNA methylation data were available in 1,678 subjects (mean age = 41.5). No probes reached genome-wide significance (p < 1.2 × 10−7). The strongest associated probe was cg15583738, located in an intergenic region on chromosome 8 (p = 1.98 × 10−6). Several of the top ranking probes (p < 1 × 10−4) were in or nearby genes previously associated with neurological disorders (e.g., GABBRI, BLM, and ADAM10), warranting their further investigation in relation to tic disorders. The top significantly enriched gene ontology (GO) terms among higher ranking methylation sites included anatomical structure morphogenesis (GO:0009653, p = 4.6 × 10−15) developmental process (GO:0032502, p = 2.96 × 10−12), and cellular developmental process (GO:0048869, p = 1.96 × 10−12). Overall, these results provide a first insight into the epigenetic mechanisms of tic disorders. This first study assesses the role of DNA methylation in tic disorders, and it lays the foundations for future work aiming to unravel the biological mechanisms underlying the architecture of this disorder.

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“…Twins, candidate genes, and similar studies have indicated important findings about the obvious genetic susceptibility of TS. 3 Although great progress has been made in studies of to explain the etiopathogenesis of TS, including genetic, neurodevelopmental, neurotransmitter, and neuroimmunological hypotheses, the clear development of TS is poorly unknown.…”

Section: Introductionmentioning

confidence: 99%

<p>Family-Based Analysis Combined with Case–Controls Study Implicate Roles of PCNT in Tourette Syndrome</p>

Liu

Guo

Liu

et al. 2020

NDT

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Tourette syndrome (TS) is a childhood-onset neuro-developmental disorder and the genetic factors play an important role in its etiology. As pericentrin (PCNT) binds to disruption-in-schizophrenia 1 (DISC1) and is a risk factor for many mental illnesses, we aimed to investigate the effect of PCNT on TS in the Chinese Han population. Methods: Five tag single nucleotide polymorphisms (SNPs) (rs17371795, rs2839227, rs2839228, rs6518291 and rs9983522) in PCNT were screened in 407 TS nuclear family trios and 506 healthy persons by the TaqMan assays real-time. A common casecontrol study was designed to recognize differences in the genetic distributions. Additionally, we conducted a family based association study including transmission disequilibrium test, haplotype relative risk, and haplotype-based haplotype relative risk for these SNPs. Results: The allele frequencies revealed a significant difference of rs17371795, rs2839227 and rs2839228 between TS patients and controls

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Heritability of tic disorders: a twin-family study

Cited by 34 publications

References 66 publications

Progress in Genetic Studies of Tourette’s Syndrome

Progress in Genetic Studies of Tourette’s Syndrome

Epigenome-Wide Association Study of Tic Disorders

<p>Family-Based Analysis Combined with Case–Controls Study Implicate Roles of PCNT in Tourette Syndrome</p>

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