2004
DOI: 10.1128/jvi.78.3.1063-1068.2004
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Herpes Simplex Virus Virion Host Shutoff Protein: Immune Evasion Mediated by a Viral RNase?

Abstract: Herpes simplex virus type 1 (HSV-1) is the prototypical member of the Herpesviridae, a large family of enveloped DNA viruses that infect diverse metazoans. It is also the defining example of the Alphaherpesvirinae, the neurotropic subfamily of herpesviruses. Like all herpesviruses, HSV displays both lytic and latent modes of interaction with its natural human host. Primary infection of epithelial cells produces the lytic response-virus replication followed by cell death. Progeny virus particles then infect adj… Show more

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Cited by 213 publications
(187 citation statements)
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“…Recently, the activity of this viral RNase was discussed as another mechanism for HSV-1 to evade the host's immune response (Smiley, 2004). To exclude the possibility that degradation of essential cellular mRNAs was the reason for the migration block, we performed additional experiments using a Dvhs mutant virus (Lilley et al, 2001).…”
Section: Resultsmentioning
confidence: 99%
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“…Recently, the activity of this viral RNase was discussed as another mechanism for HSV-1 to evade the host's immune response (Smiley, 2004). To exclude the possibility that degradation of essential cellular mRNAs was the reason for the migration block, we performed additional experiments using a Dvhs mutant virus (Lilley et al, 2001).…”
Section: Resultsmentioning
confidence: 99%
“…When this viral gene was deleted, the reduction of CD83 surface expression in infected mature DCs was almost abolished and the ability to become activated following HSV infection was retained. Furthermore, vhs has been characterized as a viral RNase, involved in the degradation of essential cellular mRNAs (Everly et al, 2002;Oroskar & Read, 1989), and has been suggested as an essential mediator of immune evasion (Smiley, 2004). Therefore, we wanted to obtain an insight into whether the RNase activity of vhs was responsible for the observed downregulation of CCR7 and CXCR4 mRNA levels.…”
Section: Discussionmentioning
confidence: 99%
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“…During productive infection, copies of vhs protein enter the cell as components of the virion tegument and shut off host protein synthesis by mediating the degradation of preexisting and newly transcribed mRNAs during the first few hours after infection (1-3) (reviewed in ref. 4). The hypothesis that vhs is an endoribonuclease proposed by several investigators (5)(6)(7)(8)(9) was recently unambiguously demonstrated with purified protein (10).…”
mentioning
confidence: 99%