Herpesviral infection as an etiological factor of acute idiopathic optic neuritis

Поваляева, Д А; Egorov, V.V.; Smoliakova, G.P.; Danilova, L.P.; Emanova, L.P.; Zhajvoronok, N.S.

doi:10.17116/oftalma20191350214

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…An analysis of the literature data points to the huge role of the herpesvirus family in the development of human infections common in nature [2,4,9,10,12].…”

Section: Resultsmentioning

confidence: 99%

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Dynamics of cellular immunity indicators in the complex treatment of acute optic neuritis

et al. 2023

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An increase in the incidence of optic neuritis among the working-age population, as well as an unpromising prognosis for vision due to the development of optic nerve atrophy, determines the high social significance of this problem. The aim of the work is to analyze the effect of Imunofan at the parameters of cellular immunity and clinical symptoms of the disease in the complex treatment of optic neuritis associated with herpes virus infection. The study involved 37 people (37 eyes) with acute optic neuritis associated with herpes infection. The treatment regimen included the appointment of a dexamethasone solution according to a decreasing scheme, a 1% solution of the drug Emoxipin 0.5 mL and a 12.5% solution of the drug Dicynone 0.5 mL through an irrigation system implanted in the retrobulbar space, in combination with the neuroprotection drugs (Pikamilon and Semax) for 10 days. All patients were divided into 2 groups. The main group consisted of 20 patients who received Imunofan to the treatment regimen in addition. The comparison group included 17 patients who were treated only according to the method described above. The course of treatment lasted 10 days. The analysis of the data showed a more significant positive dynamics of cellular immunity parameters in those who received immunotherapy. Our studies showed the effectiveness of this drug in the complex treatment of optic neuritis associated with herpes infection, what is confirmed by the acceleration of inflammation relief, a more significant increase in visual functions of patients treated with Imunofan, and a lower percentage of optic nerve atrophy. In this group of patients, changes in the parameters of the cellular link of immunity occurred earlier and remained stable throughout the entire period of observation. According to our data, an intergroup assessment of the immunoregulatory index showed its faster increase in patients of the comparison group who received Imunofan, and reached normal values already 6 months after treatment. The clinical effectiveness of Imunofan in the complex therapy of optic neuritis associated with herpes infection was characterized by a reduction in the period of relief of signs of inflammation in the optic nerve by 2 times or more, by an increase in the maximum corrected visual acuity by 4.5 times, and by a decrease in the incidence of recurrence of optic neuritis by 2 times over a 12 months observation period.

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“…An analysis of the literature data points to the huge role of the herpesvirus family in the development of human infections common in nature [2,4,9,10,12].…”

Section: Resultsmentioning

confidence: 99%

“…In connection with the immune imbalance, the possible formation of resistance to antiviral chemotherapy, most authors adhere to the principles of complex treatment for ophthalmic herpes and the appointment of etiotropic chemotherapy and immunocorrective therapy [4,8,9].…”

Section: лечение острого оптического невритаmentioning

confidence: 99%

Dynamics of cellular immunity indicators in the complex treatment of acute optic neuritis

et al. 2023

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“…Although optic neuritis has been associated with a vast array of infectious diseases (e.g., varicella zoster virus, influenza virus, herpes simplex virus, Epstein–Barr Virus, cytomegalovirus, West Nile virus, HIV, syphilis, tuberculosis, Lyme disease, Bartonella, and Mycoplasma pneumonia) (1–7), to the best of our knowledge, this is the first case in the English language ophthalmic literature of optic neuritis due to HFMD in an adult.…”

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confidence: 96%

Postinfectious Optic Neuritis After Hand–Foot–Mouth Disease

Barrett¹,

Bhat²,

Bindiganavile³

et al. 2021

Journal of Neuro-Ophthalmology

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A 33-year-old man presented with acute painless loss of vision in his right eye after hand-foot-mouth disease (HFMD). Examination confirmed a right optic neuropathy. Neuroimaging and routine evaluations for alternative causes for an optic neuropathy were negative. He was treated with high dose corticosteroids and made an almost complete visual recovery. Postinfectious optic neuritis has been reported after a vast array of infections including: varicella zoster virus, influenza virus, herpes simplex virus, Epstein-Barr Virus, Lyme disease, and many others. Although Coxsackie virus infections are a known cause of HFMD and have been reported to cause maculopathy, to the best of our knowledge, this is the first reported case of optic neuritis after HFMD in the English language ophthalmic literature.

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Two Zn(II)-based coordination polymers: luminescent property and protective activity on optic neuritis by regulating MAPK-AKT signaling pathway

Gao

Liu

2020

Monatsh Chem

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Herpesviral infection as an etiological factor of acute idiopathic optic neuritis

Cited by 5 publications

References 4 publications

Dynamics of cellular immunity indicators in the complex treatment of acute optic neuritis

Dynamics of cellular immunity indicators in the complex treatment of acute optic neuritis

Postinfectious Optic Neuritis After Hand–Foot–Mouth Disease

Two Zn(II)-based coordination polymers: luminescent property and protective activity on optic neuritis by regulating MAPK-AKT signaling pathway

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