Herpesvirus cyprini: Thermal Effects on Pathogenicity and Oncogenicity.

Sano, Natsumi; Moriwake, M.; Sano, Tokuo

doi:10.3147/jsfp.28.171

Cited by 36 publications

(23 citation statements)

References 8 publications

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“…For instance, latent CyHV-1 persists in carp that survive infection (41), and AngHV-1 persists in surviving infected eels (38,47). In these cases, the viral genome was found in cranial nerve cells and spinal nerves by using in situ hybridization (31,41,42). It would be interesting to determine whether the pathogenic and attenuated CNGV and CyHV-2 also persist in nerves of survivors.…”

Section: Latencymentioning

confidence: 99%

Characterization of a Novel Virus Causing a Lethal Disease in Carp and Koi

Ilouze¹,

Dishon²,

Kotler³

2006

Microbiol Mol Biol Rev

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SUMMARY Since 1998 a lethal disease of carp and ornamental koi (Cyprinus carpio) has afflicted fisheries in North America, Europe, and Asia, causing severe economic losses to the fish farming industry. This review summarizes the isolation and identification of the disease-causing agent and describes the currently known molecular characteristics of this newly isolated virus, distinguishing it from other known large DNA viruses. In addition, we summarize the clinical and histopathological manifestations of the disease. Providing information on the immune response to this virus and evaluating the available means of diagnosis and protection should help to reduce the damage induced by this disease. This review does not discuss the economic aspects of the disease or the debate on whether the disease should be registered; both of these issues were recently reviewed in detail (O. L. M. Haenen, K. Way, S. M. Bergmann, and E. Ariel, Bull. Eur. Assoc. Fish Pathol. 24:293-307, 2004; D. Pokorova, T. Vesely, V. Piackova, S. Reschova, and J. Hulova, Vet. Med. Czech. 50:139-147, 2005).

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Section: Latencymentioning

confidence: 99%

Characterization of a Novel Virus Causing a Lethal Disease in Carp and Koi

Ilouze¹,

Dishon²,

Kotler³

2006

Microbiol Mol Biol Rev

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Section: Discussionmentioning

confidence: 99%

“…Unfortunately, no water-quality data are available for that period. The role of rising water temperature to papilloma outbreak is not likely, since Sano et al (1993) found a regression of papillomatosis induced by Herpesvirus cyprini in rising water temperature in fancy carp Cyprinus carpio.Roach males produce breeding tubercles during spawning. Breeding tubercles are keratinised epidermal nodules, which are found commonly in many fish taxa, more often in males (see review in Wiley & Collette 1970).…”

mentioning

confidence: 99%

Epizootic cutaneous papillomatosis in roach Rutilus rutilus: sex and size dependence, seasonal occurrence and between-population differences

Kortet¹,

Vainikka²,

Taskinen³

2002

Dis. Aquat. Org.

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Epidemiology of epidermal papillomatosis in roach Rutilus rutilus was studied in 11 roach populations in Finland in 1999 and 2000 during the spawning period. In addition, the seasonal pattern of the disease was described in 1 population. Papilloma tumours were observed on the skin and fins of roach in 8 populations out of 11. Prevalence of papillomatosis varied from 0 to 62%, being higher in populations subject to industrial or sewage effluents. Males and large fish had higher prevalence of papilloma tumours. The disease outbreak peaked during the spawning period and signs of recovered skin on fish were observed later during the year. The gender dependence in the disease prevalence found in the study may indicate differences in stress and immunocompetence between roach males and females during the spawning period.KEY WORDS: Spawning papillomatosis · Roach · Tumours · Seasonality · Gender dependence · Pollution Resale or republication not permitted without written consent of the publisherDis Aquat Org 52: [185][186][187][188][189][190] 2002 gested immunomodulative role of androgens (Folstad & Karter 1992, Braude et al. 1999) and intensive spawning of roach (Wedekind 1996), we expected males to have higher prevalences and intensities of papilloma, especially during spawning. We studied the prevalence of the disease during spawning from separated roach populations in randomly chosen polluted and non-polluted waters to monitor the possible environmental aspects of the phenomenon (Möller & Anders 1986). In one of the populations, we also studied the seasonal pattern of the disease. MATERIALS AND METHODSA total of 1683 adult roach specimens (mean length ± SD; 159.1 ± 29 mm) were collected using netting, and studied during the spawning period from 6 populations between April and May 1999, and from 11 populations in 2000. Sampled populations, exact sample sizes and dates are given in Table 1. The sampled populations were classified into 2 groups by their pollution backround (e.g. Paasivirta et al. 1986, Granberg 1987: (1) human-impact waters including industrial and/or sewage effluents, and (2) non-human-impact waters (see Table 1). The study populations were from separate areas, and were within 100 km distance from the city of Jyväskylä (62°14' N, 25°46' E, central Finland), except for Lake Viitajärvi (64°38'N, 24°26'E, the Baltic Sea population, northern Finland) and River Alajoki (60°90' N, 28°12' E, discharging to the Baltic Sea, south-east Finland).The seasonal occurrence of the disease was studied from 8 additional samples (n = 434) taken between February and November 1999 from Lake Jyväsjärvi. This lake was chosen for the seasonal study, because earlier observations indicated that disease occurrence was most severe in this lake. Exact monthly sample sizes and dates for Lake Jyväsjärvi are given in Fig. 1. Fish were caught by angling and netting.Fish were killed with a sharp blow to the head immediately after catching. We measured the fork length of the fish and determined the sex by examining the gon...

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“…Such papillomas coalesce as they spread over the surface of carp as white plaques, and develop focal exophytic masses (Wildgoose, 1992). These papillomas are caused by Herpesvirus cyprini (also cyprinid herpesvirus 1, CHV) (Sano et al, 1991), regress in warm summers or when held above 20°C (Sano et al, 1993b), and persist below 15°C (Sano et al, 1993a). Viruses have also been associated with papillary epidermal plaques in other fish species (Wolf, 1988), such as walleye, in which a retroviral etiology is suspected (LaPierre et al, 1998).…”

Section: Beckwith Et Almentioning

confidence: 99%

Ethylnitrosourea Induces Neoplasia in Zebrafish (Danio rerio)

Beckwith

Moore

Tsao-Wu

et al. 2000

Laboratory Investigation

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SUMMARY:The zebrafish (Danio rerio) has been successfully used to discover hundreds of genes involved in development and organogenesis. To address the potential of zebrafish as a cancer model, it is important to determine the susceptibility of zebrafish to tumors. Germ line mutations are most commonly induced for zebrafish mutant screens by exposing adult male zebrafish to the alkylating agent, ethylnitrosourea (ENU). To determine whether ENU induces tumors, we compared the incidence of tumors in ENU-treated fish with untreated controls. Interestingly, 18 of 18 (100%) fish mutagenized with either 2.5 or 3.0 mM ENU developed epidermal papillomas, which numbered 1 to 22 per fish, within 1 year of treatment. The induced epidermal lesions included epidermal hyperplasia, flat papillomas (0.2 to 1.2 mm), and pedunculated papillomas (1.2 to 8 mm in greatest dimension), but no skin cancers. Angiogenesis was evident in papillomas larger than approximately 1 mm. All but two papillomas contained the three cell types (keratinocytes, club, and mucous cells) of normal zebrafish epidermis; histologic variants lacked either club cells or mucous cells. Two cavernous hemangiomas and a single malignant peripheral nerve sheath tumor were also found in the treated fish. None of five untreated controls developed tumors. These studies establish the feasibility of the zebrafish as an experimental model for the study of skin tumors. (Lab Invest 2000, 80:379-385).

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Herpesvirus cyprini: Thermal Effects on Pathogenicity and Oncogenicity.

Cited by 36 publications

References 8 publications

Characterization of a Novel Virus Causing a Lethal Disease in Carp and Koi

Characterization of a Novel Virus Causing a Lethal Disease in Carp and Koi

Epizootic cutaneous papillomatosis in roach Rutilus rutilus: sex and size dependence, seasonal occurrence and between-population differences

Ethylnitrosourea Induces Neoplasia in Zebrafish (Danio rerio)

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