Heschl's Gyrus, Posterior Superior Temporal Gyrus, and Mid-Ventrolateral Prefrontal Cortex Have Different Roles in the Detection of Acoustic Changes

Schönwiesner, Marc; Novitski, Nikolai; Pakarinen, Satu; Carlson, Synnöve; Tervaniemi, Mari; Näätänen, Risto

doi:10.1152/jn.01083.2006

Cited by 159 publications

(140 citation statements)

References 55 publications

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“…4). This is in contrast to functional neuroimaging data of automatic change detection in adults (57), which show increased BOLD responses in the auditory cortex in response to acoustic changes.…”

Section: Discussioncontrasting

confidence: 99%

Functional specializations for music processing in the human newborn brain

Perani

Saccuman

Scifo

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

294

175

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In adults, specific neural systems with right-hemispheric weighting are necessary to process pitch, melody, and harmony as well as structure and meaning emerging from musical sequences. It is not known to what extent the specialization of these systems results from longterm exposure to music or from neurobiological constraints. One way to address this question is to examine how these systems function at birth, when auditory experience is minimal. We used functional MRI to measure brain activity in 1-to 3-day-old newborns while they heard excerpts of Western tonal music and altered versions of the same excerpts. Altered versions either included changes of the tonal key or were permanently dissonant. Music evoked predominantly right-hemispheric activations in primary and higher order auditory cortex. During presentation of the altered excerpts, hemodynamic responses were significantly reduced in the right auditory cortex, and activations emerged in the left inferior frontal cortex and limbic structures. These results demonstrate that the infant brain shows a hemispheric specialization in processing music as early as the first postnatal hours. Results also indicate that the neural architecture underlying music processing in newborns is sensitive to changes in tonal key as well as to differences in consonance and dissonance.auditory cortex | functional MRI | neonates | emotion

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Section: Discussioncontrasting

confidence: 99%

Functional specializations for music processing in the human newborn brain

Perani

Saccuman

Scifo

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

294

175

View full text Add to dashboard Cite

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“…b Mean cortical thickness values within the left insula cluster for both groups at each session. Error bars represent 95% confidence intervals (Color figure online) auditory processing (Mothes-Lasch, Becker, Miltner, & Straube 2016;Schönwiesner et al 2007;Vossel, Weidner, & Fink 2011). These changes in functional connectivity were greatest for those who showed the largest increases in dispositional mindfulness.…”

Section: Discussionmentioning

confidence: 99%

“…The posterior insula increased in rs-FC with both the left MTG/STG and right vlPFC. These structurally connected regions have been repeatedly implicated in auditory processing and are thought to comprise a network involved in the detection of novel auditory information (Petrides & Pandya 2002;Plakke & Romanski 2014;Rauschecker & Scott 2009;Schönwiesner et al 2007;Buse & Roessner 2016;Kiehl et al 2001).…”

Section: Resting-state Functional Connectivity Changes In the Posterimentioning

confidence: 99%

“…The middle temporal gyrus has been implicated in semantic processing, likely bridging the auditory representations in the STG to conceptual information distributed throughout the cortex (Hickok & Poeppel 2004;Visser, Jefferies, Embleton, & Lambon Ralph 2012). The right vlPFC is involved in phonological processing and allocating attention toward acoustic changes (Burton 2009;Schönwiesner et al 2007). …”

Section: Resting-state Functional Connectivity Changes In the Posterimentioning

confidence: 99%

“…The posterior insula is a region of particular interest to the present research because of its implication in auditory and interoceptive processing by both structural and functional neuroimaging research (Bamiou, Musiek, & Luxon 2003;Remedios, Logothetis, & Kayser 2009;Flynn 1999) and due to the previously demonstrated effect of mindfulness training on the activation and functional connectivity of this region (Kilpatrick et al 2011;Farb et al 2012;Kirk, Gu, Harvey, Fonagy, & Montague 2014). Changes in cortical thickness of the posterior insula may lead to changes in auditory processing, and the posterior insula may interact with other regions implicated in auditory processing, such as the left middle/superior temporal gyrus (MTG/STG) and right ventrolateral prefrontal cortex (vlPFC) in a network involved in the detection of novel auditory information (Petrides & Pandya 2002;Plakke & Romanski 2014;Rauschecker & Scott 2009;Schönwiesner et al 2007;Buse & Roessner 2016;Kiehl, Laurens, Duty, Forster, & Liddle 2001). Various forms of meditation are associated with activity in the insula as well as somatomotor cortex, the primary cortical site of tactile information processing (Fox et al 2016).…”

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confidence: 99%

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An Integrated Assessment of Changes in Brain Structure and Function of the Insula Resulting from an Intensive Mindfulness-Based Intervention

Mooneyham

Mrazek

et al. 2017

J Cogn Enhanc

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Mindfulness training is thought to alter both brain function and structure, yet these effects are almost always investigated and reported independently. In the present study, we combine these two approaches to provide a more complete description of the effects of a 6-week mindfulness-based health and wellness intervention. Region-of-interest analysis of brain structure revealed a significant increase in cortical thickness within the left-hemisphere posterior insula, a region that plays a role in auditory perception and interoception. We then examined changes in the resting-state functional connectivity (rs-FC) of this insula cluster and found two regions with which it displayed increased functional connectivity: one in the right-hemisphere ventrolateral prefrontal cortex (vlPFC) and another spanning parts of the left-hemisphere middle and superior temporal gyri (MTG/STG). Individuals with the greatest improvements in dispositional mindfulness showed the greatest increases in insular thickness as well as greater increases in rs-FC of the posterior insula with vlPFC and MTG/STG. The insula, vlPFC, and MTG/STG comprise a structurally connected network involved in, respectively, early auditory perception, the allocation of attention to changes in sounds, and the detailed analysis of fluctuations in sounds. Accordingly, these findings suggest a mechanistic account of the alterations in brain structure and function that underlie changes in auditory processing following a mindfulnessbased intervention.

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Stereological study of pyramidal neurons in the human superior temporal gyrus from childhood to adulthood

Barger

Sheley

Schumann

2015

J of Comparative Neurology

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The association cortex of the superior temporal gyrus (STG) is implicated in complex social and linguistic functions. As such, reliable methods for quantifying cellular variation in this region could greatly benefit researchers interested in addressing the cellular correlates of typical and atypical function associated with these critical cognitive abilities. To facilitate this task, we first present a general set of cytoarchitectonic criteria targeted specifically toward stereological analyses of thick, Nissl stained sections for the homotypical cortex of the STG, referred to, here, as BA22/TA. Secondly, we use the optical fractionator to estimate pyramidal neuron number and the nucleator for pyramidal somal and nuclear volume to investigate the influence of age and sex on these parameters and to set a typically developing baseline for future comparisons. In 11 typically developing cases aged 4-48 years, the most distinguishing features of BA22/TA were the presence of distinct granular layers, a prominent, jagged layer IIIc, and a distinctly staining VIa. The average number of neurons was 91 ± 15 million, volume of pyramidal soma, 1,512 μm3, and nuclear volume, 348 μm3. We found no correlation with age and neuron number. In contrast, pyramidal somal and nuclear volume were both negatively correlated and linearly associated with age in regression analyses. We found no significant sex differences. Overall, the data support the idea that postnatal neuron numbers are relatively stable through development but also suggest that neuronal volume may be subject to important developmental variation. Both measures are critical variables in the study of developmental neuropathology.

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Heschl's Gyrus, Posterior Superior Temporal Gyrus, and Mid-Ventrolateral Prefrontal Cortex Have Different Roles in the Detection of Acoustic Changes

Cited by 159 publications

References 55 publications

Functional specializations for music processing in the human newborn brain

Functional specializations for music processing in the human newborn brain

An Integrated Assessment of Changes in Brain Structure and Function of the Insula Resulting from an Intensive Mindfulness-Based Intervention

Stereological study of pyramidal neurons in the human superior temporal gyrus from childhood to adulthood

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