Hesperidin a flavanoglycone protects against γ-irradiation induced hepatocellular damage and oxidative stress in Sprague–Dawley rats

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

“…It is also involved in the maintenance of exogenous antioxidants. The notable decline in the key cellular non-enzymatic antioxidant defense system considerably increases the susceptibility to oxidative stress (Rajadurai et al, 2009;Pradeep et al, 2008;Amália et al, 2007).…”

“…A number of researchers have evaluated the antioxidant activity and radical scavenging properties of flavonoids, including hesperidin (Tirkey et al, 2005;Jovanovic et al, 1994;Suarez et al, 1998), naringin (Mahmoud et al, 2012), and quercetin (Rajadurai et al, 2009;Pradeep et al, 2008), using a variety of assay systems. Sahu et al (2013) indicated that oral hesperidin administration significantly increased serum levels of GSH, GST, GR and GSH-Px as well as decreased the expression of lipid peroxidation in rats.…”

Hesperidin promotes cyclobutane pyrimidine dimer repair in UVB-exposed mice epidermis

“…HPD has a strong antioxidant activity toward ROS, including hydroxyl 711 radical (OHÁ), superoxide anions (O 2 Á) and peroxynitrite (ONOO -) in UVB-irradiated HaCaT cells and rat tissues [6,17,18]. The results suggest that HPD shows anti-oxidative properties and probably reduces the UVB-elicited oxidative cellular damage.…”

“…Such a filter effect may not contribute to the observed HPD-mediated protection against UVB-elicited CPDs production as, in our study, the amount of CPDs was not reduced in HPD-treated mice epidermis when compared with that of untreated mice at 0 h after UVB irradiation. Anti-oxidant properties of HPD reported earlier in rat tissue [6,17,18] suggest that suppression of oxidative stress by HPD could be one of the possible mechanisms that resulted in the activation of repair enzymes. Previous studies have shown that topical and oral antioxidant decreases acute sunburn response.…”

Radioprotective activity of Gentiana lutea extract and mangiferin

“…It was also shown that orally taken radioprotectors exert considerable radioprotective capacity tested on mice even after metabolic digestion (Sandhya et al, 2006;Goel et al, 2004;Singh et al, 1995;Pradeep et al, 2008). Oral administration of hesperidin showed protection against irradiation-induced hepatocellular damage and oxidative stress in rats, probably by exerting a protective effect against hepatocellular necrosis via its free radical scavenging and membrane stabilizing ability (Pradeep et al, 2008). Although intraperitoneal administration of herbal preparations has shown their radioprotective potential, frequent i.p.…”