Hesperidin alleviates zinc oxide nanoparticle induced hepatotoxicity and oxidative stress

Abstract

BackgroundNanoparticles are widely utilized in many products such as cosmetics and sunscreens. The present study was undertaken to evaluate the effect of hesperidin (HSP) on nano zinc oxide particles (nZnO) induced oxidative stress in rat livers.MethodsRats were randomly divided into 4 groups of 6 rats each and exposed to single administration of nZnO intraperitoneally (600 mg/kg bwt) and HSP (100 mg/kg bwt) by gavage. Group I served as the control; group II was given nZnO only; groups III received HSP only and group IV received nZnO 1 h after pretreatment with HSP for 7 days.ResultsCompared to the controls, nZnO administration enhanced alanine aminotransferase (AST) and aspartate aminotransferase (ALT) levels (p < 0.05) with reduction in the levels of glutathione (GSH), catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) and increase in levels of malondialdehyde (MDA) while HSP attenuated nZnO-induced hepatotoxicity for above mentioned parameters.ConclusionsThe induced toxicity in the liver was corrected by pretreatment with HSP. The findings of this study suggest that HSP pretreatment can potentially be used to prevent nZnO-induced biochemical alterations toxicity. Further, protection by HSP on biochemical results was confirmed by histopathological changes. The present study suggests that HSP can protect against nZnO-induced oxidative damage in the rat livers.

Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats

“…The NOAEL index for ZnONPs in rats is around 125 mg/kg [ 46 ]. In our study, we evaluated two doses below this range, 10 and 100 mg/kg because several reports argue that higher doses (250–2000 mg/kg) generate histological alterations in the liver [ 43 , 47 ]. Such alterations are directly related to the increase in ALT (Alanine aminotransferase) and AST (Aspartate aminotransferase) levels in studies carried out in mice [ 44 , 48 ].…”

Effect of hesperidin on fluoride‐induced neurobehavioral and biochemical changes in rats

“…In some recent preclinical investigations, the neuroprotective effect of hesperidin has been established in lipopolysaccharide‐induced neuroinflammation (via modulating Toll‐like receptor 4 [TLR4]/nuclear factor‐κB [NF‐κB] signaling) and Aβ‐induced neurodegeneration (by regulating Nrf2/TLR4/NF‐κB signaling). [ 12,13 ] Hesperidin has also been reported to alleviate metal‐associated oxidative stress in brain, [ 14 ] which includes cadmium‐induced brain oxidative stress, [ 15 ] zinc‐induced oxidative stress, [ 16 ] and iron‐induced oxidative damage and dopamine depletion. [ 17 ] Though hesperidin has been reported to mitigate metal‐induced neurotoxicity, little is known about the effect of hesperidin against fluoride‐induced neurotoxicity.…”

DNA damage and genetic aberration induced via different sized silver nanoparticles: Therapeutic approaches of Casimiroa edulis and Glycosmis pentaphylla leaves extracts

“…Rutin can inhibit some carcinogenic and precancerous conditions, prevent atherogenesis, and reduce the cytotoxicity of oxidized LDL cholesterol. This is due to its antioxidant, antiallergic, anti‐inflammatory, anti‐angiogenic, and antiviral assets (Ansar, Abudawood, Alaraj, & Hamed, 2018; Sherif, Hussein, Eid, & Abas, 2019). Cinnamic acids, especially hydroxyl–cinnamic acids, have the role of basic precursors in the biosynthesis of various plant phenols (Hollman, 2001).…”