Hesperidin Ameliorates Anxiety-Depressive-Like Behavior in 6-OHDA Model of Parkinson’s Disease by Regulating Striatal Cytokine and Neurotrophic Factors Levels and Dopaminergic Innervation Loss in the Striatum of Mice

Antunes, Michelle S.; Souza, Leandro Cattelan; Ladd, Fernando Vagner Lobo; Ladd, Aliny Antunes Barbosa Lobo; Moreira, Amanda Lopez; Bortolotto, Vandreza Cardoso; Poetini, Márcia Rósula; Araújo, Stífani Machado; Prigol, Marina; Nogueira, Cristina Wayne; Boeira, Silvana Peterini

doi:10.1007/s12035-020-01940-3

Cited by 46 publications

(19 citation statements)

References 61 publications

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“…The nucleus accumbens is populated only by medium-sized CR+ interneurons, which are distributed equally among the core and shell compartments and whose density is unaltered after dopamine denervation. Our results provide the rst evidence that the medium-sized striatal interneurons expressing low level of CR are speci cally targeted by dopamine denervation, while the small and intensely immunoreactive CR+ cells remain unaffected.These ndings suggest that high expression of the calcium binding protein CR might protect striatal interneurons against an increase in intracellular calcium level that is believed to arise from altered glutamate corticostriatal transmission in Parkinson's disease.in ammatory cytokines and reduced concentrations of neurotrophic factors have previously been reported in the 6-OHDA-lesioned mice (Antunes et al 2020).…”

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confidence: 72%

The density of calretinin striatal interneurons is decreased in 6-OHDA-lesioned mice

et al. 2021

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Interneurons play a signi cant role in the functional organization of the striatum and some of them display marked plastic changes in dopamine-depleted conditions. Here, we applied immunohistochemistry on brain sections from 6-hydroxydopamine (6-OHDA) mouse model of Parkinson's disease and sham animals to characterize the regional distribution and the morphological and neurochemical changes of striatal interneurons expressing the calcium binding protein calretinin (CR). Two morphological subtypes of calretinin-immunostained (CR+) interneurons referred respectively as small and medium-sized CR+ interneurons were detected in 6-OHDA and sham-lesioned animals. The small cells (9-12 µm) prevail in the anterior and dorsal striatal regions; they stain intensely for CR and display a single slightly varicose and moderately arborized process. The medium-sized CR+ interneurons (15-20 µm) are slightly more numerous than the small CR+ cells and rather uniformly distributed within the striatum; they stain weakly for CR and display 2-3 long, slightly varicose and poorly branched dendrites. The density of medium CR+ interneurons is signi cantly decreased in the dopamine-depleted striatum (158 ± 15 neurons/mm 3 ), when compared to sham animals (370 ± 41 neurons/mm 3 ), whereas that of the small-sized CR+ interneurons is unchanged (174 ± 46 neurons/mm 3 in 6-OHDA-lesioned striatum and 164 ± 22 neurons/mm 3 in sham-lesioned striatum). The nucleus accumbens is populated only by medium-sized CR+ interneurons, which are distributed equally among the core and shell compartments and whose density is unaltered after dopamine denervation. Our results provide the rst evidence that the medium-sized striatal interneurons expressing low level of CR are speci cally targeted by dopamine denervation, while the small and intensely immunoreactive CR+ cells remain unaffected.These ndings suggest that high expression of the calcium binding protein CR might protect striatal interneurons against an increase in intracellular calcium level that is believed to arise from altered glutamate corticostriatal transmission in Parkinson's disease.in ammatory cytokines and reduced concentrations of neurotrophic factors have previously been reported in the 6-OHDA-lesioned mice (Antunes et al. 2020).

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confidence: 72%

The density of calretinin striatal interneurons is decreased in 6-OHDA-lesioned mice

et al. 2021

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“…Consumption of these parts known to be rich in flavonoids has been reported to result in anti-anxiety effect [24,25]. In addition to the anxiolytic effect, flavonoids were shown to prevent neuro-degeneration [26]. The obtained data from this research illustrated that the extract may provide an alternative treatment for neurological disorders such as anxiety and depression.…”

Section: Discussionmentioning

confidence: 60%

Potential of an aqueous extract of Lippia multiflora Moldenke (Verbenaceae) in the treatment of anxiety disorders: Possible involvement of serotoninergic transmission

Ngaibi¹,

Taïwé²,

Njapdounke³

et al. 2021

GSC Biol. and Pharm. Sci.

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Ethnopharmacological relevance: The leaves and stems of Lippia multiflora Moldenke (Verbenaceae) are used in traditional medicine to treat depression, anxiety and epilepsy. Aim of the study: The present study investigated the anxiolytic-like effects of Lippia multiflora aqueous extracts in experimental models of anxiety. Materials and methods: Elevated plus maze and open field tests were used to evaluate anxiety and exploratory behaviour. The possible mechanism of action of Lippia multiflora were investigated after pretreatment of animal with agonist and antagonist of serotonin receptors, such as: mCPP, a partial agonist at the 5-HT2C receptors; Way-100635, a selective 5-HT1A receptors antagonist; and DOI, the 5-HT2A/2C receptors agonist. The levels of monoamine neurotransmitters were evaluated in the brain. Results: In the elevated plus maze, Lippia multiflora increased the number of entries into and percentage of time in open arms, and reduced rearing, head dipping, and percentage of time in closed arms. These effects were blocked with the agonist and antagonist of serotonin receptors. In the open field, Lippia multiflora increased crossing and reduced rearing and defecation. The endogenous levels of noradrenaline, dopamine and serotonin in the brain homogenates remain comparable to that distilled water-treated animals. Conclusion: It could be concluded that Lippia multiflora aqueous extracts, used in traditional medicine in Cameroon for the treatment of depression, anxiety and epilepsy seemed to possess anxiolytic properties in mice. These effects might be mediated by serotonin receptors, but not by modulation of the levels of monoamine neurotransmitters when the extract is administered once after one hour.

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“…The ability of hesperidin to fight damage from toxic oxygen radicals and stimulate the expression of Nrf2 has been reported by various authors in other experimental models namely in hepatocarcinogenesis [96], hepatotoxicity [97], neuroinflammation and neurodegeneration [91,[98][99][100][101][102]. The protective effects of quercetin in neurodegenerative disorders and cerebrovascular diseases, demonstrated both in in vitro and in vivo studies are also largely linked to its ability to stimulate the defences against oxidative stress [103].…”

Section: Oxidative Stressmentioning

confidence: 96%

Reappraisal of Dietary Phytochemicals for Coronavirus Infection: Focus on Hesperidin and Quercetin

Bellavite¹

2021

Antioxidants - Benefits, Sources, Mechanisms of Action

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Food polyphenols constitute a large family of substances with beneficial properties in a large group of communicable and non-communicable diseases. These compounds support and improve the body’s defences against oxidative stress and are helpful in the prevention of pathologies related to metabolic syndrome. Furthermore, they exhibit anti-inflammatory, antiviral, and antimicrobial properties. This chapter draws attention to certain nutritional components such as hesperidin and quercetin, which are emerging as good candidates for a complementary beneficial effect in the case of diseases caused by viruses, including COVID-19. These nutraceuticals have a complex mechanism of action, which involves both cellular defence against oxidative stress and the modulation of inflammation, which although normally is a defence, repair and activation mechanism of the immune system, it can elude its controls and become a systemic and destructive pathology (cytokine storm, respiratory distress syndrome). Furthermore, recent in silico simulation tests suggest that both hesperidin and quercetin may interfere with SARS-CoV-2 by binding to cell receptors and the proteolytic enzymes involved in its replication. In addition to the inhibitory effects on the virus at cellular level, the two flavonoids can have indirect effects in respiratory infectious diseases as they prevent or improve metabolic and vascular comorbidities that can complicate the clinical course. This brief review focuses on biochemical and pharmacological mechanisms of action of polyphenols in the context of the revaluation of dietary approaches to the prevention and treatment of infectious diseases caused by viruses, with a special application to COVID-19.

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Hesperidin Ameliorates Anxiety-Depressive-Like Behavior in 6-OHDA Model of Parkinson’s Disease by Regulating Striatal Cytokine and Neurotrophic Factors Levels and Dopaminergic Innervation Loss in the Striatum of Mice

Cited by 46 publications

References 61 publications

The density of calretinin striatal interneurons is decreased in 6-OHDA-lesioned mice

The density of calretinin striatal interneurons is decreased in 6-OHDA-lesioned mice

Potential of an aqueous extract of Lippia multiflora Moldenke (Verbenaceae) in the treatment of anxiety disorders: Possible involvement of serotoninergic transmission

Reappraisal of Dietary Phytochemicals for Coronavirus Infection: Focus on Hesperidin and Quercetin

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