Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin

Kim, Bora; Lee, Jee Young; Lee, Ha Yeon; Nam, Ky Youb; Park, Jong Il; Lee, Su‐Min; Kim, Jin Eun; Lee, Joo Dong; Hwang, Jae Sung

doi:10.4062/biomolther.2013.032

Cited by 26 publications

(33 citation statements)

References 23 publications

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“…Equally, by sequestering metal ions or the effects on the expression of endogenous protein tissue inhibitors of metalloproteinase (TIMPs) [ 9 ], flavonoids can act protectively. Flavonoids’ skin whitening activity relates to their modulation of tyrosinase activity, through their chelating of calcium(II), in the formation of L-dopaquinone, which is a part of the melanogenesis process [ 56 ]. This ability is common to quercetin, cyanidin, and kaempferol, while their glycoside forms have not shown this capability [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Daily topical applications of HSD microemulsion have shown a significant skin whitening effect, reduction in trans-epidermal water loss, and inhibition of irritation effect after exposure to UV rays after four weeks. In their study, Kim et al [ 56 ] showed that HSD had a depigmentation effect by blocking the melanophilin, a tripartite protein complex which is a response for transport of the melanosome into the melanocytes. This was proven by melanosome aggregation tests in cells.…”

Section: Discussionmentioning

confidence: 99%

“…This was proven by melanosome aggregation tests in cells. HSD did not inhibit melanin production in melanoma cells, but reduced skin pigmentation in the reconstruction of human epidermal skin [ 56 ]. HSD may also affect polyoxygenase, cyclooxygenase, hyaluronidase, collagenase, elastase, and tyrosinase; thus, it can contribute to the reduction in modifications in the skin’s connective tissue remodeling [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

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New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

et al. 2020

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Hesperidin, a secondary orange (Citrus sinensis) metabolite, was extracted from orange bagasse. No organic solvents or additional energy consumption were used in the clean and sustainable process. Hesperidin purity was approximately 98% and had a yield of 1%. Hesperidin is a known supplement due to antioxidant, chelating, and anti-ageing properties. Herein, hesperidin application to eliminate dark eye circles, which are sensitive and thin skin regions, was studied. In addition, the proposed method for its aqueous extraction was especially important for human consumption. Further, the most effective methods for hesperidin nanonization were explored, after which the nanoemulsions were incorporated into a cream formulation that was formulated for a tropical climate. Silky cream formulations (oil in water) were tested in vitro on artificial 3D skin from cultured cells extracted from skin residues after plastic surgery. The proposed in vitro assay avoided tests of the different formulations in human volunteers and animals. It was shown that one of the nanonized hesperidin formulations was the most skin-friendly and might be used in cosmetics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

et al. 2020

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“…Hesperidin that is a major component of our CPE neither inhibit melanin production in B16F10 murine melanoma cells stimulated with α-melanocyte stimulating hormone nor affect the catalytic activity of tyrosinase. Instead, hesperidin inhibited melanosome transport in melanocytes and exerted a skin lightening effect in a pigmented reconstructed epidermis model [13].…”

Section: Subjective Efficacymentioning

confidence: 97%

Effect of Oral Intake of A Mixture Containing Natural Citrus Peel Extract, Vitamin C, and L-Cystine on Skin Brightness in Healthy Women

Kim¹,

Park²,

Hwang³

et al. 2018

JFNR

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Citrus peel extract (CPE) has several bioactivities that encompass anti-oxidation, anti-inflammation and anti-melanogenic effect. However, its usage in functional food has been difficult due to uncommon evidence in human trial. The reason of this study is to evaluate the safety and skin brightening effects of natural CPE in human subjects. To enhance its effectiveness in clinical trial, we also used both vitamin C for anti-oxidation and L-cystine for decreasing melanin biosynthesis. All subjects administered 1 test capsule (AP-BF02 including 100mg of CPE, 125mg of vitamin C, 60mg of L-cystine) or placebo for two months. We objectively measured changes in melanin index (MI), skin lightness (L*), and skin color (ITA O). The two investigators also used subjective ratings to analyze skin pigmentation. The MI values were significantly lower in test group, compared with that in placebo group from 4 weeks after. In addition, AP-BF02-intake group had significant improvement in lightness and color at the end of examine period. Consequently, oral supplementation with AP-BF02 can brighten human skin in healthy women without adverse effect.

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“…According to a recent study, Rab27a-Mlph and Mlph-Myo5a interactions are very important for melanosome transport. For example, hesperidin blocks the Rab27a-Mlph interaction and therefore causes melanosome aggregation in melanocytes [8]. Also, manassantin B causes melanosome aggregation in melanocytes by blocking the Mlph-Myo5a interaction [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Hoechunyangkyeok-San Extract on Melanogenesis

Kim¹,

Jung²,

Park³

et al. 2016

JCDSA

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Forsythia fructus has been shown to have antioxidative, anti-inflammatory, antibacterial, antiaging and whitening effects. Hoechunyangkyeok-san (Forsythia viridissima-prescription) is a traditional herbal medicine, which has been clinically used for treating febrile and inflammatory disorders. This work was carried out to investigate the skin whitening effects of Forsythia viridissima-prescription extract (a hydrolyzed extract of Hoechunyangkyeok-san: SID White HYC) on skin. The effects of SID White HYC were assessed the melanin contents in B161 melanoma cells and the pigmented equivalent with HMB45 and Fontana Masson staining in 3D skin model. Then, we examined the expression of major pigment enzymes regulating melanin synthesis and melanosome transport related proteins in B16F1 cells. SID White HYC significantly inhibited the melanin synthesis (56.7% and 30.6% inhibition at 100 μg/mL, intracellular and secreted, respectively) in B16F1 cells and 3D skin model. In addition, western blotting analysis showed that SID White HYC reduced the expression of melanin synthesis and melanosome transport related proteins in B16F1 cells. In clinical trials, the cream containing 0.05% SID White HYC showed skin depigmentation effect without any irritation. These results suggest that SID White HYC may be useful inhibition of melanogenesis and melanosome transport. Therefore, SID White HYC may have potential as a skin-whitening ingredient in cosmetics.

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Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin

Cited by 26 publications

References 23 publications

New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

Effect of Oral Intake of A Mixture Containing Natural Citrus Peel Extract, Vitamin C, and L-Cystine on Skin Brightness in Healthy Women

Effect of Hoechunyangkyeok-San Extract on Melanogenesis

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