Heteroaromatic Diazirines Are Essential Building Blocks for Material and Medicinal Chemistry

Abstract

In materials (polymer) science and medicinal chemistry, heteroaromatic derivatives play the role of the central skeleton in development of novel devices and discovery of new drugs. On the other hand, (3-trifluoromethyl)phenyldiazirine (TPD) is a crucial chemical method for understanding biological processes such as ligand–receptor, nucleic acid–protein, lipid–protein, and protein–protein interactions. In particular, use of TPD has increased in recent materials science to create novel electric and polymer devices with comparative ease and reduced costs. Therefore, a combination of heteroaromatics and (3-trifluoromethyl)diazirine is a promising option for creating better materials and elucidating the unknown mechanisms of action of bioactive heteroaromatic compounds. In this review, a comprehensive synthesis of (3-trifluoromethyl)diazirine-substituted heteroaromatics is described.

Synthesis, Biological Evaluation, and Docking Study of a New Series of Thiophene Derivatives Based on 3‐Oxobutanamidothiophene as an Anticancer Agent

“…They are remarkably effective compounds, both with respect to their diverse biological and pharmacological functions. [5,6] Many derivatives based on 2aminothiophenes were tested in mammalian carcinoma cells such as PC3 (prostate cancer), HepG2 (liver carcinoma), Hep-2 (laryngeal carcinoma), and MCF-7 (breast cancer) [7][8][9][10] (Figure 1). Furtheromore, the thiophene moiety also shows wide biological activities, such as antibacterial, [11][12][13] antioxidant, antifungal, SARS-CoV-2 main protease inhibition, [14][15][16][17] anti-inflammatory, [18] and anti-tubercular.…”

“…It has been documented to exhibit a broad spectrum of therapeutic qualities with various uses in the fields of medicinal chemistry and material science. They are remarkably effective compounds, both with respect to their diverse biological and pharmacological functions [5,6] . Many derivatives based on 2‐aminothiophenes were tested in mammalian carcinoma cells such as PC3 (prostate cancer), HepG2 (liver carcinoma), Hep‐2 (laryngeal carcinoma), and MCF‐7 (breast cancer) [7–10] (Figure 1).…”