Heteroatom doped carbon dots with nanoenzyme like properties as theranostic platforms for free radical scavenging, imaging, and chemotherapy

Dehvari, Khalilalrahman; Chiu, Sheng-Hui; Lin, Jin-Sheng; Girma, Wubshet Mekonnen; Ling, Yong‐Chien; Chang, Jia-Yaw

doi:10.1016/j.actbio.2020.07.022

Cited by 72 publications

(43 citation statements)

References 72 publications

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“…In the past decade, many strategies have been employed to scavenge excessive ROS and alleviate inflammation responses, among which emerging therapeutic approaches utilizing enzymatically active nanomaterials as antioxidants have attracted more and more attention ( Thakur et al, 2019 ; Shah et al, 2020 ; Wang L. et al, 2021 ). In recent years, many carbon-based nanomaterials with antioxidant activities have been developed to regulate abnormal ROS levels in organisms due to their efficient catalytic activities like enzymes ( Das et al, 2019 ; Dehvari et al, 2020 ; Wang H. et al, 2021 ; Li et al, 2021 ; Xue et al, 2021 ; Ma et al, 2022 ). Carbon dots (CDs) nanozyme, as a “new star” among nanozymes, have potential anti-inflammatory therapeutic applications owing to their high efficiency in promoting electron transfer for scavenging ROS.…”

Section: Introductionmentioning

confidence: 99%

Carbon dots nanozyme for anti-inflammatory therapy via scavenging intracellular reactive oxygen species

Dong

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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Developing an efficient antioxidant for anti-inflammatory therapy via scavenging reactive oxygen species (ROS) remains a great challenge owing to the insufficient activity and stability of traditional antioxidants. Herein, we explored and simply synthesized a biocompatible carbon dots (CDs) nanozyme with excellent scavenging activity of ROS for anti-inflammatory therapy. As expected, CDs nanozyme effectively eliminate many kinds of free radicals including •OH, O2•−, and ABTS+•. Benefiting from multienzyme activities against ROS, CDs nanozyme can decrease the levels of pro-inflammatory cytokines, resulting in good anti-inflammatory effect. Taken together, this study not only sheds light on design of bioactive antioxidants but also broadens the biomedical application of CDs in the treatment of inflammation.

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Section: Introductionmentioning

confidence: 99%

Carbon dots nanozyme for anti-inflammatory therapy via scavenging intracellular reactive oxygen species

Dong

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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“…[ 4b ] Therefore, the selection of proper preparation methods is particularly important for Mn‐based nanozymes. In the past, the common methods for the preparation of Mn‐based nanozymes were the hydrothermal/solvothermal method, [ 33 ] chemical co‐precipitation method, [ 29,34 ] sol–gel method, [ 35 ] and other methods (e.g., microwave‐assisted method ( Figure a) [ 36 ] and ultrasonic precipitation method [ 37 ] ). The morphology, particle size, properties, and application areas of Mn‐based nanozymes are also very different due to different materials, methods, and reaction conditions.…”

Section: Preparation Of Mn‐based Nanozymesmentioning

confidence: 99%

Manganese‐Based Nanozymes: Preparation, Catalytic Mechanisms, and Biomedical Applications

Tang

Zhang

Sun

et al. 2022

Adv Healthcare Materials

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Manganese (Mn) has attracted widespread attention due to its low-cost, nontoxicity, and valence-rich transition. Various Mn-based nanomaterials have sprung up and are employed in diverse fields, particularly Mn-based nanozymes, which combine the physicochemical properties of Mn-based nanomaterials with the catalytic activity of natural enzymes, and are attracting a surge of research, especially in the field of biomedical research. In this review, the typical preparation strategies, catalytic mechanisms, advances and perspectives of Mn-based nanozymes for biomedical applications are systematically summarized. The application of Mn-based nanozymes in tumor therapy and sensing detection, together with an overview of their mechanism of action is highlighted. Finally, the prospective directions of Mn-based nanozymes from five perspectives: innovation, activity enhancement, selectivity, biocompatibility, and application broadening are discussed.

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“…Despite the fact that mimicking enzymes’ enantioselectivity is a grand challenge, recent reports are demonstrating it is possible, in topoisomerase mimicry, for example [ 307 ]. Heteroatom-doped CNDs have been developed for theranostics as well, thanks to nanozyme activity [ 308 ]. Many other examples of nanozymes based on CNDs have been reported, through addition of other components, such as hemin [ 309 ], metal nanoparticles (NPs) [ 310 , 311 ], co-doping with various elements [ 312 , 313 , 314 ], MOFs [ 315 ], carbon nitride [ 316 ], and metal oxides [ 317 ].…”

Section: Cnms For Enzyme Mimicry Inhibition or Monitoringmentioning

confidence: 99%

Carbon Nanomaterials (CNMs) and Enzymes: From Nanozymes to CNM-Enzyme Conjugates and Biodegradation

et al. 2022

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Carbon nanomaterials (CNMs) and enzymes differ significantly in terms of their physico-chemical properties—their handling and characterization require very different specialized skills. Therefore, their combination is not trivial. Numerous studies exist at the interface between these two components—especially in the area of sensing—but also involving biofuel cells, biocatalysis, and even biomedical applications including innovative therapeutic approaches and theranostics. Finally, enzymes that are capable of biodegrading CNMs have been identified, and they may play an important role in controlling the environmental fate of these structures after their use. CNMs’ widespread use has created more and more opportunities for their entry into the environment, and thus it becomes increasingly important to understand how to biodegrade them. In this concise review, we will cover the progress made in the last five years on this exciting topic, focusing on the applications, and concluding with future perspectives on research combining carbon nanomaterials and enzymes.

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Heteroatom doped carbon dots with nanoenzyme like properties as theranostic platforms for free radical scavenging, imaging, and chemotherapy

Cited by 72 publications

References 72 publications

Carbon dots nanozyme for anti-inflammatory therapy via scavenging intracellular reactive oxygen species

Carbon dots nanozyme for anti-inflammatory therapy via scavenging intracellular reactive oxygen species

Manganese‐Based Nanozymes: Preparation, Catalytic Mechanisms, and Biomedical Applications

Carbon Nanomaterials (CNMs) and Enzymes: From Nanozymes to CNM-Enzyme Conjugates and Biodegradation

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