Heteroatom modified MCM-41-silica carriers for Lomefloxacin delivery systems

Brezoiu, Ana-Maria; Deaconu, Mihaela; Nicu, Ioana; Vasile, Eugeniu; Mitran, Raul−Augustin; Matei, Cristian; Berger, Daniela

doi:10.1016/j.micromeso.2018.08.031

Cited by 47 publications

(21 citation statements)

References 57 publications

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“…As supports for polyphenolic extract loading, pristine MCM-41 silica (MCM-41E) and MCM-41 silica with pore walls decorated with ZnO nanoparticles (ZnMCM-41) were used. The synthesis procedure of these supports was previously reported [25]. The materials containing black chokeberry extract were prepared by the incipient wetness impregnation method using A. melanocarpa ethanolic extract and MCM-41E or ZnMCM-41 supports.…”

Section: Encapsulation Of the Black Chokeberry Extract Into Mesoporoumentioning

confidence: 99%

Biological Evaluation of Black Chokeberry Extract Free and Embedded in Two Mesoporous Silica-Type Matrices

et al. 2020

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Black chokeberry fruits possess a wide range of biological activities, among which the most important that are frequently mentioned in the literature are their antioxidant, anti-inflammatory, anti-proliferative, and antimicrobial properties. The present paper reports, for the first time, the encapsulation of the ethanolic extract of Aronia melanocarpa L. fruits into two mesoporous silica-type matrices (i.e., pristine MCM-41 and MCM-41 silica decorated with zinc oxide nanoparticles). The aim of this work was to evaluate the antiradicalic capacity, the antimicrobial potential, and the effects on the cell viability on a cancer cell line (i.e., A375 human melanoma cell line) versus normal cells (i.e., HaCaT human keratinocytes) of black chokeberry extract loaded on silica-type matrices in comparison to that of the extract alone. The ethanolic polyphenolic extract obtained by conventional extraction was characterized by high-performance liquid chromatography with a photodiode array detector (HPLC–PDA) and spectrophotometric methods. The extract was found to contain high amounts of polyphenols and flavonoids, as well as good radical scavenging activity. The extract-loaded materials were investigated by Fourier transform infrared spectroscopy, N2 adsorption–desorption isotherms, thermal analysis, and radical scavenger activity on solid samples. The black chokeberry extract, both free and loaded onto mesoporous silica-type matrices, exhibited a significant antioxidant capacity. Antibacterial activity was recorded only for Gram-positive bacteria, with a more potent antibacterial effect being observed for the extract loaded onto the ZnO-modified MCM-41 silica-type support than for the free extract, probably due to the synergistic effect of the ZnO nanoparticles that decorate the pore walls of silica. The cellular viability test (i.e., MTT assay) showed dose- and time-dependent activity regarding the melanoma cell line. The healthy cells were less affected than the cancer cells, with all tested samples showing good cytocompatibility at doses of up to 100 µg/mL. Improved in vitro antiproliferative and antimigratory (i.e., scratch assay) potential was demonstrated through the loading of black chokeberry extract into mesoporous silica-type matrices, and the screened samples exhibited low selectivity against the tested non-tumor cell line. Based on presented results, one can conclude that mesoporous silica-type matrices are good hosts for black chokeberry extract, increasing its antioxidant, antibacterial (on the screened strains), and in vitro antitumor (on the screened cell line) properties.

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Section: Encapsulation Of the Black Chokeberry Extract Into Mesoporoumentioning

confidence: 99%

Biological Evaluation of Black Chokeberry Extract Free and Embedded in Two Mesoporous Silica-Type Matrices

et al. 2020

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“…Since the discovery of MCM-41, researchers have taken an interest in its synthesis and application because of its large internal surface, high thermal and hydrothermal stability, possibility of controlling the pore dimension, and potential acidity. Indeed, MCM-41 has been widely studied in adsorption [3][4][5][6], CO 2 capture [7][8][9], catalysis [10][11][12], drug delivery [13,14], and biomedical applications [15] in the last five years. Traditional mesoporous silica materials were synthesized with sodium silicate, tetraethyl orthosilicate, or tetramethyl orthosilicate as silicon sources.…”

Section: Introductionmentioning

confidence: 99%

Simple Synthesis and Characterization of Hexagonal and Ordered Al–MCM–41 from Natural Perlite

Chen

et al. 2019

Minerals

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Silica reagents are expensive and toxic for use in the synthesis of mesoporous silica materials. It is imperative to take an interest in green silicon sources. In this paper, we report the synthesis of hexagonal and ordered aluminum-containing mesoporous silica materials (Al–MCM–41) from natural perlite mineral without addition of silica or aluminum reagents. A pretreatment process involving acid leaching, alkali leaching, and strongly acidic cation exchange resins treatment was critical to obtain silicon and aluminum sources from natural perlite mineral. The Al–MCM–41 material was synthesized via a hydrothermal reaction with hexadecyl trimethyl ammonium bromide (CTAB) as the template and subsequent calcination. The resulting mesophase had a hexagonal and ordered mesoporous structure, confirmed by small-angle X-ray diffraction (SAXRD) and transmission electron microscopy (TEM). Al–MCM–41 material had a high Brunauer–Emmet–Teller (BET) surface area of 1024 m2/g, pore volume of 0.72 cm3/g and an average pore diameter of 2.8 nm with a pore size distribution centered at 2.5 nm. The thermal behavior of the as-synthesized samples during calcination was investigated by thermogravimetry (TG) and differential thermogravimetry (DTG) analysis. The Al–MCM–41 material showed a negative surface charge in aqueous solution with the pH value ranging from 2 to 13. The variations of chemical structures from natural perlite to Al–MCM–41 were traced by wide-angle X-ray diffraction (WAXRD) and Fourier-transform infrared spectroscopy (FTIR). A proposed mechanism for the synthesis of hexagonal and ordered mesoporous silica materials from natural perlite is discussed.

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“…1b) recorded at the range of 0.5 to 10 show a very intense (100) Bragg diffraction and two less intense (110) and (200) diffraction peaks reections associated with a p6 mm hexagonal symmetry of the ordered MCM-41-type materials. 38 Obviously, the incorporation of heteroatoms into the silica not only decreased the peak intensity but also caused the shi of d 100 -spacing relative to undoped MCM-41. However, the shi of d 100 -spacing for LLn-MCM-41 toward to the large value, while the d 100 -spacing for HLn-MCM-41 shied to a small value.…”

Section: Resultsmentioning

confidence: 99%

“…With ordered cylindrical channels, the mesoporous MCM-41 silica nanoparticles can be used as the nanocontainer for excellent drug storage and sustained drug release properties. 31,38 Therefore, the MCM-41 nanoparticles were selected as host, and Ln 3+ ions as activators to synthesis Ln 3+ -doped MCM-41 (Ln-MCM-41) nanoparticles via the sample CTAB assisted sol-gel method. The pore distribution and luminescence properties can be easily tailored by the adjusting of Ln 3+ -doping concentration and selection of activators.…”

Section: Introductionmentioning

confidence: 99%

Lanthanide-doped mesoporous MCM-41 nanoparticles as a novel optical–magnetic multifunctional nanobioprobe

Liu

et al. 2019

RSC Adv.

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Heteroatom modified MCM-41-silica carriers for Lomefloxacin delivery systems

Cited by 47 publications

References 57 publications

Biological Evaluation of Black Chokeberry Extract Free and Embedded in Two Mesoporous Silica-Type Matrices

Biological Evaluation of Black Chokeberry Extract Free and Embedded in Two Mesoporous Silica-Type Matrices

Simple Synthesis and Characterization of Hexagonal and Ordered Al–MCM–41 from Natural Perlite

Lanthanide-doped mesoporous MCM-41 nanoparticles as a novel optical–magnetic multifunctional nanobioprobe

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