Heterobimetallic [Ru(II)/Fe(II)] complexes: On the formation of trans- and cis-[RuCl2(dppf)(diimines)]

Gallatti, Túlio F.; Bogado, André L.; Poelhsitz, Gustavo Von; Ellena, Javier; Castellano, Eduardo E.; Batista, Alzir A.; Araujo, Márcio P. de

doi:10.1016/j.jorganchem.2007.08.038

Cited by 23 publications

(6 citation statements)

References 26 publications

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“…Calc. for C 46 TBAP, scan rate 100 mV s À1 , at room temperature, with E ox = 1200 mV and E 1/2 = 1125 mV, close to those found for similar chlorine complexes containing dppb, diimines and N-heterocyclic as ligands [20,21,32,[34][35][36][37][38].…”

Section: Synthesis Of [Rucl(dppb)(55 0 -Me-bipy)(4-vpy)](pf 6 ) (3)supporting

confidence: 80%

Modified glassy carbon electrode with AuNPs using cis-[RuCl(dppb)(bipy)(4-vpy)]+ as crossed linking agent

et al. 2014

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Section: Synthesis Of [Rucl(dppb)(55 0 -Me-bipy)(4-vpy)](pf 6 ) (3)supporting

confidence: 80%

Modified glassy carbon electrode with AuNPs using cis-[RuCl(dppb)(bipy)(4-vpy)]+ as crossed linking agent

et al. 2014

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“…The process assigned to piplartine refers to the oxidation of the trimethoxybenzene group, where the proposed mechanism involves the formation of free radicals [ 38 ]. The E pa value of Ru(II)/Ru(III) oxidation processes for the precursor cis -[RuCl 2 (dppb)(bipy)] is observed around 0.65 V [ 34 , 39 ], clearly indicating that the substitution of the two chloridos by an uncharged chelate ligand (piplartine), stabilizing the Ru(II) center by approximately 1.0 V. This stabilization is plausible, due to the replacement of two σ and π donor chlorido ligands by an uncharged chelating piplartine, which increases the oxidation potential of the metal center.…”

Section: Resultsmentioning

confidence: 99%

“…The RuCl 3 .3H 2 O, 1,4-bis(diphenylphosphino)butane (dppb) 1,1-bis(diphenyl phosphino)ferrocene (dppf), 2,2’-bipyridine (bipy), were purchased from Sigma-Aldrich (Sigma-Aldrich Co., Saint Louis, MO, USA) and the piplartine was purchased from Cayman Chemical Company (Cayman Chemical, Ann Arbor, MI, USA). The precursors cis -[RuCl 2 (dppb)(bipy)] and cis -[RuCl 2 (dppf)(bipy)], were prepared according to published procedures [ 34 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

Novel piplartine-containing ruthenium complexes: synthesis, cell growth inhibition, apoptosis induction and ROS production on HCT116 cells

Irs

et al. 2017

Oncotarget

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Piplartine (piperlongumine) is a plant-derived molecule that has been receiving intense interest due to its anticancer characteristics that target the oxidative stress. In the present paper, two novel piplartine-containing ruthenium complexes [Ru(piplartine)(dppf)(bipy)](PF6)2 (1) and [Ru(piplartine)(dppb)(bipy)](PF6)2 (2) were synthesized and investigated for their cellular and molecular responses on cancer cell lines. We found that both complexes are more potent than metal-free piplartine in a panel of cancer cell lines on monolayer cultures, as well in 3D model of cancer multicellular spheroids formed from human colon carcinoma HCT116 cells. Mechanistic studies uncovered that the complexes reduced the cell growth and caused phosphatidylserine externalization, internucleosomal DNA fragmentation, caspase-3 activation and loss of the mitochondrial transmembrane potential on HCT116 cells. Moreover, the pre-treatment with Z-VAD(OMe)-FMK, a pan-caspase inhibitor, reduced the complexes-induced apoptosis, indicating cell death by apoptosis through caspase-dependent and mitochondrial intrinsic pathways. Treatment with the complexes also caused a marked increase in the production of reactive oxygen species (ROS), including hydrogen peroxide, superoxide anion and nitric oxide, and decreased reduced glutathione levels. Application of N-acetyl-cysteine, an antioxidant, reduced the ROS levels and apoptosis induced by the complexes, indicating activation of ROS-mediated apoptosis pathway. RNA transcripts of several genes, including gene related to the cell cycle, apoptosis and oxidative stress, were regulated under treatment. However, the complexes failed to induce DNA intercalation. In conclusion, the complexes are more potent than piplartine against different cancer cell lines and are able to induce caspase-dependent and mitochondrial intrinsic apoptosis on HCT116 cells by ROS-mediated pathway.

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“…All reactions were performed under a nitrogen atmosphere with the use of Schlenk techniques unless otherwise stated. Chloroform and acetonitrile were dried over molecular sieves (3 (2) [21] were prepared following literature procedures.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, structural, electrochemical, and spectroscopic studies of some (diimine)ruthenium nitrile complexes

Babgi

Asiri

Arshad

et al. 2015

Journal of Coordination Chemistry

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Heterobimetallic [Ru(II)/Fe(II)] complexes: On the formation of trans- and cis-[RuCl2(dppf)(diimines)]

Cited by 23 publications

References 26 publications

Modified glassy carbon electrode with AuNPs using cis-[RuCl(dppb)(bipy)(4-vpy)]+ as crossed linking agent

Modified glassy carbon electrode with AuNPs using cis-[RuCl(dppb)(bipy)(4-vpy)]+ as crossed linking agent

Novel piplartine-containing ruthenium complexes: synthesis, cell growth inhibition, apoptosis induction and ROS production on HCT116 cells

Synthesis, structural, electrochemical, and spectroscopic studies of some (diimine)ruthenium nitrile complexes

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