Heterodimers Made of Upconversion Nanoparticles and Metal–Organic Frameworks

Abstract

Creating nanoparticle dimers has attracted extensive interest. However, it still remains a great challenge to synthesize heterodimers with asymmetric compositions and synergistically enhanced functions. In this work, we report the synthesis of high quality heterodimers composed of porphyrinic nanoscale metal-organic frameworks (nMOF) and lanthanide-doped upconversion nanoparticles (UCNPs). Due to the dual optical properties inherited from individual nanoparticles and their interactions, absorption of low energy photons by the UCNPs is followed by energy transfer to the nMOFs, which then undergo activation of porphyrins to generate singlet oxygen. Furthermore, the strategy enables the synthesis of heterodimers with tunable UCNP size and dual NIR light harvesting functionality. We demonstrated that the hybrid architectures represent a promising platform to combine NIR-induced photodynamic therapy and chemotherapy for efficient cancer treatment. We believe that such heterodimers are capable of expanding their potential for applications in solar cells, photocatalysis, and nanomedicine.

An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy

“…In vivo MRI imaging. The in vivo MRI imaging experiments were conducted on MCF-7 tumor-bearing female mice when the tumor volume reached about 100 mm 3 . MSNs or (MSNs@CaO 2 -ICG)@LA ([MSNs] = 5 mg kg −1 ) were intratumorally injected into the tumor sites.…”

“…Thus, cancer cells are more sensitive to further enhanced oxidative stress beyond the cellular tolerability threshold 2 . On this basis, ROS-mediated therapies, such as photodynamic therapy (PDT) [3][4][5][6] and chemodynamic therapy (CDT) [7][8][9][10][11] , are developed to disrupt the cellular self-adaptation mechanisms and induce cell death based on ROS-generating agents 12 .…”

Photodynamic Therapy Based on Nanoscale Metal–Organic Frameworks: From Material Design to Cancer Nanotherapeutics

“…In 2017, nanoheterostructured UCMOFs consisting of UCNPs and MOFs were reported by Yan et al . When the UCNPs were irradiated with a 980 nm laser, Yb 3+ transferred energy to Er 3+ and produced characteristic emission bands of 522, 541, and 654 nm corresponding to the 2 H 11/2 → 4 I 15/2 , 4 S 3/2 → 4 I 15/2 , and 4 F 9/2 → 4 I 15/2 transitions.…”

Fluorescence Detection and Dissociation of Amyloid‐β Species for the Treatment of Alzheimer's Disease

“…Of late, PDT is considered to be a promising modality for treating tumors, [67][68][69][70][71][72][73][74][75][76] glaucoma, and so on [77] because of its advantages, including minimal invasiveness and high spatial selectivity. [80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95] More importantly, by employing their unique merits, UCNPs have also shown potential application in inhibiting Aβ aggregation. [79] To address these challenges, rare earth upconversion nanoparticles (UCNPs) have been utilized as energy transducers to indirectly activate PS by using NIR light as excitation source.…”