Heterodyne frequency‐domain multispectral diffuse optical tomography of breast cancer in the parallel‐plane transmission geometry

Ban, Han Y.; Schweiger, Martin; Kavuri, Venkaiah C.; Cochran, Jeffrey M.; Xie, Li; Busch, David R.; Katrašnik, Jaka; Pathak, S.; Chung, Sukmin; Lee, K.; Choe, Regine; Czerniecki, Brian J.; Arridge, Simon; Yodh, Arjun G.

doi:10.1118/1.4953830

Cited by 24 publications

(18 citation statements)

References 80 publications

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“…Compared to these imaging modalities, near infrared spectroscopy (NIRS) and spectral tomography (NIRST) provide potential advantages due to their noninvasive nature, relatively low cost and portable size [7][8][9]. Pilot studies have shown that NIRS and NIRST can assess the intrinsic biophysical composition of tissue, in terms of absorber concentrations of deoxy-hemoglobin (Hb) and oxy-hemoglobin (HbO), water and lipids [10][11][12], as well as the scattering signatures attributed to ultra-structural cellular density and size ensemble associated with the extracellular matrix and subcellular constituents in healthy breast tissues [13,14]. These can differentiate malignant from benign pathology [15,16], and have shown success in monitoring the tumor response to treatments [17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Collagen quantification in breast tissue using a 12-wavelength near infrared spectral tomography (NIRST) system

Zhao

Burger

Zhou

et al. 2017

Biomed. Opt. Express

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A portable near infrared spectral tomography (NIRST) system was adapted for breast cancer detection and treatment monitoring with improved speed of acquisition for parallel 12 wavelengths of parallel frequency-domain (FD) and continuous-wavelength (CW) measurement. Using a novel gain adjustment scheme in the Photomultiplier Tube detectors (PMTs), the data acquisition time for simultaneous acquisition involving three FD and three CW wavelengths, has been reduced from 90 to 55 seconds, while signal variation was also reduced from 2.1% to 1.1%. Tomographic images of breast collagen content have been recovered for the first time, and image reconstruction approaches with and without collagen content included have been validated in simulation studies and normal subject exams. Simulations indicate that including collagen content into the reconstruction procedure can significantly reduce the overestimation in total hemoglobin, water and lipid by 8.9M, 1.8% and 15.8%, respectively, and underestimates in oxygen saturation by 9.5%, given an average 10% background collagen content. A breast cancer patient with invasive ductal carcinoma was imaged and the reconstructed images show that the recovered tumor/background contrast in total hemoglobin increased from 1.5 to 1.7 when collagen was included in reconstruction.

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Section: Introductionmentioning

confidence: 99%

Collagen quantification in breast tissue using a 12-wavelength near infrared spectral tomography (NIRST) system

Zhao

Burger

Zhou

et al. 2017

Biomed. Opt. Express

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“…Диффузионное приближение к уравнению переноса излучения (УПИ) довольно точно описывает баланс энергии в сильно рассеивающих средах, таких как био-логические ткани или их фантомы [3,8,16]. Плотность потока фотонов для множества моделируемых точек с координатами x, y, z может быть представлена как функция времени или как функция частоты [17]. Цели данной работы наиболее соответствует диффузионное приближение к УПИ для ультракоротких импульсов (функция времени) следующего вида [10]:…”

Section: моделирование миграции фотонов в сильно рассеивающих средах unclassified

Численное Моделирование Миграции Фотонов В Однородных И Неоднородных Цилиндрических Фантомах

Потлов¹,

Фролов²,

Проскурин³

2020

Журнал Технической Физики

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The specific features of photon diffusion of low-coherence pulsed irradiation in phantoms of soft biological tissues (blood-saturated tissues of the brain, breast, etc.) are described. The results of photon migration simulation using the Diffusion Approximation to the Radiation Transfer Equation (RTE) are compared with ones of the Monte Carlo simulations. It has been confirmed that the Photon Density Normalized Maximum (PDNM) moves towards the center of the investigated object in case of relatively uniform and strongly scattering media. In the presence of inhomogeneities, type of the PDNM motion changes drastically. Presence of an absorbing inhomogeneity in the medium directs trajectory of the PDNM motion of towards the point symmetric to the inhomogeneity relative to the geometric center of the investigated object. In case of scattering the PDNM moves toward the direction of the center of the scattering inhomogeneity.

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“…The value of the transport index describes specific tissue cellular structure, while the value of the coefficient of absorption enables the evaluation of biological chromophore concentration (oxyhemoglobin, deoxyhemoglobin, water, fats, collagen, etc.) [48][49][50][51]. The total hemoglobin concentration reflects blood filling of the tissue, shows oxygen supply, deoxyhemoglobin reflects its consumption.…”

Section: Diffuse Optical Spectroscopymentioning

confidence: 99%

Current Methods for the Assessment of Oxygen Status and Biotissue Microcirculation Condition: Diffuse Optical Spectroscopy (Review)

Бесчастнов¹,

Ryabkov²,

Pavlenko³

et al. 2018

Sovrem Tehnol Med

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The problem of studying the oxygen status and biotissue microcirculation is of special interest for many directions in medical science since one of the causes of hypoxia development as a typical pathophysiological process is a microcirculatory "failure" associated with the impairment of normal anatomy of the capillary wall, changes in the rheological blood properties, acceleration or slowdown of the blood flow. Current imaging techniques enable the researchers to study the processes of biosystem vital activity at various levels: from organs and tissues to the substance molecular composition. Methods of functional bioimaging implemented into clinical practice provide the opportunity of watching online the processes of substance movement in the body, monitoring blood flow parameters, assessing hypoxia level, characterizing metabolism in greater detail, and, at the same time, correcting timely pathological conditions. The main advantages and disadvantages of bioimaging examination methods such as BOLD functional magnetic resonance tomography, positron emission tomography, optical imaging, laser Doppler flowmetry, and transcutaneous oximetry are considered in the present review. Special attention is paid to diffuse optical spectroscopy as a noninvasive method of lifetime study of substance content in biotissues. The principle of diffuse optical spectroscopy is based on the ability of tissue chromophores (oxyhemoglobin, deoxyhemoglobin, fatty acids, collagen) to absorb diffusely scattered light of a definite wavelength. Their concentrations are calculated with the allowance for the absorption coefficients of chromophores. Diffuse optical spectroscopy is being introduced in clinical practice to diagnose the degree of tumor malignization, evaluate vascularization in reconstructive operations, diagnose hypoxic tissue conditions, monitor intraoperatively blood flow parameters, measure hypoxia levels in diabetes mellitus. It provides the possibility to define and make clear indications to skin plastic surgery and, conceivably, to develop new methods of skin plasty.

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Heterodyne frequency‐domain multispectral diffuse optical tomography of breast cancer in the parallel‐plane transmission geometry

Abstract: Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated.

Cited by 24 publications

References 80 publications

Collagen quantification in breast tissue using a 12-wavelength near infrared spectral tomography (NIRST) system

Collagen quantification in breast tissue using a 12-wavelength near infrared spectral tomography (NIRST) system

Численное Моделирование Миграции Фотонов В Однородных И Неоднородных Цилиндрических Фантомах

Current Methods for the Assessment of Oxygen Status and Biotissue Microcirculation Condition: Diffuse Optical Spectroscopy (Review)

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