Heterogeneity and genetic variations of serotypes O and Asia 1 foot-and-mouth disease viruses isolated in Vietnam

Le, Van Phan; Nguyen, Tung; Park, Jong Hyeon; Kim, Su-Mi; Ko, Young-Joon; Lee, Hyang-Sim; Nguyen, Van Cam; Duong, Thuy Yen; Hoa, T.T.T.; Cho, In‐Soo; Lee, Kwang-Nyeong

doi:10.1016/j.vetmic.2010.04.005

Cited by 26 publications

(24 citation statements)

References 33 publications

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“…FMDV serotypes A and O currently circulate in Vietnam, while serotype Asia 1 has not been reported in Vietnam since 2008 [7–9]. FMDV serotype O is the most prevalent in the country; a recent study sequenced 71 serotype O viruses from samples collected between 2009 and 2013 in Vietnam, 65 of these viruses belonged to O/ME-SA/PanAsia lineage, while only 6 were classified as O/SEA/Mya-98 [6, 8]. However, in Vietnam from 2014–2016 it is believed that there has been a resurgence of O/SEA/Mya-98 (Dung and Long, unpublished data).…”

Section: Introductionmentioning

confidence: 99%

Phylodynamics of foot-and-mouth disease virus O/PanAsia in Vietnam 2010–2014

Brito

Pauszek

Eschbaumer

et al. 2017

Vet Res

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Foot-and-mouth disease virus (FMDV) is endemic in Vietnam, a country that plays an important role in livestock trade within Southeast Asia. The large populations of FMDV-susceptible species in Vietnam are important components of food production and of the national livelihood. In this study, we investigated the phylogeny of FMDV O/PanAsia in Vietnam, reconstructing the virus’ ancestral host species (pig, cattle or buffalo), clinical stage (subclinical carrier or clinically affected) and geographical location. Phylogenetic divergence time estimation and character state reconstruction analyses suggest that movement of viruses between species differ. While inferred transmissions from cattle to buffalo and pigs and from pigs to cattle are well supported, transmission from buffalo to other species, and from pigs to buffalo may be less frequent. Geographical movements of FMDV O/PanAsia virus appears to occur in all directions within the country, with the South Central Coast and the Northeast regions playing a more important role in FMDV O/PanAsia spread. Genetic selection of variants with changes at specific sites within FMDV VP1 coding region was different depending on host groups analyzed. The overall ratio of non-synonymous to synonymous nucleotide changes was greater in pigs compared to cattle and buffalo, whereas a higher number of individual amino acid sites under positive selection were detected in persistently infected, subclinical animals compared to viruses collected from clinically diseased animals. These results provide novel insights to understand FMDV evolution and its association with viral spread within endemic countries. These findings may support animal health organizations in their endeavor to design animal disease control strategies in response to outbreaks.Electronic supplementary materialThe online version of this article (doi:10.1186/s13567-017-0424-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Phylodynamics of foot-and-mouth disease virus O/PanAsia in Vietnam 2010–2014

Brito

Pauszek

Eschbaumer

et al. 2017

Vet Res

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“…The concurrent circulation of FMD outbreaks of the FMDV serotype O, A, and Asia 1 and its genetic variation may apply pressure for the selection of effective vaccine strains to prevent and control FMDV outbreaks in Vietnam [15]. These points also suggest that more FMDV surveillance studies will be necessary in order to evaluate the genetic relationship and efficacy of the current used vaccines against different FMDV serotypes circulating in Vietnam.…”

Section: Discussionmentioning

confidence: 99%

“…The FMDV serotype O and its outbreak in Vietnam were first described in academic research between 1996 and 2001 [14]. The FMDV serotype Asia 1 and A were subsequently identified in 2005 and 2009, respectively [12, 15]. In 2008 and the first 2 months of 2009, the FMDV serotypes O and A were reported to be the prevalent serotype and caused approximately 166 FMD outbreaks in 128 communes in 47 districts of 14 provinces throughout the country [16].…”

Section: Introductionmentioning

confidence: 99%

Evolutionary phylodynamics of foot-and-mouth disease virus serotypes O and A circulating in Vietnam

Vu²,

Duong

et al. 2016

BMC Vet Res

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BackgroundFoot-and-mouth disease virus (FMDV) is one of the highest risk factors that affects the animal industry of the country. The virus causes production loss and high ratio mortality in young cloven-hoofed animals in Vietnam. The VP1 coding gene of 80 FMDV samples (66 samples of the serotype O and 14 samples of the serotype A) collected from endemic outbreaks during 2006–2014 were analyzed to investigate their phylogeny and genetic relationship with other available FMDVs globally.ResultsPhylogenetic analysis indicated that the serotype O strains were clustered into two distinct viral topotypes (the SEA and ME-SA), while the serotype A strains were all clustered into the genotype IX. Among the study strains, the amino acid sequence identities were shared at a level of 90.1–100, 92.9–100, and 92.8–100% for the topotypes SEA, ME-SA, and genotype IX, respectively. Substitutions leading to changes in the amino acid sequence, which are critical for the VP1 antigenic sites were also identified. Our results showed that the studied strains are most closely related to the recent FMDV isolates from Southeast Asian countries (Myanmar, Thailand, Cambodia, Malaysia, and Laos), but are distinct from the earlier FMDV isolates within the genotypes.ConclusionsThis study provides important evidence of recent movement of FMDVs serotype O and A into Vietnam within the last decade and their genetic accumulation to be closely related to strains causing FMD in surrounding countries.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-016-0896-0) contains supplementary material, which is available to authorized users.

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“…Some big outbreaks were recorded around the world such as in the UK (2001), Italia (1993) or Taiwan (1997) [1]. In Vietnam, the FMD circulates every year mainly with O, A and Asia 1 types [2,3]. Causative agent of FMD is FMD virus (FMDV) which exists at 7 types (O, A, C, Asia 1, SAT1, SAT2, SAT3) and more than 60 serotypes.…”

Section: Introductionmentioning

confidence: 99%

Expression and Purification Capsid Proteins Vp0, Vp1 and Vp3 of Foot and Mouth Disease Virus Type O in Escherichia Coli

Duong¹,

Chuang²,

Hoa³

et al. 2016

JST

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Foot and mouth disease virus (FMDV) causing infectious disease affects broadly clovenhoofed animals. It has 7 different serotypes. However, type O is the most prevalent in 3 founded types (O, A, Asia1) recurrence in Vietnam fields. The current vaccines used for FMDV is inactivated or attenuated forms. FMDV Vaccines were able to raise strong immune responses in host organisms, but still caused the safety concerns. Virus-like particles could be a new vaccine generation that fulfills the present questions. On the one hand, it can tackle the safety issues, on the other hand, it can reserve FMDV intrinsic form which will provoke high immunogenicity. The important initial step to make virus-like particles is expression of the capsid proteins of FMDV in appropriate system. So in this study we describe how to design, express and purify of all capsid proteins: VP0, VP1 and VP3 of O type FMDV isolated in Vietnam field using SUMO fusion expression system.

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Heterogeneity and genetic variations of serotypes O and Asia 1 foot-and-mouth disease viruses isolated in Vietnam

Cited by 26 publications

References 33 publications

Phylodynamics of foot-and-mouth disease virus O/PanAsia in Vietnam 2010–2014

Phylodynamics of foot-and-mouth disease virus O/PanAsia in Vietnam 2010–2014

Evolutionary phylodynamics of foot-and-mouth disease virus serotypes O and A circulating in Vietnam

Expression and Purification Capsid Proteins Vp0, Vp1 and Vp3 of Foot and Mouth Disease Virus Type O in Escherichia Coli

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