Heterogeneity in allergic rhinitis: Explained by inducible mechanistic traits?

Wijk, Roy Gerth van; Smits, Hermelijn H.

doi:10.1016/j.jaci.2021.06.011

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…1 ). 18 Furthermore, climate change has also increased the production of various aeroallergens and changes in their geographical distribution. Changes in the flowering season due to climate changes have extended allergenic seasons with consequent increases in human exposure.…”

Section: Allergic Rhinitis Classification Redefinedmentioning

confidence: 99%

“…1 Heterogeneity of allergic rhinitis: Inducible mechanistic traits. Adapted from Gerth van Wijk and Smits, 2021 18 CD8, cluster of differentiation 8; NK, natural killer; Th2, Type 2 helper. Allergic rhinitis patients exhibit heterogeneous clinical traits, including monosenstization to polysensitization for various allergens combined with mild-to-persistent and/or moderate typical rhinitis complaints, together with comorbidities for asthma, such as airway hyperresponsiveness …”

Section: Allergic Rhinitis Classification Redefinedmentioning

confidence: 99%

See 1 more Smart Citation

Pollen respiratory allergy: Is it really seasonal?

D’Amato

Murrieta‐Aguttes

D’Amato

et al. 2023

World Allergy Organization Journal

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Section: Allergic Rhinitis Classification Redefinedmentioning

confidence: 99%

Section: Allergic Rhinitis Classification Redefinedmentioning

confidence: 99%

Pollen respiratory allergy: Is it really seasonal?

D’Amato

Murrieta‐Aguttes

D’Amato

et al. 2023

World Allergy Organization Journal

View full text Add to dashboard Cite

Identifying allergic-rhinitis-associated genes with random-walk-based method in PPI network

Li,

Huang,

Zhang

et al. 2024

Computers in Biology and Medicine

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Multi‐omic integration reveals alterations in nasal mucosal biology that mediate air pollutant effects on allergic rhinitis

Irizar,

Chun,

Hsu

et al. 2024

Allergy

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BackgroundAllergic rhinitis is a common inflammatory condition of the nasal mucosa that imposes a considerable health burden. Air pollution has been observed to increase the risk of developing allergic rhinitis. We addressed the hypotheses that early life exposure to air toxics is associated with developing allergic rhinitis, and that these effects are mediated by DNA methylation and gene expression in the nasal mucosa.MethodsIn a case–control cohort of 505 participants, we geocoded participants' early life exposure to air toxics using data from the US Environmental Protection Agency, assessed physician diagnosis of allergic rhinitis by questionnaire, and collected nasal brushings for whole‐genome DNA methylation and transcriptome profiling. We then performed a series of analyses including differential expression, Mendelian randomization, and causal mediation analyses to characterize relationships between early life air toxics, nasal DNA methylation, nasal gene expression, and allergic rhinitis.ResultsAmong the 505 participants, 275 had allergic rhinitis. The mean age of the participants was 16.4 years (standard deviation = 9.5 years). Early life exposure to air toxics such as acrylic acid, phosphine, antimony compounds, and benzyl chloride was associated with developing allergic rhinitis. These air toxics exerted their effects by altering the nasal DNA methylation and nasal gene expression levels of genes involved in respiratory ciliary function, mast cell activation, pro‐inflammatory TGF‐β1 signaling, and the regulation of myeloid immune cell function.ConclusionsOur results expand the range of air pollutants implicated in allergic rhinitis and shed light on their underlying biological mechanisms in nasal mucosa.

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Heterogeneity in allergic rhinitis: Explained by inducible mechanistic traits?

Cited by 3 publications

References 10 publications

Pollen respiratory allergy: Is it really seasonal?

Pollen respiratory allergy: Is it really seasonal?

Identifying allergic-rhinitis-associated genes with random-walk-based method in PPI network

Multi‐omic integration reveals alterations in nasal mucosal biology that mediate air pollutant effects on allergic rhinitis

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