Heterogeneity in calcium nephrolithiasis: A materials perspective

Sherer, Benjamin A.; Chen, Ling; Yang, Feifei; Ramaswamy, Krishna; Killilea, David W.; Hsi, Ryan S.; Stoller, Marshall L.; Ho, Sunita P.

doi:10.1557/jmr.2017.153

Cited by 6 publications

(8 citation statements)

References 35 publications

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“…In this study, five such specimens were obtained and were characterized using micro-CT and scanning electron microscopy techniques. Micro-CT revealed distinctions in mineral density between stem and stones with stones expressing heterogeneity largely by virtue of varying elemental composition [14]. Electron microscopy and micro-CT of these stems has revealed, in some cases, patent lumens of diameters equal to that of the tubules, thin loops of Henle within the renal tip (Fig 4; D3-D5).…”

Section: Discussionmentioning

confidence: 99%

“…Gaussian distributions were generated to best fit the distribution of tubule diameters and the peak of the Gaussian curve was taken as the representative tubular diameter. When the absolute difference between peak values was at least the sum of two half-widths of the half-maximum of the peaks, the tubules were considered to be of distinct structures/diameters [14].…”

Section: Methodsmentioning

confidence: 99%

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Novel insights into renal mineralization and stone formation through advanced imaging modalities

Wiener

Chen

Shimotake

et al. 2018

Connective Tissue Research

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Observations were patterned through a novel and unified theory of stepwise-architecture guided biomineralization (a combination of smaller structures leading to a larger but similar structural framework). A plausible stepwise progression in renal biomineralization is proposed; proximal intratubular calcium phosphate deposits can lead to interstitial yet calcium phosphate rich RP and mature into a stem on which a calcium oxalate stone grows within the collecting system of a kidney.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Novel insights into renal mineralization and stone formation through advanced imaging modalities

Wiener

Chen

Shimotake

et al. 2018

Connective Tissue Research

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“…A histogram of the tubule diameters showed several peaks and Gaussian functions were generated to best fit the distribution with the peak as a representative value tubule diameter. Significant differences in peak values were considered if the absolute difference between peak values was at least the sum of two half-widths at the half-maximum of the peaks, which in essence is same as full width at half maximum should it be only one peak [10].…”

Section: Methodsmentioning

confidence: 99%

A continuum of mineralization from human renal pyramid to stones on stems

et al. 2018

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Nephrolithiasis is a common condition affecting nearly 1 in 11 Americans. The most common type of stone, calcium oxalate is known to form on a calcium phosphate deposit on the renal papilla known as Randall's plaque. Novel imaging techniques have identified distinct regions of biomineralization not just at the tip, but throughout the renal papilla. The classic understanding of Randall's plaque formation is reformulated using correlative imaging techniques. This study establishes a stepwise progression of anatomically-specific biomineralization events including, 1) proximal intratubular mineralization within the renal pyramid; 2) interstitial Randall's plaque near the tip of the papilla; 3) emerging plaque (stems); and, 4) the body of heterogeneous stones, and provides insights into the need for plausible site-specific therapeutic intervention.

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“…C. Mineral density and structure analyses of stones with micro-X-ray computed tomography (micro-CT) Intact stone specimens were scanned at 40 kVp peak voltage and at 4X magnification using micro-X-ray computed tomography (Micro-XCT 200, Carl Zeiss Microscopy, Pleasanton, California). Mineral densities were calculated following a detailed calibration protocol of the micro-CT [4,5]. Mineral density analyses were undertaken using AVIZO ® software (9.0.2, FEI, Hillsboro, Oregon).…”

Section: B In Vitro Calcium Ceftriaxone Crystal Formationmentioning

confidence: 99%

Structure and elemental composition of Ceftriaxone induced pediatric nephrolithiasis

Kang

Mena

et al. 2021

Urolithiasis

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Ceftriaxone is a widely used antibiotic because to its broad-spectrum gram-negative coverage, safety, and biological half life (5-9 h) permit dose once-daily administration. It is specifically used in pediatric patients in developing countries. Ceftriaxone forms insoluble sludge/stone when combined with calcium in the urinary system. In this study, Ceftriaxone induced sludge/stones from pediatric patients were collected to identify its microstructure and composition to gather insights into the mechanism of Ceftriaxone induced sludge/stone formation. The results illustrated that Ceftriaxone induced stones formed rapidly following antibiotic administration. Ceftriaxone calcium salt crystals could easily be broken with minimal intervention. However, Ceftriaxone combined with calcium phosphate formed an insoluble stone aggregate.

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Heterogeneity in calcium nephrolithiasis: A materials perspective

Abstract: Abstract

Cited by 6 publications

References 35 publications

Novel insights into renal mineralization and stone formation through advanced imaging modalities

Novel insights into renal mineralization and stone formation through advanced imaging modalities

A continuum of mineralization from human renal pyramid to stones on stems

Structure and elemental composition of Ceftriaxone induced pediatric nephrolithiasis

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