Heterogeneity of gestational diabetes (GDM) and long-term risk of diabetes and metabolic syndrome: findings from the RADIEL study follow-up

Abstract

ClinicalTrials.gov, www.clinicaltrials.com , NCT01698385.

Precision medicine in type 2 diabetes

“…There is also emerging evidence for shared genetic background of GDM and T2D . Similar to T2D, GDM can also be heterogeneous, especially in different ethnic groups .…”

Heterogeneity of gestational diabetes (GDM) and challenges in developing a GDM risk score

“…To assess the heterogeneity of GDM we divided the women into four groups (A, B, C, D) according to their pre-pregnancy BMI, parity, and history of GDM, similar to our previous studies [10,15]. Group A: obese primiparous women, group B: multiparous obese women without GDM history, group C: multiparous non-obese women with previous GDM, and group D: multiparous obese women with previous GDM.…”

Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?

“…When the threshold level for hyperinsulinemia was taken as 15 IU/mL, seven (25.9%) patients in the GDM group and four (13.3%) patients in the control group had hyperinsulinemia (Table 4). This was syndrome and cardiovascular disease is seven times higher in these patients 5,[31][32][33][34][35] . In our study, mean arterial systolic and diastolic blood pressure values and total cholesterol, LDL, VLDL and triglyceride levels were higher in GDM group compared to the control group.…”