Heterogeneous Catalyzed Reduction of Polymer-Bound Nitroarenes

Chemoselective Reduction of Nitroarenes in the Presence of Acid-Sensitive Functional Groups: Solid-Phase Syntheses of Amino Aryl Azides and Benzotriazoles

“…Despite a very long list of possible reducing agents and an even larger variation of reaction conditions, most selective and powerful reducing media are either acidic (typically SnCl 2 ) or use heterogeneous methods (e.g., Fe/HCl). However, these methods are unsuitable for acid-labile molecules, on solid supports, or both. , Because most linkers for solid-phase syntheses are acid-labile, there is a great need for methods for the chemoselective reduction of nitroarenes on solid supports under neutral or basic conditions. , …”