Heterogenous changes in neuropeptide Y, norepinephrine and epinephrine concentrations in the hearts of diabetic rats

Kuncová, Jitka; Švíglerová, Jitka; Tonar, Zbyněk; Slavikova, Jana

doi:10.1016/j.autneu.2005.05.005

Cited by 26 publications

(20 citation statements)

References 40 publications

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“…The reduction in the glucose levels of the diabetic control animals may also be due to partial recovery. Similar results were obtained by Kunkova et al (27) that partial spontaneous recovery of diabetes was associated with increased neuropeptide Y (NPY) levels in the atria . There was significant (p<0.05) increase in the activity of SOD and reduced glutathione level.…”

Section: Discussionsupporting

confidence: 85%

Protective influence of vitamin E on the antioxidant defence system in the whole blood and liver of normal and alloxan-induced diabetic rats

Olanlokun

2008

Indian J Clin Biochem

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The effect of oral administration of vitamin E for twenty-eight consecutive days on blood glucose, reduced glutathione levels, antioxidant enzymes (superoxide dismutase and catalase activities), and levels of malondialdehyde (as an index of free radical-mediated lipid peroxidation) was observed in the whole blood and liver of normal and alloxan-induced diabetic rats. It was found that oral administration of vitamin E significantly (p<0.05) lowered the blood glucose level and increased the body weight of the diabetic rats. The activities of superoxide dismutase and levels of reduced glutathione increased significantly (p<0.05) while the level of lipid peroxidation decreased.

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Section: Discussionsupporting

confidence: 85%

Protective influence of vitamin E on the antioxidant defence system in the whole blood and liver of normal and alloxan-induced diabetic rats

Olanlokun

2008

Indian J Clin Biochem

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“…NPY is a major norepinephrine co-transmitter in postganglionic sympathetic nerves and cardiac intrinsic neurons (Kuncova et al, 2005; Pardini et al, 1992). NPY gene expression was augmented in the RAA of patients with left heart disease and the increased NPY gene expression correlated with both atrial gene expression of Aogen and the catecholamine-synthesizing enzyme TH.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue

Nagata

Varagić

Kon

et al. 2015

Therapeutic Advances in Cardiovascular Disease

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Objective Heart chymase rather than angiotensin converting enzyme has higher specificity for angiotensin (Ang) I conversion into Ang II in humans. A new pathway for direct cardiac Ang II generation has been revealed through the demonstration that Ang-(1-12) is cleaved by chymase to generate Ang II directly. We address here whether Ang-(1-12) and chymase gene expression and activity are detected in the atrial appendages of 44 patients (10 females) undergoing heart surgery for the correction of valvular heart disease, resistant atrial fibrillation or ischemic heart disease. Methods and Results Immunoreactive- (Ir-) Ang-(1-12) expression was 54% higher in left atrial compared to right atrial appendages and this was associated with higher abundance of left atrial appendage chymase gene transcripts and chymase activity but no differences in angiotensinogen mRNA. Atrial chymase enzymatic activity was highly correlated with left atrial but not right atrial enlargement as determined by echocardiography while both tyrosine hydroxylase and NPY atrial appendages mRNAs correlated with atrial angiotensinogen mRNAs. Conclusions Higher Ang-(1-12) expression and upregulation of chymase gene transcripts and enzymatic activity from the atrial appendages connected to the enlarged left versus right atrial chambers of subjects with left heart disease defines a role of this alternate Ang II forming pathway in the processes accompanying adverse atrial and ventricular remodeling.

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“…Indeed, several reports suggested that STZ-injected female rats showed signs of partial spontaneous regeneration with increased circulating and pancreatic insulin levels within 1 year of the disease duration. 34,35) Such partial recovery from STZ-induced diabetes has been also found in adult rats treated with low concentration of STZ.…”

Section: Discussionmentioning

confidence: 66%

Effect of Long-Term Diabetes on Serotonin-Mediated Contraction in Carotid Arteries from Streptozotocin-Induced Diabetic Male and Female Rats

Watanabe

Matsumoto

Ando

et al. 2016

Biological & Pharmaceutical Bulletin

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An accumulating body of evidence suggests that males and females differ in vascular function in arteries under pathophysiological states. In this study, we tested whether there was a sex difference associated with serotonin (5-hydroxytryptamine, 5-HT)-mediated contraction in the carotid arteries of long-term streptozotocin (STZ)-induced diabetic rats [viz. 23 or 24 weeks after STZ (65 mg/kg, intravenously (i.v.)) injection starting at 8 weeks old of rats]. In the control group, the 5-HT-and high-K -induced contractions were greater in females than in males. In both sexes, treatment with STZ led to a decrease of 5-HT-induced contraction in carotid arteries compared to controls. In STZ-induced diabetic rats, the carotid arterial 5-HTinduced contraction was greater in female rats than in diabetic male rats. The high-K -induced contraction was greater in diabetic female rats than in either age-matched female controls or diabetic male rats. Expression of the 5-HT 2A receptor, which is the main receptor for 5-HT-induced contraction in rat carotid arteries, was similar among the four groups. These results suggest that decreased 5-HT-induced carotid arterial contraction is seen in both sexes under long-term STZ-induced diabetic conditions. Further, this reduction seems to be weaker in females than in males. This alteration of 5-HT-induced contraction may be partly associated with increased voltage-dependent Ca 2 channel activity.Key words carotid artery; contraction; serotonin; sex difference; streptozotocin Although women generally develop cardiovascular diseases several years later than men, this benefit may be diminished in diabetic individuals. The results of numerous epidemiological studies investigating the relationship between sex and the development of cardiovascular disease in diabetics have been inconsistent.1,2) Alterations in the responsiveness of blood vessels to various hormones and/or neurotransmitters in patients of both sexes with diabetes mellitus are well established. [3][4][5][6] However, there is confounding evidence of vascular function between diabetics of both male and females.The neurotransmitter serotonin [5-hydroxytriptamine (5-HT)] is an important factor that is involved in the regulation of several vascular functions, including blood flow, blood pressure, and vascular tone, in pathophysiological states. 7-9)Several reports by our research team [10][11][12] and others 3,[13][14][15] have found that alterations in vasocontraction induced by 5-HT were observed in patients with cardiovascular diseases as well as in those with diabetes. An accumulating body of evidence suggests that 5-HT plays a role in the development of diabetic complications. For example, sarpogrelate, an antagonist of the 5-HT 2A receptor, has beneficial effects against diabetic nephropathy, neuropathy, and diabetes-associated vascular dysfunction, including arterial stiffness and arteriosclerosis, in diabetic patients and animal models. [16][17][18][19] This relevant evidence suggests that the manipulation of 5-HT function c...

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Heterogenous changes in neuropeptide Y, norepinephrine and epinephrine concentrations in the hearts of diabetic rats

Cited by 26 publications

References 40 publications

Protective influence of vitamin E on the antioxidant defence system in the whole blood and liver of normal and alloxan-induced diabetic rats

Protective influence of vitamin E on the antioxidant defence system in the whole blood and liver of normal and alloxan-induced diabetic rats

RETRACTED: Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue

Effect of Long-Term Diabetes on Serotonin-Mediated Contraction in Carotid Arteries from Streptozotocin-Induced Diabetic Male and Female Rats

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