Heterometallic ZnHoMOF as a Dual-Responsive Luminescence Sensor for Efficient Detection of Hippuric Acid Biomarker and Nitrofuran Antibiotics

Abstract

Developing efficient and sensitive MOF-based luminescence sensors for bioactive molecule detection is of great significance and remains a challenge. Benefiting from favorable chemical and thermal stability, as well as excellent luminescence performance, a porous Zn(II)Ho(III) heterometallic–organic framework (ZnHoMOF) was selected here as a bifunctional luminescence sensor for the early diagnosis of a toluene exposure biomarker of hippuric acid (HA) through “turn-on” luminescence enhancing response and the daily monitoring of NFT/NFZ antibiotics through “turn-off” quenching effects in aqueous media with high sensitivity, acceptable selectivity, good anti-interference, exceptional recyclability performance, and low detection limits (LODs) of 0.7 ppm for HA, 0.04 ppm for NFT, and 0.05 ppm for NFZ. Moreover, the developed sensor was employed to quantify HA in diluted urine samples and NFT/NFZ in natural river water with satisfactory results. In addition, the sensing mechanisms of ZnHoMOF as a dual-response chemosensor in efficient detection of HA and NFT/NFZ antibiotics were conducted from the view of photo-induced electron transfer (PET), as well as inner filter effects (IFEs), with the help of time-dependent density functional theory (TD-DFT) and spectral overlap experiments.

A dual‐responsive luminescent sensor for efficient detection of 3‐nitrotyrosine and dipicolinic acid biomarkers based on copper(II) organic framework

“…Benefiting from the highly ordered arrangement of organic linkers and inorganic blocks, metal–organic frameworks (MOFs) were endowed with the structural features of adjustable architecture, readily modifiable confined space, and large surface area 13–21 . These unique characteristics promoted MOFs vast applicability as chemosensors in detecting water‐soluble toxic ions or cations, volatile organic compounds, and nitroaromatic explosives 22–30 .…”

Three-Dimensional Hydrogen-Bonded Porous Metal-Organic Framework for Natural Gas Separation with High Selectivity

“…Metal-organic frameworks, as self-assembled porous materials, have been widely explored in the last two decades due to their excellent performance in the areas of gas storage and separation [ 1 , 2 ], heterogeneous catalysis [ 3 ], drug delivery [ 4 ], luminescence [ 5 , 6 , 7 ], electrochemistry [ 8 ], and magnetism [ 9 ]. The structure and properties of MOFs depend on the nature of their metal cations and bridging ligands.…”

RSM optimization of Friedel–Crafts C-acylation of para-fluorophenol over the catalysis of phosphomolybdic acid encapsulated in MIL-53 (Fe) metal organic frameworks

“…[11][12][13][14][15][16] These materials' adaptable structure enables a wide range of chemical processes, such as catalysis, photocatalysis, electrocatalysis, adsorption, separation, sensing, drug administration, and organic transformation. [16][17][18][19][20] The acidity of MOFs can be tuned by changing the metal node or ligand's functional group, allowing for the selective activation of specic functional groups in the reactants. 21 In particular, supported phosphomolybdic acid catalysts have been used in various organic reactions, including esterication, transesterication, aldol condensation, Friedel-Cras acylation, etc.…”