Heterophile Antibodies in Sera of Patients with Chediak-Higashi Syndrome

Tamura, Takahiro; Merino, Fernando; Kano, Kyoichi; Ramı́rez-Duque, Pedro; Milgrom, Felix

doi:10.1159/000233463

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…Dicha mutación en LYST es la responsable de la disfunción fagocitaria e infecciones piógenas a repetición, lo cual se evidencia en antecedentes de abscesos cutáneos a repetición y debut con neumonía en el paciente presentado. En la línea roja, se describen anticuerpos heterófilos (IgG e IgM) contra componentes eritrocitarios, (11) y matriz lipídica anormal en la membrana de los eritrocitos originando disfunción en las proteínas de membrana, (12) con alteraciones en el transporte de calcio dependiente de ATP, al igual que en la membrana lisosomal de neutrófilos; (13) presentan alteraciones en la agregación y función plaquetaria. (14) Desde el momento de su ingreso este paciente presentó alteración de las tres líneas celulares, siendo congruente con la revisión de literatura.…”

Section: Discussionunclassified

El niño plateado: Síndrome de Chediak-Higashi

Planchet

Russián

Rodríguez

et al. 2023

RDP

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El Síndrome de Chediak-Higashi (SCH) es una patología de herencia autosómica recesiva debido principalmente a mutaciones del gen regulador del tráfico lisosómico (LYST), causando grados dermatológicamente diferentes de albinismo óculocutáneo, infecciones recurrentes, disfunción fagocítica primaria, en el desarrollo y proliferación de todas las líneas celulares. Se presenta caso de preescolar masculino de 2 años de edad, ingresado por aumento de volumen bilateral en región cervical y fiebre, en malas condiciones generales, con áreas de hiperpigmentación en piel, cabello y cejas de coloración grisácea, adenopatías generalizadas y visceromegalias; leucocitosis con linfocitosis y neutropenia, anemia, trombocitopenia, hipoalbuminemia, hipertrigliceridemia e hiperferritinemia; en vista de la infrecuente coexistencia de dichas características con albinismo óculocutáneo; es evaluado por hematología y dermatología evidenciándose inclusiones citoplasmáticas y melanosomas gigantes, respectivamente, compatibles con SCH, confirmándose diagnóstico. El conocimiento del SCH es importante para la oportuna sospecha clínica-diagnóstica e inicio de protocolos terapéuticos en consenso, que garanticen un manejo eficaz para su sobrevida.

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Section: Discussionunclassified

El niño plateado: Síndrome de Chediak-Higashi

Planchet

Russián

Rodríguez

et al. 2023

RDP

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“…SRBCs in routine laboratory practice are used to detect heterophile antibodies. ese antibodies are characteristically found in the sera of patients su ering from infectious mononucleosis, along with other clinical conditions, where the serum levels of heterophile antibodies have also been related to disease activity (Duverlie et al, 1989;Yoshida et al, 1980;Satoh et al, 1980;Moore and Dorner, 1980;Tamura et al, 1984). Since heterophile antibodies can be detected in an otherwise healthy population (Kakoma et al, 1987) their presence in the serum samples, sent to the laboratory for routine investigations and their ability to interfere with the results, cannot be ignored.…”

Section: Discussionmentioning

confidence: 99%

Modifications Influencing Widal Test Reactivity in a Novel Microplate Assay

Almogren¹,

Shakoor²,

Adam³

et al. 2012

Pol J Microbiol

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Reliability of the Widal tube agglutination test has been the subject of many controversies over the years. This study was performed to assess the effect of certain modifications on the performance of Widal test in a novel microplate assay. Sera from 37 patients (21 males; 16 females) (mean age 28 +/- 7 years) were tested in the Immunology Unit at King Khalid University Hospital, Riyadh. Among them were 26 patients with suspected typhoid fever and 11 had bacteriologically confirmed diagnosis of Salmonella infection. The modifications included either the use of 0.5% bovine serum albumin (BSA), absorption of sera with sheep red blood cells (SRBC) or heat inactivation of sera. Compared with Widal tube agglutination test, microplate assay with SRBC absorption of the sera from patients with suspected typhoid fever was not only associated with enhancement of detection titers for both H (p < or = 0.001) and O (p < or = 0.005) Salmonella agglutinins but also the percentage of reactivity. The presence of BSA augmented detection titers for Salmonella H agglutinins (p < or = 0.02) only. Heat inactivation of sera however was found to be associated with reduction in the detectable titers for both H (p < or = 0.03) and O (p < or = 0.01) agglutinins. Increased titers of Salmonella agglutinins were also evident in 11 patients with confirmed diagnosis of Salmonella infection. The novel microplate agglutination assay using the SRBC absorption was associated with enhancement in Widal test reactivity and appears to be a useful alternative for the diagnosis of Salmonella infection.

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“…Our previous studies [7,11,12] by EIA with HMWGP of BRBC have demonstrated H-D antibod ies predominantly of IgM class in various diseases such as infectious mononucleosis, seropositive syphi lis, Chediak-Higashi disease and Kawasaki disease. In the present study, H-D antibodies of the IgG class were found in liver disease sera; 6% in acute hepatitis, 28% in chronic hepatits and 22% in liver cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Studies on Hanganutziu-Deicher Antigens-Antibodies

Morito¹,

Nishimaki²,

Masaki³

et al. 1986

Int Arch Allergy Immunol

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Sera of patients with various liver diseases were examined for the presence of Hanganutziu-Deicher (H-D) antibodies by enzyme immunoassay with high-molecular weight glycoprotein (HMWGP) isolated from bovine red blood cell stromata. IgG class H-D antibodies were demonstrated in sera of 5.9% of acute hepatitis, 28.1 % of chronic hepatitis and 21.9% of liver cirrhosis patients. H-D specificity of the antibodies under investigation was determined by absorption experiments. Evidence was also presented that the H-D antibodies in the liver disease sera are directed to N-glycolyl neuraminic acid (NGNA) and/or NGNA-dependent determinants of HMWGP.

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Heterophile Antibodies in Sera of Patients with Chediak-Higashi Syndrome

Cited by 7 publications

References 12 publications

El niño plateado: Síndrome de Chediak-Higashi

El niño plateado: Síndrome de Chediak-Higashi

Modifications Influencing Widal Test Reactivity in a Novel Microplate Assay

Studies on Hanganutziu-Deicher Antigens-Antibodies

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