Heterophilic interactions of DM-GRASP: GRASP-NgCAM interactions involved in neurite extension.

DeBernardo, Angela P.; Chang, Sun Ju

doi:10.1083/jcb.133.3.657

Cited by 82 publications

(68 citation statements)

References 47 publications

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“…E587 Ag is a member of the L1 family of cell adhesion molecules (Giordano et al, 1997) and therefore may interact with other Ig CAMs. The chick homolog of L1, G4/NgCAM , is able to bind axonin-1 (Kuhn et al, 1991), F11 (Brü mmendorf et al, 1993, and DM-GRASP (DeBernado and Chang, 1996), the fish homolog of which is neurolin (Laessing et al, 1994). The functional relevance of these interactions has been determined in vitro.…”

Section: Discussionmentioning

confidence: 99%

Expression of an L1-Related Cell Adhesion Molecule on Developing CNS Fiber Tracts in Zebrafish and Its Functional Contribution to Axon Fasciculation

Weiland

Ott

Bastmeyer

et al. 1997

Molecular and Cellular Neuroscience

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E587 antigen, an L1-related cell adhesion molecule, is expressed by growing axons and has previously been shown to enhance axon growth and to mediate fasciculation of axons from newborn retinal ganglion cells in goldfish. In zebrafish, the monoclonal antibody E17 against E587 antigen stains all axons in the primary tracts and commissures from 17 h postfertilization (pf) onward and axons which are added subsequently to this scaffold. Moreover, Fab fragments of an E587 antiserum (E587 Fabs) injected into the ventricle of 30-h pf zebrafish embryos caused a marked defasciculation of distinct axon bundles in the posterior commissure, in hindbrain commissures, and in longitudinal tracts of the hindbrain, where they also caused increased crossings between fascicles. The regulated expression of E587 antigen by all developing axons and the effects caused by E587 Fabs show that E587 antigen contributes to the formation of tight and orderly fascicles in the developing CNS.

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Section: Discussionmentioning

confidence: 99%

Expression of an L1-Related Cell Adhesion Molecule on Developing CNS Fiber Tracts in Zebrafish and Its Functional Contribution to Axon Fasciculation

Weiland

Ott

Bastmeyer

et al. 1997

Molecular and Cellular Neuroscience

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“…However, coreceptors have been implicated in L1-mediated outgrowth previously. The FGF receptor (Williams et al, 1994), TAG-1/axonin-1 (Buchstaller et al, 1996), neuropilin-1 (Castellani et al, 2000), and activated leukocyte cell adhesion molecule (DeBernardo and Chang, 1996) have been suggested to be L1 coreceptors. The fact that L1-1147 has good single neurite outgrowth but significantly reduced branching number suggests that the coreceptor can support single neurite outgrowth but does not participate in the initiation of branching.…”

Section: A Coreceptor Is Implicated In L1-mediated Neurite Outgrowthmentioning

confidence: 99%

L1-Mediated Branching Is Regulated by Two Ezrin-Radixin-Moesin (ERM)-Binding Sites, the RSLE Region and a Novel Juxtamembrane ERM-Binding Region

2005

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We investigated how the neural cell adhesion molecule L1 mediates neurite outgrowth through L1-L1 homophilic interactions. Wild-type L1 and L1 with mutations in the cytoplasmic domain (CD) were introduced into L1 knock-out neurons, and transfected neurons were grown on an L1 substrate. Neurite length and branching were compared between wild-type L1 and L1CD mutations. Surprisingly, the L1CD is not required for L1-mediated neurite outgrowth but plays a critical role in neurite branching, through both the juxtamembrane region and the RSLE region. We demonstrate that both regions serve as ezrin-moesin-radixin-binding sites. A truncation mutant that deletes 110 of 114 amino acids of the L1CD still supports neurite outgrowth on an L1 substrate, suggesting that a coreceptor binds to L1 in cis and mediates neurite outgrowth and that L1-ankyrin interactions are not essential for neurite initiation or outgrowth. These data are consistent with a model in which L1 can influence L1-mediated neurite outgrowth and branching through both the L1CD and a coreceptor.

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“…The homophilic properties of SC1 have been revealed using cellular adhesion experiments on substrates and self-aggregation assays in vitro (8,(11)(12)(13). By contrast, previous studies have also reported heterophilic interactions of SC1, such as that with neuron-glia (Ng)-CAM during the extension of neurites from sympathetic neurons as well as that with CD6 in the hematopoietic system (14,15). SC1 homologs have been confirmed in zebrafish, mice, rats and humans (16).…”

Section: Introductionmentioning

confidence: 98%

SC1, an immunoglobulin-superfamily cell adhesion molecule, is involved in the brain metastatic activity of lung cancer cells

Kubota¹,

Kirimura²,

Shiba³

et al. 2015

Oncology Letters

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Abstract. SC1 is a cell adhesion molecule that belongs to the immunoglobulin superfamily; this molecule was initially purified from the chick embryonic nervous system and was reported to exhibit homophilic adhesion activity. SC1 is transiently expressed in various organs during development and has been identified in numerous neoplastic tissues, including lung cancer and colorectal carcinomas. The present study focused on the encephalic metastasis of lung cancer cells with respect to the potential function of SC1, as this molecule is known to be consistently expressed in the central nervous system as well as lung cancers. SC1 complementary DNA was introduced into A549 cells, a human lung cancer-derived cell line. The stable overexpression of the SC1 protein in A549 cells was demonstrated to enhance the self-aggregation of the cells. In addition, the SC1 transfectants enhanced the metastatic and invasive potential to the encephalic parenchyma following implantation into nude mice. In conclusion, the results of the present study demonstrated that cell adhesion due interactions between SC1 on brain tissue and SC1 on lung cancer cells was involved in the malignant aspects of lung cancer, including invasion and metastasis to the brain. IntroductionNumerous studies have confirmed that cell adhesion molecules (CAMs) are essential for normal histogenesis as well as tumor malignancies (1-3). In addition, it was reported that dysregulated CAM expression was often involved in certain tumor behavior (4,5). Of note, the inhibition or attenuation of E-cadherin expression in epithelial cells was demonstrated to enhance cellular transformation. A certain CAM, deleted in colorectal cancer (DCC), is a member of the immunoglobulin (Ig) superfamily, which is commonly lost during the development of colorectal tumors. The loss of expression of CAMs, such as DCC, has therefore been suggested to enable the migration and escape of tumor cells from the primary lesion, subsequently resulting in the invasion and the dissemination of metastases. By contrast, various other CAMs have been reported to be overexpressed in numerous types of tumors, which may promote tumor cell invasion and metastasis through their adhesive activities (4,6).SC1 is a cell adhesion molecule that belongs to the Ig superfamily; this molecule was identified in several independent studies, each of which gave it a different title, SC1, bursal epithelium and neurons or DM-general receptor for phosphoinositides 1-associated scaffold protein (7-10). This protein possesses an intracellular domain that carries three C2-type Ig-like motifs followed by two V-type motifs. The homophilic properties of SC1 have been revealed using cellular adhesion experiments on substrates and self-aggregation assays in vitro (8,(11)(12)(13). By contrast, previous studies have also reported heterophilic interactions of SC1, such as that with neuron-glia (Ng)-CAM during the extension of neurites from sympathetic neurons as well as that with CD6 in the hematopoietic system (14,15). SC1 homologs hav...

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Heterophilic interactions of DM-GRASP: GRASP-NgCAM interactions involved in neurite extension.

Cited by 82 publications

References 47 publications

Expression of an L1-Related Cell Adhesion Molecule on Developing CNS Fiber Tracts in Zebrafish and Its Functional Contribution to Axon Fasciculation

Expression of an L1-Related Cell Adhesion Molecule on Developing CNS Fiber Tracts in Zebrafish and Its Functional Contribution to Axon Fasciculation

L1-Mediated Branching Is Regulated by Two Ezrin-Radixin-Moesin (ERM)-Binding Sites, the RSLE Region and a Novel Juxtamembrane ERM-Binding Region

SC1, an immunoglobulin-superfamily cell adhesion molecule, is involved in the brain metastatic activity of lung cancer cells

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