Heterotopic Bone Formation in a Synthetic Sponge

Winter, George D.

doi:10.1177/003591577006311p115

Cited by 20 publications

(5 citation statements)

References 9 publications

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“…The random distribution of macrophages, established by Poisson evaluation, in the tissues adjacent to the implanted Hydron would indicate that the macrophages were neither attracted to nor repulsed by the Hydron, Calcification observed at the interface of the implant material and soft tissues In intramuscular Hydron implants from the longer time periods appeared similar to that illustrated by Sprinel et al (1973) in their investigation of macroporous HEMA gel. Similar results were obtained by Winter andSimpson (1969) andWinter (1970), Sprinel et al (1973) described their results as follows: 'deposition of compounds giving a positive reaction to calcium in the margin of the implant is massivethe central part is uncalcifled'. The stimulus for this deposition of calcium remains conjectural.…”

Section: Discussionsupporting

confidence: 75%

Tissue responses assessed by intramuscular implantation

et al. 1992

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Freshly mixed polymerized Hydron root canal filling material, fully set AH26 and Teflon were implanted in the quadriceps muscle of guinea pigs and assessed histologically at 2 days, 1, 2, 3, 12 and 26 weeks after implantation. All materials were characterized by peri-implant fibrous connective tissue capsule formation. Von Kossa-positive calcific material was observed at the implant-tissue interface of Hydron implants. The amount of apparently calcified material increased with time. Inflammation was not a prominent tissue response for any of the test materials, nor was a foreign body giant cell response.

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Section: Discussionsupporting

confidence: 75%

Tissue responses assessed by intramuscular implantation

et al. 1992

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“…Consequently, minerals (e.g. DCPD [25] and calcium carbonate [26]), oxide layers on metals [27] and polymers [15,28] are known to form an apatitic layer in the body and so the surface that is implanted may not remain at the same composition during implantation.…”

Section: Calcium Phosphate Bone Graft Substitutesmentioning

confidence: 99%

Bioinorganics and biomaterials: Bone repair

2011

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“…Although the water content of these hydrogels is fairly low (^25%) they demonstrate excellent mechanical properties. Poly(glyceryl methacrylate) hydrogels exhibit a considerably higher equilibrium water content than P-HEMA gels (28,(60)(61)(62)(63)(64)(65)(66)(67)(68)(69)(70)(71). Therefore it has often been thought that this material might show a higher degree of biocompatibility than P-HEMA.…”

Section: IImentioning

confidence: 99%