Heterotopic Bone Formation Produced by Epithelial Transplants From Urogenital Tract of Dogs, Rabbits, Guinea-Pigs and Cats: With Notes on Apparent Inhibitory Effect of Parathyroidectomy on Bone Formation

Bone Formation Induced by Epithelium Of Urinary Bladder

“…This is not always the case with mucosa transplants to the anterior rectus sheath as shown by Abbott et al (1938) and confirmed in these experiments.…”

“…This work was confirmed by Makin (1962). That normal vesical mucosa has secretory activity was proved by Alvarez-Ierena (1952). They transplanted the ure¬ ters to the skin in dogs and found that the isolated bladder had secretory activity.…”

Human urinary bladder-carcinoma cells are non-osteoinductive

“…As an analogy of the osteoinductive potency of dog or guinea-pig transitional epithelium [1,10,11], some authors suggest that the human neoplastic transitional epithelium acts as an inductive agent for heterotopic osteogenesis and the mesenchymal cells of cancer stroma are more susceptible to the c a r t i l a g e -or bone-inducing factors of the epithelial cells.…”

“…In nine implants prepared from four cases (noninvasive papillary transitional-cell carcinoma of the bladder and invasive papillary transitionalcell carcinoma of the bladder, two cases each) a small amount of cartilage and/or bone was found in the stroma of grafted tissue. The rarity of this phenomenon -together with the observation that implants of normal human urinary-tract mucosa have never induced the formation of cartilage/bone, whereas in a similar system, dog or guineapig grafts are osteogenic -suggests that the cartilage/bone present in the stroma of implanted cancers is the result of metaplasia of the stroma of the neoplasm and not the product of any osteoinductive potency of human urothelium.Heterotopic osteogenesis following urinary-tract mucosa implantation is a phenomen observed in many species, such as dogs, cats, rabbits, gerbils, and guinea pigs, but the osteogenic potential varies among species [ 1,11,21 ]. Some species, such as mice and rats, respond well to xenogeneic transitional epithelial transplants, whereas on transplantation into auto-or allogeneic systems, their own Correspondence to: K. H. W{odarski urinary-tract epithelia only occasionally induce bone formation [3, 20].…”

“…Heterotopic osteogenesis following urinary-tract mucosa implantation is a phenomen observed in many species, such as dogs, cats, rabbits, gerbils, and guinea pigs, but the osteogenic potential varies among species [ 1,11,21 ]. Some species, such as mice and rats, respond well to xenogeneic transitional epithelial transplants, whereas on transplantation into auto-or allogeneic systems, their own Correspondence to: K. H. W{odarski urinary-tract epithelia only occasionally induce bone formation [3,20].…”