Heterotopic salivary gland tissue in the neck

Haemel, Anna; Gnepp, Douglas R.; Carlsten, James; Robinson‐Bostom, Leslie

doi:10.1016/j.jaad.2007.11.009

Cited by 38 publications

(31 citation statements)

References 17 publications

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“…They can present as a chronic draining sinus, mass, cyst, or nodule on the International Journal of Surgical Pathology 19 (3) right lateral aspect of the neck. [3][4][5] The heterotopic tissue may also give rise to benign or malignant tumors, including pleomorphic adenoma, Warthin's tumor, mucoepidermoid carcinoma, acinic cell carcinoma, and adenocarcinoma, NOS. 3,5,6 Aberrant salivary glands of the lower neck are thought to be associated with the cervical sinus of His, which belongs to the branchial apparatus.…”

Section: Discussionmentioning

confidence: 99%

Benign Salivary Gland Tissue Inclusion in a Pulmonary Hilar Lymph Node From a Patient With Invasive Well-Differentiated Adenocarcinoma of the Lung: A Potential Misinterpretation for the Staging of Carcinoma

et al. 2010

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Benign epithelial and nonepithelial inclusions have been found in lymph nodes in multiple body sites. These inclusions have been seen in cervical, axillary, mediastinal, abdominal, and pelvic lymph nodes. They appear as benign epithelial, parathyroid, decidual, mesothelial, angiolipomatous, nevus cells, or Tamm-Horsfall protein. Although heterotopic salivary gland tissue is not infrequent in paraparotid lymph nodes, it has only been described in lymph nodes of the pulmonary hilum once. A 68-year-old woman with gastric lymphoma now in remission presented for routine follow-up and was found to have a lung mass. After a fine needle aspiration biopsy diagnosis of adenocarcinoma, lobectomy and lymph node dissection were performed. Histological sections of lung demonstrated a well-differentiated adenocarcinoma and one lymph node, which displayed a subcapsular nest of well-formed salivary glands occupying approximately one third of the nodal tissue. The inclusion was composed of acinar cells of both serous and mucinous types, but ductal type of cells were not seen. Identification of heterotopic tissue in lymph nodes is of great importance for patient management. Misdiagnosing benign glandular inclusions for metastasis could potentially lead to incorrect tumor staging. Benign salivary gland tissue inclusions should be considered in the differential diagnosis when evaluating for metastatic adenocarcinoma. The salivary gland inclusion in pulmonary hilar lymph node may be histogenetically related to the minor salivary glands, which are located within the bronchial submucosa.

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Section: Discussionmentioning

confidence: 99%

Benign Salivary Gland Tissue Inclusion in a Pulmonary Hilar Lymph Node From a Patient With Invasive Well-Differentiated Adenocarcinoma of the Lung: A Potential Misinterpretation for the Staging of Carcinoma

et al. 2010

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“…The authors were not able to determine if the tissue was ectopic salivary gland tissue or if it had developed through a metaplastic process [14,15]. Ectopic salivary gland tissue-normal salivary gland tissue located in an abnormal anatomical location-has been described in areas as diverse as the anterior cheek, lower anterior sternocleidomastoid muscle, parathyroid, muscles of the tongue, mandible, middle ear, pituitary, mediastinum, prostate, vulva, and rectum [16][17][18][19][20][21]. As with all ectopic tissues, ectopic salivary gland tissue can undergo neoplastic transformation, with Warthin tumors and pleomorphic adenomas being the most commonly described neoplasms [17,[19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Basal cell adenocarcinoma arising in salivary gland metaplasia of the breast: a novel salivary gland–type tumor developing in the breast

et al. 2012

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“…Cases generally present at birth or by early childhood, but they are rarely diagnosed in adulthood. 8 …”

Section: Discussionmentioning

confidence: 99%

Heterotopic Salivary Gland Presenting as a Discharging Sinus in the Base of the Neck

Jain

Aggarwal

Deshmukh

et al. 2011

Clinics and Practice

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We report a case of congenital heterotopic salivary gland with draining sinus in the lower neck on the right side of a 10-year-old female, which we initially thought to be a branchial fistula. Heterotopic salivary glands are rare lesions in the neck and when present appear very similar to branchial cleft sinus or fistula. This congenital lesion is rare. This is probably the first report from India. It is important to report this case to raise the awareness of this condition.

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Heterotopic salivary gland tissue in the neck

Cited by 38 publications

References 17 publications

Benign Salivary Gland Tissue Inclusion in a Pulmonary Hilar Lymph Node From a Patient With Invasive Well-Differentiated Adenocarcinoma of the Lung: A Potential Misinterpretation for the Staging of Carcinoma

Benign Salivary Gland Tissue Inclusion in a Pulmonary Hilar Lymph Node From a Patient With Invasive Well-Differentiated Adenocarcinoma of the Lung: A Potential Misinterpretation for the Staging of Carcinoma

Basal cell adenocarcinoma arising in salivary gland metaplasia of the breast: a novel salivary gland–type tumor developing in the breast

Heterotopic Salivary Gland Presenting as a Discharging Sinus in the Base of the Neck

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