Heterotopic thyroid autotransplantation: A preliminary clinical study

Sakr, Mahmoud; Elkerm, Yasser; Abo-Elwafa, Waleed; Mahmoud, Ahmed; Fathi, Ibrahim

doi:10.1002/hed.24904

Cited by 7 publications

(14 citation statements)

References 21 publications

(56 reference statements)

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“…Also, these reports were clustered according to their geographical distribution. In Figure 7 , it is possible to observe the geographical distribution of the studies, half of which were conducted in the US and Middle East [ 2 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 70 ]. The sample size for the most numerous study is over 240 patients.…”

Section: Resultsmentioning

confidence: 99%

Cryopreserved Thyroid Tissue Autotransplant in Pediatric Age Patients: A Feasibility Study and Literature Review

Spinelli,

Ghionzoli,

Sahli

et al. 2024

Cancers

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Background and aims: This paper aims to study an alternative solution to hormonal replacement therapy in specific groups of patients who underwent thyroidectomy during childhood or adulthood. After cryopreservation, thyroid autotransplantation could be an alternative solution which would allow us to use the ability of the thyroid tissue of producing hormones according to the physiological needs of the body. Materials and methods: A feasibility study about the effects of the most modern cryopreservation techniques on the structural and functional integrity of the follicular cells of the thyroid tissue has been carried out. Patients who could benefit from the treatment have been found for both autotransplant techniques. Additionally, a literature review has been conducted. Results: The histological analysis has shown that cryopreservation does not alter the original architecture, and the culture examination that cell viability is successfully preserved. Moreover, both thyroid autotransplantation studies on animals and those on humans that were found in the literature have shown good results regarding the viability and functionality of the transplant. Conclusions: The viability of cryopreserved thyroid tissue found in this study is encouraging. Further studies to evaluate the levels of FT3, FT4 and thyroglobulin in thyroid tissue after cryopreservation are needed to verify that the secretory properties of the thyrocytes have been maintained intact. Furthermore, autotransplanted cases found in the literature do not have a long-term follow-up.

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Section: Resultsmentioning

confidence: 99%

Cryopreserved Thyroid Tissue Autotransplant in Pediatric Age Patients: A Feasibility Study and Literature Review

Spinelli,

Ghionzoli,

Sahli

et al. 2024

Cancers

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“…When the 99m Tc radioisotope enters the bloodstream, it is homogeneously distributed throughout the body, after which it is eliminated, mainly, by the digestive and renal systems, as attested in the scintigraphy exams previously performed. 19 22 23 …”

Section: Discussionmentioning

confidence: 99%

“…99m Tc has both satisfactory sensitivity and high Positive Predictive Value (PPV), respectively 79% and 100%, for screening remaining tissue after total thyroidectomy. 23 In addition, this radioisotope was chosen over the others, especially 131 I, because it is not an organized substance (it does not remain inside the gland), interfering with hormonal values. In the 14th week, all animals of the TG presented uptake at the graft site (right thigh).…”

Section: Discussionmentioning

confidence: 99%

Rat thyroid graft transplantation after cryopreservation with scintigraphic standardization for an experimental study

Schanaider

Barboza

Vasconcellos

et al. 2022

Clinics

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“…techniques (immediate transplantation versus cryopreservation), in addition to several different locations of the implanted tissue, have been found. Finally, different types of grafts (culture or emulsion versus thyroid fragments) and postoperative follow-up times have been used (1,8,(11)(12)(13)(14)(15)(16)(17).…”

Section: Figure 3 | (A)mentioning

confidence: 99%

Cryopreserved Rat Thyroid Autotransplantation in the Treatment of Postoperative Hypothyroidism

et al. 2021

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To verify the viability and functionality of cryopreserved thyroid autotransplantation in rats who underwent total thyroidectomy in the treatment of postoperative hypothyroidism. Thirty-two Wistar rats were randomly assigned into groups (G) with eight animals each: control (CG); simulation (SG); hypothyroidism (HTG) and transplanted (TG). At the beginning and in the 13th week of the experiment, serum levels of total T3, free T4, TSH and calcium were determined. In both the first and 14th weeks, scintigraphic examinations, 99m-Tc pertechnetate radioisotope biodistribution and histopathology were performed. In the 14th week, the expression of proliferating cell nuclear antigen (PCNA) and cellular apoptosis (caspase-3) were also evaluated. In the 13th week, the transplanted animals had normal serum levels of total T3 and free T4. TSH levels showed a tendency towards normality. In the 14th week, scintigraphic exams displayed graft isotopic uptake in all animals in the TG group. Histological examinations 13 weeks after transplantation showed the viability and functionality of thyroid follicles. PCNA revealed significant immunoreactivity of the graft (p < 0.001) when the TG was compared to the CG. There was no difference between CG and TG considering the expression of activated caspase-3. The experimental study confirmed the viability and functionality of thyroid autotransplantation implanted in skeletal muscle with evidence of cell proliferation without cellular apoptosis. This surgical strategy was effective in the treatment of postoperative hypothyroidism.

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Heterotopic thyroid autotransplantation: A preliminary clinical study

Abstract: Background: Thyroid autotransplantation offers an attractive alternative to subtotal thyroidectomy and replacement therapy. However, it has not been sufficiently clinically investigated.

Cited by 7 publications

References 21 publications

Cryopreserved Thyroid Tissue Autotransplant in Pediatric Age Patients: A Feasibility Study and Literature Review

Cryopreserved Thyroid Tissue Autotransplant in Pediatric Age Patients: A Feasibility Study and Literature Review

Rat thyroid graft transplantation after cryopreservation with scintigraphic standardization for an experimental study

Cryopreserved Rat Thyroid Autotransplantation in the Treatment of Postoperative Hypothyroidism

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