Heterotransplantation of a Human Malignant Tumour to “Nude” Mice

Rygaard, Jørgen; Povlsen, C. O.

doi:10.1111/j.1699-0463.1969.tb04520.x

Cited by 627 publications

(148 citation statements)

References 3 publications

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“…Nude mice preserve the morphology and genetics of primary tumors and are thus commonly used to study tumor MDR (Rygaard, Povlsen, 1969;Shen et al, 2005;Li et al, 2005). In this study, combined treatment with cDDP and GSTsi significantly restored the sensitivity of transplanted tumor cells to cDDP, suggesting that recombinant lentivirus targeting the GST-π gene can successfully reverse the chemoresistance of esophageal cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Roles of GST-π and polβ Genes in Chemoresistance of Esophageal Carcinoma Cells

Tang

Xing²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Roles of GST-π and polβ Genes in Chemoresistance of Esophageal Carcinoma Cells

Tang

Xing²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Until today, using human cells or primary tumor tissues to produce xenograft models have become the main method of current in-vivo tumor research (Rygaard & Povlsen, 1969).…”

Section: Development Of Anti-tumor Modelsmentioning

confidence: 99%

The application of antitumor drug-targeting models on liver cancer

Yan¹,

Chen²,

Wang³

et al. 2015

Drug Delivery

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Hepatocarcinoma animal models, such as the induced tumor model, transplanted tumor model, gene animal model, are significant experimental tools for the evaluation of targeting drug delivery system as well as the pre-clinical studies of liver cancer. The application of antitumor drug-targeting models not only furnishes similar biological characteristics to human liver cancer but also offers guarantee of pharmacokinetic indicators of the liver-targeting preparations. In this article, we have reviewed some kinds of antitumor drug-targeting models of hepatoma and speculated that the research on this field would be capable of attaining a deeper level and expecting a superior achievement in the future.

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“…It is important to implant the xenograft into the immunocompromised mice and commonly the T-cell deficient ''nude'' mice or NOD-SCID (non-obese diabetic/severe combined immunodeficiency) mice are used (Rygaard & Povlsen, 1969). The xenograft models of CRC are commonly used to assess newer therapeutics and understand the pathogenesis of human disease.…”

Section: Xenograft Models Of Colon Cancermentioning

confidence: 99%