The application of antitumor drug-targeting models on liver cancer

Abstract

Hepatocarcinoma animal models, such as the induced tumor model, transplanted tumor model, gene animal model, are significant experimental tools for the evaluation of targeting drug delivery system as well as the pre-clinical studies of liver cancer. The application of antitumor drug-targeting models not only furnishes similar biological characteristics to human liver cancer but also offers guarantee of pharmacokinetic indicators of the liver-targeting preparations. In this article, we have reviewed some kinds of antitumor drug-targeting models of hepatoma and speculated that the research on this field would be capable of attaining a deeper level and expecting a superior achievement in the future.

Andrographolide nanophytosomes exhibit enhanced cellular delivery and pro-apoptotic activities in HepG2 liver cancer cells

“…Nanomedicine has sparked a significant interest in terms of enhancing the delivery of several drugs as well as overcoming their pharmacological limitations. The incorporation of phytochemicals into nanocarriers showed improvements in their stability, solubility, bioavailability and tumor-targeting effect (Yan et al., 2016 ; Qi et al., 2017 ). Phytosome (PTM) has been used to enhance the anticancer activity of phytochemical compounds (Alhakamy, Badr-Eldin et al., 2020 ; Alhakamy, Fahmy et al., 2020 ; Alhakamy et al., 2021 ; Al-Rabia et al., 2022 ).…”

Efficient Delivery of Curcumin by Alginate Oligosaccharide Coated Aminated Mesoporous Silica Nanoparticles and In Vitro Anticancer Activity against Colon Cancer Cells

“…Nano drug delivery systems are represented by polymers, nanocapsules, polymer micelles [5], liposomes [6], inorganic nanoparticles such as gold [7], graphene [8], mesoporous silicon [9], and polydopamine [10], have been widely used in tumor therapy. By endowing the common anticancer drugs with the specificity of targeted delivery, anti-tumor activity can be improved [11]. NDDS mainly rely on the forces between surface groups and molecules, including van der Waals forces and hydrogen bonds, so that drug molecules can be dissolved, adsorbed, or covalently bound to the surface of particles.…”