Hexachlorobenzene-Induced Effects on the Lymphocyte Blastogenic Response to Concanavalin a in the Mink and European Ferret

Bleavins, Michael R.; Aulerich, R. J.; Ringer, Robert K.

doi:10.1897/1552-8618(1983)2[411:heotlb]2.0.co;2

Cited by 5 publications

(5 citation statements)

References 7 publications

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“…Decrease in the lymphocyte proliferation by mitogen Con-A (14.23% Table-2 ) is an indication of suppression of T-cell blastogenesis, which is essential for mounting of both the cell-mediated and humoral immune response. Earlier, workers have also reported [ 28 ] reduced lymphocyte blastogenesis response in minks and ferrets exposed to hexachlorobenzene. Depression in cell-mediated immune response in pesticide fed birds, as observed in this study, has also been reported in broilers as measured by lymphocytes migration inhibition test [ 29 ] and lymphocyte stimulation test (LST) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide dye method [ 25 , 27 , 30 ].…”

Section: Resultsmentioning

confidence: 92%

Effect of endosulfan on immunological competence of layer birds

et al. 2016

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Aim:The present study was aimed to investigate the immunological competence of endosulfan insecticide after limited oral administration in White Leghorn layer chickens.Materials and Methods:A total of 20 White Leghorn birds were given endosulfan in drinking water at 30 ppm/bird/day (no observable effect level dose) for a period of 3-months. Immune competence status of layer birds and chicks hatched from endosulfan offered birds were estimated at 15-day interval in layer birds and at monthly interval in chicks using immunological, biochemical parameters, and teratological estimates.Results:There was a significant decrease in levels of total leukocytes count, absolute lymphocyte count, absolute heterophil count, total serum protein, serum albumin, serum globulin, and serum gamma globulin in the birds fed with endosulfan as compared to control. Similarly, immune competence tests such as lymphocyte stimulation test, oxidative burst assay, and enzyme-linked immunosorbent assay tests indicated lower immunity in birds treated with endosulfan as compared to control. Subsequently, chicks produced from endosulfan-treated birds were also examined for immune competence, but no significant difference was observed between chicks of both the groups.Conclusion:The exposure to endosulfan in limited oral dosage was able to exhibit hemo-biochemical and other changes that could be correlated with changes in the immunological profile of layer chickens suggesting cautious usage of endosulfan insecticide in poultry sheds.

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Section: Resultsmentioning

confidence: 92%

Effect of endosulfan on immunological competence of layer birds

et al. 2016

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“…Decrease in the lymphocyte proliferation by mitogen Con-A (17.88% Table-2 ) is an indication of suppression of T-cell blastogenesis, which is essential for mounting of both the cell-mediated and humoral immune response. Earlier, workers have also reported the [ 30 ] reduced lymphocyte blastogenesis response in minks and ferrets exposed to hexachlorobenzene. Depression in cell-mediated immune response in pesticide offered birds, as observed in this study has also been reported in broilers as measured by lymphocytes migration inhibition test [ 31 ] and lymphocyte stimulation test (LST) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide dye method [ 27 , 29 , 32 ].…”

Section: Resultsmentioning

confidence: 97%

How safe is the use of chlorpyrifos: Revelations through its effect on layer birds

et al. 2016

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Aim:The present study was aimed to investigate the immunological competence of chlorpyrifos (CPF) insecticide after oral administration in layer chickens.Materials and Methods:A total of 20 White Leghorn birds were given CPF in drinking water at 0.3 ppm/bird/day (no observable effect level dose) for a period of 3-month. Immune competence status of layer birds and chicks hatched from CPF-treated birds were estimated at 15 days interval in layer birds and monthly interval in chicks using immunological and biochemical parameters.Results:There was a significant decrease in values of total leukocytes count, absolute lymphocyte count, absolute heterophil count, total serum protein, serum albumin, serum globulin, and serum gamma globulin in the birds treated with CPF as compared to control. Similarly, immune competence tests such as lymphocyte stimulation test, oxidative burst assay, and enzyme-linked immunosorbent assay tests indicated lower immunity in birds treated with CPF as compared to control. Subsequently, chicks produced from CPF-treated birds were also examined for immune competence, but no significant difference was observed between chicks of both the groups.Conclusion:The exposure to CPF produced hemo-biochemical and other changes that could be correlated with changes in the immunological profile of layer chickens suggesting total stoppage of using CPF in poultry sheds.

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“…Bush et al [ 9 ] also demonstrated that darker fur colour occurred in male kits but not female kits with supplemental copper at the 200 mg/kg level. One of the clinical signs of Cu deficiency in mink is hypochromotrichia and some mink farmers have reported feeding supplemental dietary Cu to intensify fur colour in dark mink [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary copper on organ indexes, tissular Cu, Zn and Fe deposition and fur quality of growing-furring male mink (Mustela vison)

Gao

Yang

2015

J Anim Sci Technol

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The objectives of this study were to study the effects of different levels of dietary copper on organ indexes, tissular Cu, Zn and Fe deposition and fur quality of mink in the growing-furring periods. One hundred and five standard dark male mink were randomly assigned to seven groups with the following dietary treatments: basal diet with no supplemental Cu (Control); basal diet supplemented with either 6, 12, 24, 48, 96 and 192 mg/kg Cu from copper sulphate, respectively. The colour intensity scores displayed a linear trend (P = 0.057). The spleen Cu concentrations responded in a linear (P < 0.05) fashion with increasing level of Cu, but copper supplementation did not affect speen concentrations of Fe or Zn. Supplemental dose of Cu linearly increased (P < 0.05) liver Cu and Fe concentrations but did not alter (P > 0.10) liver Zn. Our results indicate that Cu plays an important role in the pigmentation in growing-furring mink, and supplemental dietary Cu in growing-furring mink improve hair colour, and copper has limited effects on liver mineral deposition.

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Hexachlorobenzene-Induced Effects on the Lymphocyte Blastogenic Response to Concanavalin a in the Mink and European Ferret

Cited by 5 publications

References 7 publications

Effect of endosulfan on immunological competence of layer birds

Effect of endosulfan on immunological competence of layer birds

How safe is the use of chlorpyrifos: Revelations through its effect on layer birds

Effects of dietary copper on organ indexes, tissular Cu, Zn and Fe deposition and fur quality of growing-furring male mink (Mustela vison)

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