Hexadirectional coding of visual space in human entorhinal cortex

Nau, Matthias; Schröder, Tobias; Bellmund, Jacob L. S.; Doeller, Christian F.

doi:10.1038/s41593-017-0050-8

Cited by 177 publications

(232 citation statements)

References 20 publications

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“…Computational models proposed that it is the conjunction between location and direction that mediates the environmental anchoring of HD in the RSC (Bicanski and Burgess, 2016). In monkeys (Killian et al, 2015) and humans (Julian et al, 2018;Nau et al, 2018cNau et al, , 2018aStaudigl et al, 2018), eye movement direction has also been shown to modulate activity in the entorhinal cortex in which we also observed a directional code. However, these studies focused on eye movements in the 2D plane (e.g.…”

Section: Influence Of Gaze Directionsupporting

confidence: 69%

Behavior-dependent directional tuning in the human visual-navigation network

Nau

Schröder²,

Frey

et al. 2019

Preprint

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The brain derives cognitive maps from sensory experience to guide memory formation and behavior. Despite extensive efforts, it still remains unclear how the underlying population activity relates to active behavior and memory performance. Here, we combined 7T-fMRI with a kernelbased encoding model of virtual navigation to map world-centered directional tuning across the human cortex. First, we present an in-depth analysis of directional tuning in visual, retrosplenial and parahippocampal cortices and the hippocampus. Second, we show that tuning strength, width and topology of this directional code during memory-guided navigation depend on successful encoding of the environment. Finally, we show that participants' locomotory state influences this tuning in sensory and mnemonic regions such as the hippocampus. We demonstrate a direct link between neural population tuning and human cognition and show that high-level memory processing interacts with network-wide environmental coding in the service of behavior.

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Section: Influence Of Gaze Directionsupporting

confidence: 69%

Behavior-dependent directional tuning in the human visual-navigation network

Nau

Schröder²,

Frey

et al. 2019

Preprint

Self Cite

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“…Kilian et al (2012) discovered cells within the entorhinal cortex of macaques that coded the location of fixations in a grid-like fashion during a free-viewing task, serving as a potential mechanism to provide a scale-invariant representation of fixation locations within the scene (Bicanski and Burgess, 2019). Similar grid-like modulation of entorhinal activity has been observed in humans using fMRI (Julian et al, 2018;Nau et al, 2018), providing converging evidence across species that the entorhinal system may provide a spatial framework for memory-guided viewing. As such, synchronous theta oscillations between the hippocampus and entorhinal systems would provide the spatial coding necessary to inform the oculomotor system of memory-relevant information.…”

Section: Discussionmentioning

confidence: 87%

Hippocampal theta coordinates memory processing during visual exploration

Kragel¹,

VanHaerents²,

Templer³

et al. 2019

Preprint

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The hippocampus supports memory encoding and retrieval, with distinct phases of theta oscillations modulating the amplitude of gamma-band activity during each process. Encoding and retrieval operations dynamically interact over rapid timescales, especially when sensory information conflicts with memory. The ability to link hippocampal dynamics to specific memory-guided behaviors has been limited by experiments that lack the temporal resolution to segregate when encoding and retrieval occur. To resolve this issue, we simultaneously tracked eye movements and hippocampal field potentials while neurosurgical patients performed a spatial memory task. Novelty-driven fixations increased phase-locking to the theta rhythm, which predicted successful memory performance. Theta to gamma phase amplitude coupling increased during these viewing behaviors and predicted forgetting of conflicting memories. In contrast, theta phase-locking preceded fixations initiated by memory retrieval, indicating that the hippocampus coordinates memory-guided eye movements. These findings suggest that theta oscillations in the hippocampus support learning through two interleaved processes: strengthening the encoding of novel information and guiding exploration based on prior experience.

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“…110,111 Likewise, in humans, the ERC responses code for gaze direction in a grid-like fashion. 112 Neurons in the monkey PHC and hippocampus are also responsive to the spatial locations of gaze fixations, 104,[113][114][115][116][117][118] likely according to allocentric reference frames. 119 In both monkeys and humans, theta rhythm is aligned with saccades during a visual search task ( Fig.…”

Section: Neurophysiology and Oscillatory Responsesmentioning

confidence: 99%

The intersection between the oculomotor and hippocampal memory systems: empirical developments and clinical implications

Ryan

Shen

Liu

2019

Annals of the New York Academy of Sciences

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Decades of cognitive neuroscience research has shown that where we look is intimately connected to what we remember. In this article, we review findings from human and nonhuman animals, using behavioral, neuropsychological, neuroimaging, and computational modeling methods, to show that the oculomotor and hippocampal memory systems interact in a reciprocal manner, on a moment‐to‐moment basis, mediated by a vast structural and functional network. Visual exploration serves to efficiently gather information from the environment for the purpose of creating new memories, updating existing memories, and reconstructing the rich, vivid details from memory. Conversely, memory increases the efficiency of visual exploration. We call for models of oculomotor control to consider the influence of the hippocampal memory system on the cognitive control of eye movements, and for models of hippocampal and broader medial temporal lobe function to consider the influence of the oculomotor system on the development and expression of memory. We describe eye movement–based applications for the detection of neurodegeneration and delivery of therapeutic interventions for mental health disorders for which the hippocampus is implicated and memory dysfunctions are at the forefront.

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Hexadirectional coding of visual space in human entorhinal cortex

Cited by 177 publications

References 20 publications

Behavior-dependent directional tuning in the human visual-navigation network

Behavior-dependent directional tuning in the human visual-navigation network

Hippocampal theta coordinates memory processing during visual exploration

The intersection between the oculomotor and hippocampal memory systems: empirical developments and clinical implications

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