Hexaphenyltriphenylene‐Based Multicomponent Metallacages: Host–Guest Complexation for White‐Light Emission

Liu, Haifei; Guo, Chenxing; Zhang, Zeyuan; Mu, Chaoqun; Qian, Feng; Zhang, Mingming

doi:10.1002/chem.202203926

Cited by 13 publications

(5 citation statements)

References 76 publications

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“…The dimension of Cage 4b is 2.48 × 1.35 × 0.86 nm 3 . Because the distance between the neighboring pyridyl groups in 3b is much longer than that in 3a, tetracarboxylic ligand 1 is connected to the two neighboring pyridyl groups using its long side in Cage 4b, which has been also observed in our previous study [62]. The distance between the two PDI faces in Cage 4b is only 0.98 nm, much shorter than that in Cage 4a, which is better for the π-π stacking interactions between the guests and the metallacage hosts.…”

Section: Preparation and Characterization Of Metallacagessupporting

confidence: 81%

Enhancing the Photosensitivity of Hypocrellin A by Perylene Diimide Metallacage-Based Host–Guest Complexation for Photodynamic Therapy

Li,

Yang,

Peng

et al. 2024

Nano-Micro Lett.

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The development of supramolecular hosts which can efficiently encapsulate photosensitizers to improve the photodynamic efficacy holds great promise for cancer therapy. Here, we report two perylene diimide-based metallacages that can form stable host–guest complexes with planar conjugated molecules including polycyclic aromatic hydrocarbons and photosensitizers (hypocrellin A). Such host–guest complexation not only prevents the aggregation of photosensitizers in aqueous environments, but also offers fluorescence resonance energy transfer (FRET) from the metallacage to the photosensitizers to further improve the singlet oxygen generation (ΦΔ = 0.66). The complexes are further assembled with amphiphilic polymers, forming nanoparticles with improved stability for anticancer study. Both in vitro and in vivo studies indicate that the nanoparticles display excellent anticancer activities upon light irradiation, showing great potential for cancer photodynamic therapy. This study provides a straightforward and effective approach for enhancing the photosensitivity of conventional photosensitizers via host–guest complexation-based FRET, which will open a new avenue for host–guest chemistry-based supramolecular theranostics.

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Section: Preparation and Characterization Of Metallacagessupporting

confidence: 81%

Enhancing the Photosensitivity of Hypocrellin A by Perylene Diimide Metallacage-Based Host–Guest Complexation for Photodynamic Therapy

Li,

Yang,

Peng

et al. 2024

Nano-Micro Lett.

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“…Approaches pioneered by Clever, Wang, and others have leveraged a good geometric match between different ligand types. Zhang and co-workers have utilized both geometric matching between ligands and principles of charge separation to generate heteroleptic architectures from paneling ligands …”

Section: Introductionmentioning

confidence: 99%

“…Zhang and co-workers have utilized both geometric matching between ligands and principles of charge separation 6c to generate heteroleptic architectures from paneling ligands. 13 …”

Section: Introductionmentioning

confidence: 99%

Triamine and Tetramine Edge-Length Matching Drives Heteroleptic Triangular and Tetragonal Prism Assembly

Davies,

Ronson,

Nitschke

2024

J. Am. Chem. Soc.

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Heteroleptic metal−organic capsules, which incorporate more than one type of ligand, can provide enclosed, anisotropic interior cavities for binding low-symmetry molecules of biological and industrial importance. However, the selective selfassembly of a single mixed-ligand architecture, as opposed to the numerous other possible self-assembly outcomes, remains a challenge. Here, we develop a design strategy for the subcomponent self-assembly of heteroleptic metal−organic architectures with anisotropic internal void spaces. Zn 6 Tet 3 Tri 2 triangular prismatic and Zn 8 Tet 2 Tet′ 4 tetragonal prismatic architectures were prepared through careful matching of the side lengths of the tritopic (Tri) or tetratopic (Tet, Tet′) and panels.

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“…Metal-coordination-driven self-assembly has proved to be a reliable strategy for the construction of supramolecular coordination complexes (SCCs) with multifunctional geometric structures owing to the directionality and moderate bond strength of metal-coordination bonds. − Specially, metallacages, as three-dimensional SCCs, can be finely designed to encapsulate a series of guest molecules, exhibiting various applications in guest encapsulation, sensing, catalysis, stabilizing reactive intermediates, etc. − Recently, multicavity metallacages have been developed to encapsulate multiple guests cooperatively to achieve multifunctionalities. − In these systems, the multidentate ligands are designed to be sufficiently rigid to avoid the formation of thermodynamic byproducts, so most of the multicavity metallacages only show binding affinity similar to the sum of their individual metallacage precursors. The construction of multicavity metallacages with certain flexibility to allow intramolecular communication between different guest molecules for allosteric recognition has been rarely reported.…”

Section: Introductionmentioning

confidence: 99%

Multicomponent, Multicavity Metallacages That Contain Different Binding Sites for Allosteric Recognition

Liu,

Guo,

et al. 2024

J. Am. Chem. Soc.

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The encapsulation of different guest molecules by their different recognition domains of proteins leads to selective binding, catalysis, and transportation. Synthetic hosts capable of selectively binding different guests in their different cavities to mimic the function of proteins are highly desirable but challenging. Here, we report three ladder-shaped, triple-cavity metallacages prepared by multicomponent coordination-driven self-assembly. Interestingly, the porphyrin-based metallacage is capable of heteroleptic encapsulation of fullerenes (C60 or C70) and coronene using its different cavities, allowing distinct allosteric recognition of coronene upon the addition of C60 or C70. Owing to the different binding affinities of the cavities, the metallacage hosts one C60 molecule in the central cavity and two coronene units in the side cavities, while encapsulating two C70 molecules in the side cavities and one coronene molecule in the central cavity. The rational design of multicavity assemblies that enable heteroleptic encapsulation and allosteric recognition will guide the further design of advanced supramolecular constructs with tunable recognition properties.

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Hexaphenyltriphenylene‐Based Multicomponent Metallacages: Host–Guest Complexation for White‐Light Emission

Cited by 13 publications

References 76 publications

Enhancing the Photosensitivity of Hypocrellin A by Perylene Diimide Metallacage-Based Host–Guest Complexation for Photodynamic Therapy

Enhancing the Photosensitivity of Hypocrellin A by Perylene Diimide Metallacage-Based Host–Guest Complexation for Photodynamic Therapy

Triamine and Tetramine Edge-Length Matching Drives Heteroleptic Triangular and Tetragonal Prism Assembly

Multicomponent, Multicavity Metallacages That Contain Different Binding Sites for Allosteric Recognition

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