Hexosamine and Acid-hydrolyzable Sulfate Concentrations of the Aorta and Pulmonary Artery in Individuals of Various Ages

Kirk, J. E.; Dyrbye, Martin

doi:10.1093/geronj/11.3.273

Cited by 48 publications

(7 citation statements)

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“…This agrees with the data of Bertelsen [1], but not with those of Kirk and Dyrbye [11], who reported that there were no differences in the GAG con tents determined as hexosamines between the aorta and pulmonary arteries. The present data are the first to show that a higher proportion of HA is present in the pulmonary arteries compared to the aorta.…”

Section: Discussionsupporting

confidence: 89%

High Hyaluronic Acid and Low Dermatan Sulfate Contents in Human Pulmonary Arteries Compared to in the Aorta

Murata

Yokoyama²

1988

J Vasc Res

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We examined the glycosaminoglycan (GAG) components in human pulmonary arteries compared to those in the aorta. Definite changes in GAG contents and components were found between the pulmonary arteries and the aorta. The GAG content of the aorta was constantly higher than that of the pulmonary artery. As to the components of the arterial GAGs, however, hyaluronic acid comprised significantly higher proportions of total GAGs in the pulmonary arteries than in the aorta, whereas dermatan sulfate showed lower proportions in the pulmonary arteries than in the aorta. These significant differences are possibly due to either the effect of the continuously different blood pressure on the wall of these two types of arterial vessels or to constitutional changes of their fundamental structures associated with atherosclerosis.

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Section: Discussionsupporting

confidence: 89%

High Hyaluronic Acid and Low Dermatan Sulfate Contents in Human Pulmonary Arteries Compared to in the Aorta

Murata

Yokoyama²

1988

J Vasc Res

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“…Water content is highest at ages 40 to 49. That of the cerebral arteries was somewhat higher than in the coronary arteries 31 46 -47 and aorta, 48 but lower than in the heart valves. 49 Our determination of water content in the cerebral arteries agreed with data from other authors.…”

Section: Discussionmentioning

confidence: 71%

Distribution of acidic glycosaminoglycans, lipids and water in normal human cerebral arteries at various ages.

Murata¹

1985

Stroke

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SUMMARY Functional alterations in arterial acidic glycosaminoglycans (AGAG) may be related to the pathogenesis of some forms of cerebrovascular disease. We measured the AGAG, lipid and water content of human cerebral artery of 275 normal males at various ages. These measures were separately carried out in the main trunk and distal branches. The AGAG components were analyzed by an enzymatic assay method employing specific enzymes which digest AGAG to assess topographic change and aging variations. The total AGAG content was higher in the main cerebral artery than in the distal branches. The main AGAG component of the normal main cerebral artery was heparan sulfates (HS), constituting half the total AGAG, followed by moderate amounts of dermatan sulfate (DS), chondroitin-6-sulfate (C-6S) and chondroitin-4-sulfate (C-4S). Hyaluronic acid (HA) was a minor component and it was more prominent in young arteries. Heparin could be occasionally detected. With advancing age, the relative amounts of HS, HA, chondroitin and C-4S both in the main trunk and distal branches decreased but those of DS and C-6S increased. The total lipid, cholesterol ester and triglyceride content was greater in the main trunk than in the distal branches; the total lipid content increased with age. A possible function of the cerebral arterial AGAG is discussed with respect to change in lipid and water content according to topographic sites and aging.

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“…They furthermore suggested that a binding of hexosamine with scleroprolein is the earlier biochem ical alteration in the intima of atherosclerotic aortae. Kirk and Dyrbye (13) reported a decrease of hexosamine values in the inInna and media of severely atherosclerotic aortae when compared with samples classified as having " none, slight, and moderate" atherosclerosis. Buddecke reported a marked increase of hexosam ines in human (6) as well as in spontaneous atherosclerosis of chickens (7).…”

Section: Discussionmentioning

confidence: 99%

Hexosamine Concentration in Aorta, Liver, Kidney and Adrenal of Cholesterol-Fed Rabbits

Paronetto¹

1962

Pathobiology

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Hexosamine and Acid-hydrolyzable Sulfate Concentrations of the Aorta and Pulmonary Artery in Individuals of Various Ages

Cited by 48 publications

References 0 publications

High Hyaluronic Acid and Low Dermatan Sulfate Contents in Human Pulmonary Arteries Compared to in the Aorta

High Hyaluronic Acid and Low Dermatan Sulfate Contents in Human Pulmonary Arteries Compared to in the Aorta

Distribution of acidic glycosaminoglycans, lipids and water in normal human cerebral arteries at various ages.

Hexosamine Concentration in Aorta, Liver, Kidney and Adrenal of Cholesterol-Fed Rabbits

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