Hexosamine and Hydroxyproline Concentrations in Skin and Buccal Mucosa of an Aging Rat Population

Murray, David H.; Watts, W. R.; Ring, John R.

doi:10.1093/geronj/16.1.17

Cited by 14 publications

(3 citation statements)

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“…However, there is a drastic increase in the amount of insoluble collagen. Similar results have been reported in skin and buccal mucosa of aging rats by Murray et al [1961]. Sobel et al [1958] reported that the decrease in collagen content was not so large as that of hexosamine, thus resulting in a decrease in the ratio of hexosamine to collagen content in the skin and aorta with increasing age.…”

Section: Discussionsupporting

confidence: 86%

“…Similar changes were found in acidsoluble collagen (Figure 4b). In contrast, the concentration of insoluble collagen increased markedly with age as observed with other connective tissue [Murray et al, 1961]. As shown in Figure 5, therefore, the ratio of GAGs to collagen content decreased with the growth of the animals.…”

Section: Quantitative and Qualitative Analysis Of Gagssupporting

confidence: 51%

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Age‐Related Changes in Collagen and Glycosaminoglycans of Rat Gingiva¹

Shikata

1984

Gerodontology

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Age‐related changes in collagen and glycosaminoglycans (GAGs) of rat gingiva were studied biochemically and histologically. The components of isolated GAGs were identified as dermatan sulphate, hyaluronic acid, and heparan sulphate. In histological studies, hyaluronic acid was present in all regions of the gingiva, whereas dermatan sulphate and heparan sulphate were present only in gingival connective tissue. However, there was no significant difference in the relationship between aging, and the content or distribution of GAGs. On the other hand, histological findings showed that collagen fibers were markedly increased in number and the vascular composition was decreased with increasing age. In biochemical studies, the content of collagen, especially of insoluble collagen, was greatly increased with age, whereas collagen biosynthesis and collagenolytic activity were markedly decreased. In addition, lysyl oxidase activity was also significantly decreased with age. The results indicate that the rate of collagen turnover decreases and collagen fibers increase in stability in rat gingiva with increasing age. These observed age‐related changes may affect the ability of gingiva to respond to local irritants.

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Section: Discussionsupporting

confidence: 86%

Section: Quantitative and Qualitative Analysis Of Gagssupporting

confidence: 51%

Age‐Related Changes in Collagen and Glycosaminoglycans of Rat Gingiva¹

Shikata

1984

Gerodontology

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“…6 '7 Cytochemical studies on the buccal mucosa of aging rats revealed a nonsignificant hexosamine concentration with increasing age; whereas, a significant hydroxyproline concentration was noted during the rats' growth but remained unchanged during adulthood and senescense. 8 Observations of chemical changes in the palate of the guinea pig showed no significant differences between sexes of the same age groups in noncollagenous to collagenous ratio components.9 Recent studies on palatal tissue obtained from guinea pigs showed significant changes with age in the protein-bound hexoses and collagenous protein-bound hexoses.10 Human oral mucosal changes associated with aging have been reported to show a reduction of both mucoprotein and protein-bound carbohydrates. "2 The present investigation concerned whether certain biochemical differences existed in the soft tissues of the hard palate and buccal gingival tissues of the same guinea pigs of known age.…”

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confidence: 99%