NINE FIGURESThe production of swcating by appropriate nervous stimulation was first demoiistrated by Goltz in 1875. We have been unable to find in the literature any detailed description of the histological response of the sweat glands to such stimulation, although Way and Memmesheimer ( '36) have briefly described changes in the sweat cells in normal human material fixed in the "secretory" and "exhausted" state.It was deemed advisable as a preliminary to a projected experimental study of sudomotor function to undertake an investigation of changes in the sweat glands in response to electrical stimulation of sudomotor nerves. The albino rat was the animal of choice for reasons of convenience and economy. However a search of the literature failed to reveal any significant discussion of the normal histolo,gy of sweat glands in this species, and a t least 1 author maintained that the rat was devoicl of sweat ?lands.The present report therefore presents the normal histology and distribution of sweat glands in the albino rat together with a description of the changes accompanying prolonged, continuous stimulation of these glands.l Present address : Washington University School of Dentistry, St. Louis 10, Mn.

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Increase in alkaline phosphatase activity of vaginal epithelium of the mouse following administration of estrogen to spayed animals has been reported by Jeener ('47) and Kame11 and Atkinson ( '48). The present study represents an attempt to correlate the changes in localization and intensity of phosphatase activity in vaginal epithelium with the structural changes occurring during the growth and regression of this membrane seen in the several stages of the estrous cycle of the normal rat. MATERIAL AND METHODSA large group of albino female rats was examined by daily vaginal smears through 3 or 4 estrous cycles. The smears were obtained by lavage in order to minimize trauma to the vagina. Eighteen animals which had exhibited normal cycles were sacrificed, 5 each in diestrus, proestrus, and estrus and three in metestrus.Five female rats spayed for periods of from 2 to 5 weeks were injected with estradiol benzoate in oil. The total amounts administered over three days ranged from 0.15 to 0.5mg.Five uninjected spayed females served as controls. The spayed animals were killed on the day following the last injection.121

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